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IL2RB [plasma membrane]
Stable Identifier
R-HSA-197876
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-2 receptor beta chain, IL2B_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
IL2RB binds JAK1 (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
SYK is a substrate for JAK1 (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14784 IL2RB
Gene Names
IL2RB, IL15RB
Chain
signal peptide:1-26, chain:27-551
Reference Genes
BioGPS Gene:3560 IL2RB
COSMIC (genes):IL2RB IL2RB
CTD Gene:3560 IL2RB
dbSNP Gene:3560 IL2RB
ENSEMBL:ENSG00000100385.14 IL2RB
HGNC:6009 IL2RB
KEGG Gene (Homo sapiens):3560 IL2RB
Monarch:3560 IL2RB
NCBI Gene:3560 IL2RB
OMIM:146710 IL2RB
UCSC:P14784 IL2RB
Reference Transcript
RefSeq:NM_001346223.1 IL2RB
RefSeq:NM_001346222.1 IL2RB
RefSeq:NM_000878.4 IL2RB
Other Identifiers
0005390193
11722635_at
1365_at
16934709
205291_PM_at
205291_at
3560
3959988
3959989
3959990
3959991
3959992
3959993
3959994
3959995
3959997
3959998
3959999
3960000
3960001
3960002
3960003
7896691
7896708
8075886
A_24_P203000
GE62412
GO:0002376
GO:0004896
GO:0004911
GO:0005515
GO:0005622
GO:0005737
GO:0005768
GO:0005829
GO:0005886
GO:0005887
GO:0005893
GO:0007165
GO:0009897
GO:0009986
GO:0012501
GO:0016020
GO:0016021
GO:0016192
GO:0019221
GO:0019976
GO:0023052
GO:0030101
GO:0031410
GO:0032991
GO:0035723
GO:0038110
GO:0042010
GO:0043066
GO:0043226
GO:0050766
GO:0060089
GO:0065003
HMNXSV003043276
ILMN_1684349
M26062_at
PH_hs_0004344
TC22000722.hg
g4504664_3p_at
Participates
as a component of
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2RB:p-JAK1 [plasma membrane] (Homo sapiens)
as an input of
IL2RB binds JAK1 (Homo sapiens)
Other forms of this molecule
IL2RB [endosome]
p-Y-IL2RB [cytosol]
p-Y364,Y418,Y536-IL2RB [plasma membrane]
Inferred To
il-2rb [plasma membrane]
(Danio rerio)
Homologues of IL2RB [plasma membrane]
(Danio rerio)
il2rb [plasma membrane]
(Xenopus tropicalis)
IL2RB [plasma membrane]
(Bos taurus)
IL2RB [plasma membrane]
(Canis familiaris)
IL2RB [plasma membrane]
(Danio rerio)
IL2RB [plasma membrane]
(Gallus gallus)
IL2RB [plasma membrane]
(Sus scrofa)
Il2rb [plasma membrane]
(Mus musculus)
Il2rb [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001333152.1
,
NP_001333151.1
,
NP_000869.1
Guide to Pharmacology - Targets
1696
OpenTargets
ENSG00000100385
HPA
ENSG00000100385-IL2RB
GeneCards
P14784
Ensembl
ENST00000216223
,
ENSP00000216223
,
ENSG00000100385
PRO
P14784
Pharos - Targets
P14784
Orphanet
22169
PDB
5M5E
,
4GS7
,
7S2S
,
6E8K
,
2ERJ
,
3QAZ
,
2B5I
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60568 IL2
1
IL2 [extracellular region]
(R-HSA-447099)
0.737
5
UniProt:P40933 IL15
2
IL15 [endosome]
(R-HSA-8983123)
IL15 [extracellular region]
(R-HSA-447242)
0.658
3
UniProt:Q13261 IL15RA
2
IL15RA [endosome]
(R-HSA-8983117)
IL15RA [plasma membrane]
(R-HSA-449122)
0.591
3
UniProt:Q15645 PCH2
0.556
3
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