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IL15RA [plasma membrane]
Stable Identifier
R-HSA-449122
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Interleukin-15 receptor subunit alpha, I15RA_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL15RA (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15RA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13261 IL15RA
Gene Names
IL15RA
Chain
signal peptide:1-30, chain:31-267, chain:31-
Reference Genes
BioGPS Gene:3601 IL15RA
COSMIC (genes):IL15RA IL15RA
CTD Gene:3601 IL15RA
dbSNP Gene:3601 IL15RA
ENSEMBL:ENSG00000134470 IL15RA
HGNC:5978 IL15RA
KEGG:hsa:3601 IL15RA
Monarch:3601 IL15RA
NCBI Gene:3601 IL15RA
OMIM:601070 IL15RA
UCSC:Q13261 IL15RA
Reference Transcript
RefSeq:NM_172200.2 IL15RA
RefSeq:NM_001243539.1 IL15RA
RefSeq:NM_002189.3 IL15RA
RefSeq:NM_001256765.1 IL15RA
Other Identifiers
11731039_s_at
11732019_a_at
11748229_x_at
16711484
207375_PM_s_at
207375_s_at
3275679
3275681
3275691
3275693
3275694
3275695
3275696
3275697
3275698
3275699
3275700
3275701
3275702
3275703
3275704
3275706
3275707
3275710
3275711
3275712
3275716
3275717
3275718
3275719
3601
41677_at
495_at
7931899
88582_at
A_33_P3399263
A_33_P3399267
A_33_P3399268
GE59079
GE863325
GO:0000139
GO:0001779
GO:0002376
GO:0004896
GO:0005515
GO:0005576
GO:0005634
GO:0005768
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0007259
GO:0009986
GO:0010977
GO:0016020
GO:0019901
GO:0030154
GO:0030659
GO:0031410
GO:0031667
GO:0031965
GO:0032825
GO:0035723
GO:0042010
GO:0043226
GO:0050766
GO:0060089
HMNXSV003040801
HMNXSV003041143
ILMN_1665682
ILMN_1693910
ILMN_1759958
PH_hs_0001190
TC10001006.hg
TC10002441.hg
U31628_at
g4504648_3p_a_at
p28996
Participates
as an input of
IL15 binds IL15RA (Homo sapiens)
as a component of
IL15:IL15RA [plasma membrane] (Homo sapiens)
Other forms of this molecule
IL15RA [endosome]
Inferred To
Ghost homologue of IL15RA [plasma membrane]
(Gallus gallus)
Ghost homologue of IL15RA [plasma membrane]
(Sus scrofa)
IL15RA [plasma membrane]
(Bos taurus)
IL15RA [plasma membrane]
(Canis familiaris)
Il15ra [plasma membrane]
(Mus musculus)
Il15ra [plasma membrane]
(Rattus norvegicus)
il15ra [plasma membrane]
(Danio rerio)
Cross References
Guide to Pharmacology - Targets
1702
ENSEMBL
ENST00000528354
,
ENST00000530685
,
ENSP00000369306
,
ENSP00000369312
,
ENSP00000431529
,
ENST00000379971
,
ENST00000397250
,
ENST00000397255
,
ENSP00000435995
,
ENST00000525219
,
ENSP00000380422
,
ENSP00000380426
,
ENSG00000134470
,
ENST00000379977
,
ENSP00000435454
OpenTargets
ENSG00000134470
GeneCards
IL15RA
HPA
ENSG00000134470-IL15RA
PRO
Q13261
Pharos - Targets
Q13261
GlyGen
Q13261
PDB
2Z3R
,
2ERS
,
2Z3Q
,
4GS7
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40933 IL15
2
IL15 [endosome]
(R-HSA-8983123)
IL15 [extracellular region]
(R-HSA-447242)
0.656
5
UniProt:P14784 IL2RB
4
p-Y364,Y418,Y536-IL2RB [plasma membrane]
(R-HSA-452093)
IL2RB [plasma membrane]
(R-HSA-197876)
p-Y-IL2RB [cytosol]
(R-HSA-9009733)
IL2RB [endosome]
(R-HSA-8983172)
0.591
3
UniProt:P31785 IL2RG
4
IL2RG [plasma membrane]
(R-HSA-449139)
p-Y-IL2RG [plasma membrane]
(R-HSA-6786103)
p-Y-IL2RG [cytosol]
(R-HSA-9009721)
IL2RG [endosome]
(R-HSA-8983165)
0.524
2
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