Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
IL2 [extracellular region]
Stable Identifier
R-HSA-447099
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-2, IL2_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) (Homo sapiens)
IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin-2 receptor alpha:IL2 binds Interleukin-2 receptor beta (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin-2: IL2 receptor alpha:beta binds IL2 receptor gamma subunit (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated STAT5 is released (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylation of IL2RB Y338 enables SHC recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylation of IL2RB Y338, Y392 or Y510 enables STAT recruitment (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Recruited STAT5 is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3:STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer p-(Y338,Y392, Y510) beta subunit:p-JAK1:JAK3:p-STAT5 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
SHC1 bound to IL2 receptor is phosphorylated (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
SYK is a substrate for JAK1 (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:p-SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Within the IL-2R complex JAK3 phosphorylates JAK1 (Homo sapiens)
IL2:IL2R trimer:JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2RA:IL2RB:JAK1 [plasma membrane] (Homo sapiens)
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
Gab2 binds the p85 subunit of Class 1A PI3 kinases (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2:p85-containing Class 1 PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338) beta subunit:p-SHC:GRB2:GAB2:p85-containing Class 1A PI3Ks [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC recruits GRB2:SOS1 (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC1 recruits GRB2:GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Phosphorylated SHC1 recruits SHIP (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1,2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
SHC1 mediates cytokine-induced phosphorylation of GAB2 (Homo sapiens)
Interleukin receptor compexes with activated Shc:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated Shc:GRB2:p-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p(Y338,392,510) beta subunit:p-SHC:GRB2:p(Y)-GAB2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:GRB2:SOS1 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510)-beta subunit:p-JAK1:JAK3:p-SHC [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P60568 IL2
Gene Names
IL2
Chain
signal peptide:1-20, chain:21-153
Reference Genes
BioGPS Gene:3558 IL2
COSMIC (genes):IL2 IL2
CTD Gene:3558 IL2
dbSNP Gene:3558 IL2
ENSEMBL:ENSG00000109471 IL2
ENSEMBL:ENSG00000109471.5 IL2
HGNC:6001 IL2
KEGG Gene (Homo sapiens):3558 IL2
Monarch:3558 IL2
NCBI Gene:3558 IL2
OMIM:147680 IL2
Reference Transcript
RefSeq:NM_000586.3 IL2
Other Identifiers
11733943_at
1538_s_at
16979570
207849_PM_at
207849_at
2784266
2784267
2784268
2784269
2784270
2784272
2784273
34021_at
3558
8102697
A_23_P30115
A_23_P30122
GE902998
GO:0001933
GO:0001934
GO:0002250
GO:0002366
GO:0002376
GO:0002639
GO:0002903
GO:0005125
GO:0005134
GO:0005515
GO:0005576
GO:0005615
GO:0006310
GO:0006351
GO:0006355
GO:0006366
GO:0006954
GO:0006955
GO:0007155
GO:0007186
GO:0007204
GO:0007205
GO:0007260
GO:0007267
GO:0008083
GO:0008284
GO:0008289
GO:0010467
GO:0012501
GO:0019209
GO:0023052
GO:0030101
GO:0030154
GO:0030217
GO:0030246
GO:0030307
GO:0030890
GO:0031851
GO:0032729
GO:0032740
GO:0034105
GO:0036211
GO:0038110
GO:0042098
GO:0042102
GO:0042104
GO:0042531
GO:0043066
GO:0043208
GO:0045471
GO:0045582
GO:0045591
GO:0045944
GO:0046013
GO:0046651
GO:0048018
GO:0048304
GO:0048856
GO:0050672
GO:0050728
GO:0050729
GO:0050798
GO:0060999
GO:0097192
GO:0098772
GO:1900100
GO:2000320
GO:2000561
HMNXSV003025138
ILMN_1704321
PH_hs_0005013
S77835_s_at
TC04001520.hg
TC04002704.hg
X00695_s_at
g10835148_3p_at
Participates
as an output of
IL2 gene expression is stimulated by RUNX1 and NFATC2 and repressed by FOXP3 (Homo sapiens)
as an input of
Interleukin-2 receptor alpha binds interleukin-2 (Homo sapiens)
as a component of
IL2:IL2RA [plasma membrane] (Homo sapiens)
IL2RA:IL2RB:p-JAK1:IL2 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
IL2:IL2R trimer p-(Y338,392,510) beta subunit:p-JAK1:JAK3 [plasma membrane] (Homo sapiens)
Inferred To
Ghost homologue of IL2 [extracellular region]
(Bos taurus)
Ghost homologue of IL2 [extracellular region]
(Canis familiaris)
Ghost homologue of IL2 [extracellular region]
(Danio rerio)
Ghost homologue of IL2 [extracellular region]
(Gallus gallus)
Ghost homologue of IL2 [extracellular region]
(Mus musculus)
Ghost homologue of IL2 [extracellular region]
(Rattus norvegicus)
Ghost homologue of IL2 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_000577.2
ZINC - World Drugs
IL2_HUMAN
OpenTargets
ENSG00000109471
ZINC - Substances
IL2_HUMAN
ZINC target
P60568
ZINC - Biogenic
IL2_HUMAN
PRO
P60568
PDB
7RA9
,
1M48
,
1M47
,
5UTZ
,
6YE3
,
3QAZ
,
7DR4
,
6LX3
,
3QB1
,
7M2G
,
2B5I
,
1M49
,
5LQB
,
3INK
,
1M4B
,
5M5E
,
6LXW
,
4NEJ
,
1Z92
,
4NEM
,
7ZMZ
,
2ERJ
,
1M4A
,
7RAA
,
6VWU
,
1QVN
,
1NBP
,
1IRL
,
1PY2
,
1PW6
,
1M4C
ZINC - Metabolites
IL2_HUMAN
GeneCards
P60568
HPA
ENSG00000109471-IL2
Ensembl
ENSG00000109471
,
ENSP00000226730
,
ENST00000226730
Pharos - Targets
P60568
ZINC - Predictions - Purchasable
IL2_HUMAN
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14784 IL2RB
4
IL2RB [endosome]
(R-HSA-8983172)
p-Y-IL2RB [cytosol]
(R-HSA-9009733)
IL2RB [plasma membrane]
(R-HSA-197876)
p-Y364,Y418,Y536-IL2RB [plasma membrane]
(R-HSA-452093)
0.737
5
UniProt:P31785-1 IL2RG
0.667
3
UniProt:P01589 IL2RA
1
IL2RA [plasma membrane]
(R-HSA-450046)
0.667
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text