Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y-IL2RB [cytosol]
Stable Identifier
R-HSA-9009733
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
p-Y-IL2RB [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14784 IL2RB
Gene Names
IL2RB, IL15RB
Chain
signal peptide:1-26, chain:27-551
Reference Genes
BioGPS Gene:3560 IL2RB
COSMIC (genes):IL2RB IL2RB
CTD Gene:3560 IL2RB
dbSNP Gene:3560 IL2RB
ENSEMBL:ENSG00000100385 IL2RB
HGNC:6009 IL2RB
KEGG:hsa:3560 IL2RB
Monarch:3560 IL2RB
NCBI Gene:3560 IL2RB
OMIM:146710 IL2RB
UCSC:P14784 IL2RB
Reference Transcript
RefSeq:NM_000878.4 IL2RB
RefSeq:NM_001346222.1 IL2RB
RefSeq:NM_001346223.1 IL2RB
Other Identifiers
11722635_at
1365_at
16934709
205291_PM_at
205291_at
3560
3959988
3959989
3959990
3959991
3959992
3959993
3959994
3959995
3959996
3959997
3959998
3959999
3960000
3960001
3960002
3960003
7896691
7896708
8075886
A_24_P203000
GE62412
GO:0002376
GO:0004896
GO:0004911
GO:0005515
GO:0005768
GO:0005829
GO:0005886
GO:0005893
GO:0007165
GO:0007166
GO:0009897
GO:0009986
GO:0015026
GO:0016020
GO:0016064
GO:0019221
GO:0019976
GO:0031410
GO:0035723
GO:0038110
GO:0042010
GO:0043066
GO:0043226
GO:0050766
GO:0060089
GO:0065003
HMNXSV003043276
ILMN_1684349
M26062_at
PH_hs_0004344
TC22000722.hg
g4504664_3p_at
Participates
as a component of
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y364,Y418,Y536-IL2RB [plasma membrane]
IL2RB [plasma membrane]
IL2RB [endosome]
Inferred To
phospho-Il2rb [cytosol]
(Mus musculus)
phospho-Il2rb [cytosol]
(Rattus norvegicus)
phospho-IL2RB [cytosol]
(Canis familiaris)
phospho-IL2RB [cytosol]
(Gallus gallus)
phospho-IL2RB [cytosol]
(Sus scrofa)
phospho-p-Y-IL2RB [cytosol]
(Bos taurus)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_000869.1
,
NP_001333151.1
,
NP_001333152.1
Guide to Pharmacology - Targets
1696
OpenTargets
ENSG00000100385
ENSEMBL
ENSP00000216223
,
ENST00000445595
,
ENSP00000514005
,
ENSP00000401020
,
ENSP00000403731
,
ENST00000698883
,
ENST00000698890
,
ENST00000698892
,
ENSP00000402685
,
ENSP00000514011
,
ENSP00000514012
,
ENST00000216223
,
ENST00000453962
,
ENST00000429622
,
ENST00000698893
,
ENSP00000514009
HPA
ENSG00000100385-IL2RB
PRO
P14784
Pharos - Targets
P14784
Orphanet
IL2RB
GlyGen
P14784
PDB
3QAZ
,
4GS7
,
7S2S
,
2ERJ
,
2B5I
,
5M5E
,
6E8K
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P60568 IL2
1
IL2 [extracellular region]
(R-HSA-447099)
0.737
5
UniProt:P40933 IL15
2
IL15 [endosome]
(R-HSA-8983123)
IL15 [extracellular region]
(R-HSA-447242)
0.658
3
UniProt:Q13261 IL15RA
2
IL15RA [endosome]
(R-HSA-8983117)
IL15RA [plasma membrane]
(R-HSA-449122)
0.591
3
UniProt:Q15645 PCH2
0.556
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text