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IL15 [extracellular region]
Stable Identifier
R-HSA-447242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-15, IL15_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL15RA (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40933 IL15
Gene Names
IL15
Chain
signal peptide:1-29, propeptide:30-48, chain:49-162
Reference Genes
BioGPS Gene:3600 IL15
COSMIC (genes):IL15 IL15
CTD Gene:3600 IL15
dbSNP Gene:3600 IL15
ENSEMBL:ENSG00000164136 IL15
HGNC:5977 IL15
KEGG Gene (Homo sapiens):3600 IL15
Monarch:3600 IL15
NCBI Gene:3600 IL15
OMIM:600554 IL15
UCSC:P40933 IL15
Reference Transcript
RefSeq:NM_000585.4 IL15
RefSeq:NM_172175.2 IL15
Other Identifiers
0002370463
0002450541
0003140138
0104810463
1036_at
11725255_a_at
11740881_x_at
11759832_a_at
16970971
205992_s_at
217371_s_at
2745290
2745291
2745292
2745293
2745294
2745296
2745301
2745302
2745307
2745308
2745309
2745310
2745311
2745312
2745313
2745314
2745315
2745316
2745317
2745320
2745322
2745323
2745324
2745325
2745326
2XQB
2Z3Q
2Z3R
3600
37738
38488_s_at
4457
4GS7
66883_r_at
8097553
A_14_P113197
AAA21551
AAB97518
AAH18149
AAI00962
AAI00963
AAI00964
AAU21241
AF031167
AK122993
AK290619
AY720442
BAF83308
BAG53839
BC018149
BC100961
BC100962
BC100963
CAA62616
CAA63913
CAA63914
CAA71044
CAA86100
CAB004457
CAG46777
CAG46804
CCDS3755
CCDS3756
CH471056
CR541980
CR542007
EAX05083
EAX05084
EAX05085
EAX05086
EAX05087
ENSG00000164136
ENSP00000296545
ENSP00000323505
ENSP00000377714
ENSP00000422271
ENSP00000435462
ENSP00000436914
ENST00000296545
ENST00000296545.11
ENST00000320650
ENST00000394159
ENST00000394159.2
ENST00000477265
ENST00000477265.5
ENST00000514653
ENST00000514653.5
ENST00000529613
ENST00000529613.5
EntrezGene:3600
EntrezGene:IL15
g10835152_3p_x_at
GE79677
GO:0001866
GO:0002376
GO:0003674
GO:0005125
GO:0005126
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0006464
GO:0006810
GO:0006950
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007260
GO:0007267
GO:0007568
GO:0008150
GO:0008283
GO:0008284
GO:0009058
GO:0009986
GO:0014732
GO:0016192
GO:0016607
GO:0021700
GO:0030154
GO:0030212
GO:0030225
GO:0031410
GO:0031667
GO:0032740
GO:0032819
GO:0032825
GO:0034105
GO:0035723
GO:0042102
GO:0042119
GO:0042531
GO:0042592
GO:0043226
GO:0044281
GO:0045062
GO:0045580
GO:0048469
GO:0048535
GO:0048662
GO:0048856
GO:0050691
GO:0050729
GO:0050731
GO:0050766
GO:0050778
GO:0071305
GO:0120163
GO:1904100
HGNC:5977
HPA037738
Hs.168132.2.S1_3p_a_at
IL15
IL15-201
IL15-202
IL15-203
IL15-204
IL15-207
IL15-208
ILMN_1724181
ILMN_1785312
ILMN_2273053
ILMN_2369221
IPR003443
IPR009079
IPR020439
IPR020466
IPR038327
MIM:600554
NM_000585
NM_172175
NP_000576
NP_751915
NR_037840
PF02372
PH_hs_0010067
PR01930
PR01947
TC04000693.hg
TC04002235.hg
U14407
U14407_at
UPI000002ABCC
UPI0000031AC7
X91233
X94222
X94223
Y09908
Z38000
Participant Of
hasComponent
IL15:IL15RA [plasma membrane]
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane]
input
IL15 binds IL15RA
IL15 binds IL2RB:JAK1 and IL2RG:JAK3
Other forms of this molecule
IL15 [endosome]
Inferred To
Il15 [extracellular region] (Mus musculus)
Il15 [extracellular region] (Rattus norvegicus)
il15l [extracellular region] (Danio rerio)
Homologues of IL15 [extracellular region] (Danio rerio)
loc100145496 [extracellular region] (Xenopus tropicalis)
IL15 [extracellular region] (Bos taurus)
IL15 [extracellular region] (Canis familiaris)
IL15 [extracellular region] (Danio rerio)
IL15 [extracellular region] (Gallus gallus)
IL15 [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_000576.1
,
NP_751915.1
OpenTargets
ENSG00000164136
HPA
ENSG00000164136-IL15
GeneCards
P40933
Ensembl
ENSP00000296545
,
ENST00000296545
,
ENSP00000377714
,
ENST00000320650
,
ENSP00000422271
,
ENST00000394159
,
ENST00000514653
,
ENSP00000436914
,
ENST00000477265
,
ENSP00000323505
,
ENST00000529613
,
ENSG00000164136
,
ENSP00000435462
PRO
P40933
Orphanet
28518
PDB
2Z3Q
,
2XQB
,
2Z3R
,
4GS7
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14784 IL2RB
4
p-Y-IL2RB [cytosol]
(R-HSA-9009733)
IL2RB [endosome]
(R-HSA-8983172)
IL2RB [plasma membrane]
(R-HSA-197876)
p-Y364,Y418,Y536-IL2RB [plasma membrane]
(R-HSA-452093)
0.658
3
UniProt:Q13261 IL15RA
2
IL15RA [endosome]
(R-HSA-8983117)
IL15RA [plasma membrane]
(R-HSA-449122)
0.656
5
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