Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
IL15 [extracellular region]
Stable Identifier
R-HSA-447242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-15, IL15_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL15RA (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40933 IL15
Gene Names
IL15
Chain
signal peptide:1-29, propeptide:30-48, chain:49-162
Reference Genes
BioGPS Gene:3600 IL15
COSMIC (genes):IL15 IL15
CTD Gene:3600 IL15
dbSNP Gene:3600 IL15
ENSEMBL:ENSG00000164136 IL15
HGNC:5977 IL15
KEGG:hsa:3600 IL15
Monarch:3600 IL15
NCBI Gene:3600 IL15
OMIM:600554 IL15
UCSC:P40933 IL15
Reference Transcript
RefSeq:NM_000585.4 IL15
RefSeq:NM_172175.2 IL15
Other Identifiers
1036_at
11725255_a_at
11740881_x_at
11759832_a_at
16970971
205992_PM_s_at
205992_s_at
217371_PM_s_at
217371_s_at
2745290
2745291
2745292
2745293
2745294
2745296
2745301
2745302
2745307
2745308
2745309
2745310
2745311
2745312
2745313
2745314
2745315
2745316
2745317
2745318
2745319
2745320
2745322
2745323
2745324
2745325
2745326
3600
38488_s_at
66883_r_at
8097553
A_14_P113197
GE79677
GO:0001779
GO:0001787
GO:0001819
GO:0001866
GO:0002376
GO:0005125
GO:0005126
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0006955
GO:0007165
GO:0007260
GO:0007267
GO:0008284
GO:0016607
GO:0023052
GO:0030154
GO:0030225
GO:0031410
GO:0032740
GO:0032819
GO:0032825
GO:0034105
GO:0035723
GO:0042102
GO:0042119
GO:0043226
GO:0045062
GO:0045580
GO:0048018
GO:0048469
GO:0048535
GO:0048856
GO:0050691
GO:0050729
GO:0050731
GO:0050766
GO:0050778
GO:0098772
GO:0120163
GO:1904100
HMNXSV003050130
Hs.168132.2.S1_3p_a_at
ILMN_1724181
ILMN_1785312
ILMN_2273053
ILMN_2369221
PH_hs_0010067
TC04000693.hg
TC04002235.hg
U14407_at
g10835152_3p_x_at
Participates
as a component of
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
as an input of
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15 binds IL15RA (Homo sapiens)
Other forms of this molecule
IL15 [endosome]
Inferred To
Il15 [extracellular region]
(Mus musculus)
Il15 [extracellular region]
(Rattus norvegicus)
il15 [extracellular region]
(Danio rerio)
IL15 [extracellular region]
(Bos taurus)
IL15 [extracellular region]
(Canis familiaris)
IL15 [extracellular region]
(Gallus gallus)
IL15 [extracellular region]
(Sus scrofa)
Cross References
ENSEMBL
ENST00000320650
,
ENST00000477265
,
ENSP00000436914
,
ENSP00000323505
,
ENSP00000296545
,
ENSP00000422271
,
ENST00000514653
,
ENSP00000377714
,
ENSP00000435462
,
ENST00000296545
,
ENST00000529613
,
ENST00000394159
OpenTargets
ENSG00000164136
HPA
ENSG00000164136-IL15
PRO
P40933
Pharos - Targets
P40933
GlyGen
P40933
PDB
2Z3R
,
4GS7
,
2Z3Q
,
2XQB
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14784 IL2RB
4
p-Y364,Y418,Y536-IL2RB [plasma membrane]
(R-HSA-452093)
IL2RB [plasma membrane]
(R-HSA-197876)
p-Y-IL2RB [cytosol]
(R-HSA-9009733)
IL2RB [endosome]
(R-HSA-8983172)
0.658
3
UniProt:Q13261 IL15RA
2
IL15RA [endosome]
(R-HSA-8983117)
IL15RA [plasma membrane]
(R-HSA-449122)
0.656
5
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
