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IL15 [extracellular region]
Stable Identifier
R-HSA-447242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Interleukin-15, IL15_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15 binds IL15RA (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:JAK3 translocates from the plasma membrane to the endosome (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:IL2RB:JAK1:IL2RG:p-JAK3:p-Y-SHC1:GRB2 binds GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 binds STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:STAT3,STAT5,(STAT3:STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 binds GRB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:p-Y-GAB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1 [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1 (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL2RB and IL2RG are phosphorylated (Homo sapiens)
IL15:IL15RA:IL2RB:p-Y-JAK1:IL2RG:p-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
p-Y-STAT3 and p-STAT5 dissociates from IL15:IL15RA:IL2RB:p-JAK1:IL2RG:p-JAK3:p-Y-STAT3:p-STAT5 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-STAT3,p-STAT5,(p-Y-STAT3:p-STAT5) [plasma membrane] (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 [plasma membrane] (Homo sapiens)
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40933 IL15
Gene Names
IL15
Chain
signal peptide:1-29, propeptide:30-48, chain:49-162
Reference Genes
BioGPS Gene:3600 IL15
COSMIC (genes):IL15 IL15
CTD Gene:3600 IL15
dbSNP Gene:3600 IL15
ENSEMBL:ENSG00000164136 IL15
HGNC:5977 IL15
KEGG Gene (Homo sapiens):3600 IL15
Monarch:3600 IL15
NCBI Gene:3600 IL15
OMIM:600554 IL15
UCSC:P40933 IL15
Reference Transcript
RefSeq:NM_000585.4 IL15
RefSeq:NM_172175.2 IL15
Other Identifiers
0002370463
0002450541
0003140138
0104810463
1036_at
11725255_a_at
11740881_x_at
11759832_a_at
16970971
205992_s_at
217371_s_at
2745290
2745291
2745292
2745293
2745294
2745296
2745301
2745302
2745307
2745308
2745309
2745310
2745311
2745312
2745313
2745314
2745315
2745316
2745317
2745320
2745322
2745323
2745324
2745325
2745326
3600
38488_s_at
66883_r_at
8097553
A_14_P113197
GE79677
GO:0001819
GO:0001866
GO:0002376
GO:0003674
GO:0005125
GO:0005126
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005768
GO:0005794
GO:0005829
GO:0006464
GO:0006810
GO:0006950
GO:0006954
GO:0006955
GO:0007155
GO:0007165
GO:0007260
GO:0007267
GO:0007568
GO:0008150
GO:0008283
GO:0008284
GO:0009058
GO:0009986
GO:0014732
GO:0016192
GO:0016607
GO:0021700
GO:0030154
GO:0030212
GO:0030225
GO:0031410
GO:0031667
GO:0032740
GO:0032819
GO:0032825
GO:0034105
GO:0035723
GO:0042102
GO:0042119
GO:0042531
GO:0042592
GO:0043226
GO:0044281
GO:0045062
GO:0045580
GO:0048469
GO:0048535
GO:0048662
GO:0048856
GO:0050691
GO:0050729
GO:0050731
GO:0050766
GO:0050778
GO:0071305
GO:0120163
GO:1904100
HMNXSV003050130
Hs.168132.2.S1_3p_a_at
ILMN_1724181
ILMN_1785312
ILMN_2273053
ILMN_2369221
PH_hs_0010067
TC04000693.hg
TC04002235.hg
U14407_at
g10835152_3p_x_at
Participates
as a component of
IL15:IL15RA [plasma membrane] (Homo sapiens)
IL15:IL2RB:JAK1:IL2RG:JAK3 [plasma membrane] (Homo sapiens)
as an input of
IL15 binds IL15RA (Homo sapiens)
IL15 binds IL2RB:JAK1 and IL2RG:JAK3 (Homo sapiens)
Other forms of this molecule
IL15 [endosome]
Inferred To
Il15 [extracellular region]
(Mus musculus)
Il15 [extracellular region]
(Rattus norvegicus)
il15 [extracellular region]
(Danio rerio)
IL15 [extracellular region]
(Bos taurus)
IL15 [extracellular region]
(Canis familiaris)
IL15 [extracellular region]
(Gallus gallus)
IL15 [extracellular region]
(Sus scrofa)
Cross References
RefSeq
NP_751915.1
,
NP_000576.1
OpenTargets
ENSG00000164136
HPA
ENSG00000164136-IL15
GeneCards
P40933
Ensembl
ENSP00000422271
,
ENSP00000436914
,
ENST00000320650
,
ENSP00000323505
,
ENSG00000164136
,
ENST00000529613
,
ENSP00000435462
,
ENSP00000296545
,
ENST00000477265
,
ENST00000394159
,
ENST00000514653
,
ENSP00000377714
,
ENST00000296545
PRO
P40933
Orphanet
28518
PDB
2XQB
,
4GS7
,
2Z3Q
,
2Z3R
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14784 IL2RB
4
p-Y-IL2RB [cytosol]
(R-HSA-9009733)
IL2RB [endosome]
(R-HSA-8983172)
IL2RB [plasma membrane]
(R-HSA-197876)
p-Y364,Y418,Y536-IL2RB [plasma membrane]
(R-HSA-452093)
0.658
3
UniProt:Q13261 IL15RA
2
IL15RA [endosome]
(R-HSA-8983117)
IL15RA [plasma membrane]
(R-HSA-449122)
0.656
5
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