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p-4S-BMPR1A [plasma membrane]
Stable Identifier
R-HSA-201448
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-S215,S216,S218,S220-BMPR1A, Phospho-Bone morphogenetic protein receptor type IA, BMRA_HUMAN, BMPR1A
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
Activated type I receptor phosphorylates R-Smad1/5/8 directly (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
An anchoring protein, Endofin, recruits R-Smad1/5/8 (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:SMAD1/5/8 [early endosome membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
I-Smad competes with R-Smad1/5/8 for type I receptor (Homo sapiens)
BMP2:BMP type II receptor:Phospho-BMP type I receptor:I-SMAD [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
Phospho-R-Smad1/5/8 dissociates from the receptor complex (Homo sapiens)
BMP:p-BMPR:Endofin [early endosome membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
BMP:p-BMPR:Endofin:p-2S-SMAD1/5/8 [early endosome membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
Type II receptor phosphorylates type I receptor (Homo sapiens)
BMP:BMPRII:p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPRI dimer [plasma membrane] (Homo sapiens)
p-4S-BMPRI [plasma membrane] (Homo sapiens)
p-4S-BMPR1A [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36894 BMPR1A
Gene Names
BMPR1A, ACVRLK3, ALK3
Chain
signal peptide:1-23, chain:24-532
Reference Genes
BioGPS Gene:657 BMPR1A
COSMIC (genes):BMPR1A BMPR1A
CTD Gene:657 BMPR1A
dbSNP Gene:657 BMPR1A
ENSEMBL:ENSG00000107779 BMPR1A
ENSEMBL_homo_sapiens_GENE:ENSG00000107779.15 BMPR1A
HGNC:1076 BMPR1A
KEGG Gene (Homo sapiens):657 BMPR1A
Monarch:657 BMPR1A
NCBI Gene:657 BMPR1A
OMIM:601299 BMPR1A
UCSC:P36894 BMPR1A
Reference Transcript
RefSeq:NM_004329.2 BMPR1A
RefSeq:XM_011540103.2 BMPR1A
RefSeq:XM_011540104.2 BMPR1A
Other Identifiers
11722914_s_at
11722915_at
11722916_s_at
16706875
204832_PM_s_at
204832_s_at
213578_PM_at
213578_at
227273_PM_at
227273_at
230979_PM_at
230979_at
242731_PM_x_at
242731_x_at
2973634
2973636
2973638
2973639
2973640
2973642
2973644
2973645
3256071
3256072
3256075
3256092
3256100
3256101
3256105
3256106
3256111
3256112
3256118
3256119
3256121
3256122
3256123
3256124
3256126
3256127
3256128
3256129
3256130
3256131
3256132
3256133
3256134
3256135
3256136
3256143
3394965
3394967
3394968
3394969
3394970
39565_at
58485_at
61079_at
65688_at
657
7928855
7952305
80703_at
A_19_P00803411
A_19_P00804767
A_19_P00805548
A_23_P1431
A_24_P527404
A_33_P3219256
GE507477
GE60368
GO:0000166
GO:0001525
GO:0001649
GO:0001701
GO:0001707
GO:0001756
GO:0001880
GO:0002053
GO:0002062
GO:0002376
GO:0003007
GO:0003148
GO:0003151
GO:0003161
GO:0003171
GO:0003183
GO:0003186
GO:0003203
GO:0003215
GO:0003222
GO:0003223
GO:0003272
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005025
GO:0005515
GO:0005524
GO:0005886
GO:0005901
GO:0006351
GO:0006355
GO:0006468
GO:0006955
GO:0007178
GO:0007179
GO:0007389
GO:0007398
GO:0007399
GO:0007492
GO:0007507
GO:0009897
GO:0009950
GO:0009952
GO:0009953
GO:0009986
GO:0010628
GO:0010629
GO:0014032
GO:0014912
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0021953
GO:0021983
GO:0021998
GO:0022414
GO:0023052
GO:0030154
GO:0030324
GO:0030425
GO:0030501
GO:0030509
GO:0032915
GO:0035019
GO:0035137
GO:0035912
GO:0036122
GO:0036211
GO:0042475
GO:0042733
GO:0042803
GO:0043025
GO:0043167
GO:0043235
GO:0045669
GO:0045944
GO:0046332
GO:0046872
GO:0048339
GO:0048352
GO:0048368
GO:0048378
GO:0048382
GO:0048568
GO:0048589
GO:0048598
GO:0048856
GO:0048870
GO:0050673
GO:0050679
GO:0050768
GO:0051148
GO:0051171
GO:0051216
GO:0060021
GO:0060043
GO:0060045
GO:0060089
GO:0060255
GO:0060391
GO:0060412
GO:0060896
GO:0060914
GO:0060928
GO:0061626
GO:0071363
GO:0071773
GO:0098802
GO:0098821
GO:0140096
GO:0141091
GO:1902895
GO:1904414
GO:1904707
GO:1905285
GO:1990712
GO:2000772
HMNXSV003017063
Hs.150647.0.A1_3p_at
Hs.155764.0.S1_3p_at
Hs.323099.0.A1_3p_at
ILMN_1706957
ILMN_2095577
PH_hs_0027543
TC10000609.hg
TC11002378.hg
Z22535_at
g4757853_3p_a_at
Participates
as a member of
p-4S-BMPRI [plasma membrane] (Homo sapiens)
Other forms of this molecule
BMPR1A [plasma membrane]
Inferred To
phospho-BMPR1A [plasma membrane]
(Canis familiaris)
phospho-BMPR1A [plasma membrane]
(Gallus gallus)
phospho-p-4S-BMPR1A [plasma membrane]
(Bos taurus)
phospho-p-4S-BMPR1A [plasma membrane]
(Caenorhabditis elegans)
phospho-p-4S-BMPR1A [plasma membrane]
(Danio rerio)
phospho-p-4S-BMPR1A [plasma membrane]
(Drosophila melanogaster)
phospho-p-4S-BMPR1A [plasma membrane]
(Mus musculus)
phospho-p-4S-BMPR1A [plasma membrane]
(Rattus norvegicus)
phospho-p-4S-BMPR1A [plasma membrane]
(Sus scrofa)
phospho-p-4S-BMPR1A [plasma membrane]
(Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-serine at 215
Coordinate
215
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 216
Coordinate
216
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 218
Coordinate
218
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 220
Coordinate
220
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_011538406.1
,
NP_004320.2
,
XP_011538405.1
ZINC - World Drugs
BMR1A_HUMAN
Guide to Pharmacology - Targets
1786
OpenTargets
ENSG00000107779
ZINC - FDA approved
BMR1A_HUMAN
ZINC - Substances
BMR1A_HUMAN
ZINC - Biogenic
BMR1A_HUMAN
ZINC target
P36894
PRO
P36894
PDB
2QJ9
,
2H62
,
2GOO
,
3NH7
,
2QJA
,
2H64
,
3QB4
,
2K3G
,
1ES7
,
1REW
,
2QJB
HPA
ENSG00000107779-BMPR1A
GeneCards
P36894
Ensembl
ENST00000636056
,
ENSG00000107779
,
ENST00000638429
,
ENSP00000489707
,
ENSP00000361107
,
ENST00000372037
,
ENST00000635816
,
ENSP00000492290
,
ENSP00000490273
Pharos - Targets
P36894
Orphanet
15372
ZINC - Predictions - Purchasable
BMR1A_HUMAN
HMDB Protein
HMDBP01209
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P12644 BMP4
4
BMP4 [extracellular region]
(R-HSA-8858573)
BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956775)
p-BMP4 [endoplasmic reticulum lumen]
(R-HSA-8956944)
BMP4(20-408) [extracellular region]
(R-HSA-2396280)
0.609
2
UniProt:P37173 TGFBR2
9
TGFBR2 Y470D [plasma membrane]
(R-HSA-3640905)
TGFBR2 E526Q [plasma membrane]
(R-HSA-3645770)
TGFBR2 D522N [plasma membrane]
(R-HSA-3640907)
TGFBR2 R528H [plasma membrane]
(R-HSA-3640894)
TGFBR2 R528C [plasma membrane]
(R-HSA-3640899)
TGFBR2 K128Afs*3 [cytosol]
(R-HSA-3642173)
TGFBR2 K128Sfs*35 [cytosol]
(R-HSA-3642166)
NEDD8-K556,K567-TGFBR2 [plasma membrane]
(R-HSA-4332222)
TGFBR2 [plasma membrane]
(R-HSA-170842)
0.527
4
UniProt:P43115 PTGER3
1
PTGER3 [plasma membrane]
(R-HSA-391828)
0.527
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.527
2
UniProt:Q9NRM6 IL17RB
1
IL17RB [plasma membrane]
(R-HSA-447257)
0.527
2
UniProt:P23945 FSHR
1
FSHR [plasma membrane]
(R-HSA-391380)
0.527
2
UniProt:O60603 TLR2
3
TLR2 [plasma membrane]
(R-HSA-9637646)
TLR2 [secretory granule membrane]
(R-HSA-6804777)
TLR2 [plasma membrane]
(R-HSA-167992)
0.527
2
UniProt:Q15116 PDCD1
2
p-Y223,Y248-PDCD1 [plasma membrane]
(R-HSA-389736)
PDCD1 [plasma membrane]
(R-HSA-197604)
0.527
2
UniProt:P14778 IL1R1
1
IL1R1 [plasma membrane]
(R-HSA-197595)
0.527
2
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