Reactome | IL1B,Myr82K-Myr83K-IL1A:IL1R1

IL1B,Myr82K-Myr83K-IL1A:IL1R1

Stable Identifier

R-HSA-445753

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

Synonyms

Interleukin-1 receptor type 1 binds Interleukin 1

ReviewStatus

5/5

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Interleukin-1 receptor type 1 (IL1R1) is the receptor responsible for transmitting the inflammatory effects of Interleukin-1 (IL1).

Literature References

PubMed ID	Title	Journal	Year
2946959	The cell surface receptors for interleukin-1 alpha and interleukin-1 beta are identical Kronheim, SR, Urdal, DL, Deeley, M, Cantrell, M, Gillis, S, Hopp, TP, Henney, CS, Dower, SK	Nature	1986
8327496	Interleukin 1 signaling occurs exclusively via the type I receptor Mantovani, A, Shanebeck, K, Colotta, F, Re, F, Slack, JL, Alderson, MR, Giri, JG, Bird, TA, Sims, JE, Gayle, MA	Proc Natl Acad Sci U S A	1993