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Vitamin B1 (thiamin) metabolism
Stable Identifier
R-HSA-196819
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Vitamin B1 (thiamin) metabolism (Homo sapiens)
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Vitamin B1 (thiamin) is found naturally in certain foodstuffs such as green peas, spinach, liver, bananas, whole grains and legumes. Human diseases associated with thiamin deficiency include beriberi, due to a thiamin-deficient diet, TMRA, due to defects in the SLC19A2 transport protein, and Wernicke-Korsakoff Syndrome, associated with thiamin deficiency in alcoholism (Haas 1988). Thiamin is water-soluble so is not stored in the body. When pyrophosphorylated, thiamin is converted into the coenzyme thiamin pyrophosphate (ThPP, codecarboxylase) which plays an essential role in oxidative decarboxylation and group transfer reactions.
Literature References
PubMed ID
Title
Journal
Year
3060175
Thiamin and the brain
Haas, RH
Annu Rev Nutr
1988
Participants
Events
SLC19A2/3 transport extracellular THMN to cytosol
(Homo sapiens)
2xTPK1:Mg2+ phosphorylates THMN
(Homo sapiens)
TDPK phosphorylates ThDP to ThTP
(Homo sapiens)
THTPA:Mg2+ hydrolyzes ThTP to TDP
(Homo sapiens)
SLC25A19 transports ThDP from cytosol to mitochondrial matrix
(Homo sapiens)
Participates
as an event of
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Event Information
Go Biological Process
thiamine-containing compound metabolic process (0042723)
Orthologous Events
Vitamin B1 (thiamin) metabolism (Bos taurus)
Vitamin B1 (thiamin) metabolism (Caenorhabditis elegans)
Vitamin B1 (thiamin) metabolism (Canis familiaris)
Vitamin B1 (thiamin) metabolism (Danio rerio)
Vitamin B1 (thiamin) metabolism (Dictyostelium discoideum)
Vitamin B1 (thiamin) metabolism (Drosophila melanogaster)
Vitamin B1 (thiamin) metabolism (Gallus gallus)
Vitamin B1 (thiamin) metabolism (Mus musculus)
Vitamin B1 (thiamin) metabolism (Plasmodium falciparum)
Vitamin B1 (thiamin) metabolism (Rattus norvegicus)
Vitamin B1 (thiamin) metabolism (Saccharomyces cerevisiae)
Vitamin B1 (thiamin) metabolism (Schizosaccharomyces pombe)
Vitamin B1 (thiamin) metabolism (Sus scrofa)
Vitamin B1 (thiamin) metabolism (Xenopus tropicalis)
Authored
Jassal, B (2007-04-24)
Created
Jassal, B (2007-04-24)
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