TDPK phosphorylates ThDP to ThTP

Stable Identifier
R-HSA-997381
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
Synonyms
ThDP + ATP <-> ThTP + ADP
ReviewStatus
5/5
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TDPK phosphorylates ThDP to ThTP
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Thiamin triphosphate (ThTP) is believed to be synthesized from thiamin diphosphate (ThDP), catalyzed by ThDP kinase (TDPK), an enzyme that remains poorly characterized (Nishino et al, 1983).
Literature References
PubMed ID Title Journal Year
6311826 Enzyme system involved in the synthesis of thiamin triphosphate. I. Purification and characterization of protein-bound thiamin diphosphate: ATP phosphoryltransferase

Nishino, K, Itokawa, Y, Nishino, N, Piros, K, Cooper, JR

J Biol Chem 1983
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Catalyst Activity

thiamine-diphosphate kinase activity of TDPK [cytosol]

Physical Entity
TDPK [cytosol] (Homo sapiens)
Activity
thiamine-diphosphate kinase activity (GO:0050331)
Cross References
RHEA
Authored
Jassal, B  (2010-11-09)
Reviewed
D'Eustachio, P  (2010-11-05)
Created
Jassal, B  (2010-11-09)
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