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Biotin transport and metabolism
Stable Identifier
R-HSA-196780
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Biotin transport and metabolism (Homo sapiens)
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Biotin (Btn) is an essential cofactor in a variety of carboxylation reactions (Zempleni et al. 2009). Humans cannot synthesize Btn but it is abundant in the human diet and can be taken up from the intestinal lumen by the SLC5A6 transporter. Its uptake, intracellular translocation, covalent conjugation to apoenzymes, and salvage are described here.
Literature References
PubMed ID
Title
Journal
Year
19319844
Biotin
Wijeratne, SS
,
Hassan, YI
,
Zempleni, J
Biofactors
2009
Participants
Events
SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol
(Homo sapiens)
HLCS biotinylates 6x(PCCA:PCCB)
(Homo sapiens)
HLCS biotinylates PC:Mn2+
(Homo sapiens)
HLCS biotinylates 6xMCCC1:6xMCCC2
(Homo sapiens)
Cytoslic carboxylases translocate to mitochondrial matrix
(Homo sapiens)
HLCS biotinylates ACACA:Mn2+
(Homo sapiens)
HLCS biotinylates ACACB
(Homo sapiens)
An unknown protease degrades hCBXs
(Homo sapiens)
An unknown protease degrades ACACA
(Homo sapiens)
An unknown protease degrades ACACB
(Homo sapiens)
Mitochondrial BTD hydrolyses BCTN
(Homo sapiens)
BCTN translocates to extracellular region
(Homo sapiens)
Extracellular BTD hydrolyses BCTN
(Homo sapiens)
Participates
as an event of
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Event Information
Go Biological Process
biotin metabolic process (0006768)
Orthologous Events
Biotin transport and metabolism (Bos taurus)
Biotin transport and metabolism (Caenorhabditis elegans)
Biotin transport and metabolism (Canis familiaris)
Biotin transport and metabolism (Danio rerio)
Biotin transport and metabolism (Dictyostelium discoideum)
Biotin transport and metabolism (Drosophila melanogaster)
Biotin transport and metabolism (Gallus gallus)
Biotin transport and metabolism (Mus musculus)
Biotin transport and metabolism (Plasmodium falciparum)
Biotin transport and metabolism (Rattus norvegicus)
Biotin transport and metabolism (Saccharomyces cerevisiae)
Biotin transport and metabolism (Schizosaccharomyces pombe)
Biotin transport and metabolism (Sus scrofa)
Biotin transport and metabolism (Xenopus tropicalis)
Authored
Jassal, B (2007-04-24)
Created
Jassal, B (2007-04-24)
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