An unknown protease degrades hCBXs

Stable Identifier
R-HSA-3065959
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
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An unknown protease degrades hCBXs
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The mitochondrial holocarboxylases (hCBXs) propionyl-CoA carboxylase, methylcrotonoyl-CoA carboxylase and pyruvate carboxylase are degraded proteolytically to biocytin (BCTN aka biotinyl-lysine) or small biotinyl peptides (not shown here) (Chandler & Ballard 1985, Hymes & Wolf 1996, Hymes & Wolf 1999).
Literature References
PubMed ID Title Journal Year
8930409 Biotinidase and its roles in biotin metabolism

Hymes, J, Wolf, B

Clin. Chim. Acta 1996
10064314 Human biotinidase isn't just for recycling biotin

Hymes, J, Wolf, B

J. Nutr. 1999
2868710 Distribution and degradation of biotin-containing carboxylases in human cell lines

Ballard, FJ, Chandler, CS

Biochem. J. 1985
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Catalyst Activity

peptidase activity of unknown peptidase [mitochondrial matrix]

Physical Entity
unknown peptidase [mitochondrial matrix] (Homo sapiens)
Activity
peptidase activity (GO:0008233)
Authored
Jassal, B  (2013-02-06)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-02-06)
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