An unknown protease degrades hCBXs

Stable Identifier
R-HSA-3065959
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
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The mitochondrial holocarboxylases (hCBXs) propionyl-CoA carboxylase, methylcrotonoyl-CoA carboxylase and pyruvate carboxylase are degraded proteolytically to biocytin (BCTN aka biotinyl-lysine) or small biotinyl peptides (not shown here) (Chandler & Ballard 1985, Hymes & Wolf 1996, Hymes & Wolf 1999).

Literature References
PubMed ID Title Journal Year
10064314 Human biotinidase isn't just for recycling biotin

Hymes, J, Wolf, B

J. Nutr. 1999
8930409 Biotinidase and its roles in biotin metabolism

Hymes, J, Wolf, B

Clin. Chim. Acta 1996
2868710 Distribution and degradation of biotin-containing carboxylases in human cell lines

Chandler, CS, Ballard, FJ

Biochem. J. 1985
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
peptidase activity, acting on L-amino acid peptides of unknown peptidase [mitochondrial matrix]
Physical Entity
Activity
Authored
Reviewed
Created
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