Cytoslic carboxylases translocate to mitochondrial matrix

Stable Identifier
R-HSA-3323111
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cytoslic carboxylases translocate to mitochondrial matrix
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Once biotinylated, three halocarboxylases (hCBXs) are localised to the mitochondrial matrix. The mechanism of transfer is still unclear. Pyruvate carboxylase (PC) is required for gluconeogenesis, lipogenesis, neurotransmitter synthesis and insulin secretion; Methylcrotonyl-CoA carboxylase (MCC) is required for amino acid metabolism; propionyl-CoA carboxylase (PCC) is required for odd-chain fatty acid oxidation (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010).
Literature References
PubMed ID Title Journal Year
20153287 Holocarboxylase synthetase: correlation of protein localisation with biological function

Polyak, SW, Bailey, LM, Wallace, JC

Arch. Biochem. Biophys. 2010
9630604 Identification of holocarboxylase synthetase (HCS) proteins in human placenta

Suzuki, Y, Li, X, Narisawa, K, Sakamoto, O, Hiratsuka, M, Aoki, Y

Biochim. Biophys. Acta 1998
22123817 Selectivity in post-translational biotin addition to five human carboxylases

Ingaramo, M, Beckett, D

J. Biol. Chem. 2012
Participants
Input
Output
Participates
as an event of
Orthologous Events
Cytoslic carboxylases translocate to mitochondrial matrix (Bos taurus)
Cytoslic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)
Cytoslic carboxylases translocate to mitochondrial matrix (Canis familiaris)
Cytoslic carboxylases translocate to mitochondrial matrix (Danio rerio)
Cytoslic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)
Cytoslic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)
Cytoslic carboxylases translocate to mitochondrial matrix (Gallus gallus)
Cytoslic carboxylases translocate to mitochondrial matrix (Mus musculus)
Cytoslic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)
Cytoslic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)
Cytoslic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)
Cytoslic carboxylases translocate to mitochondrial matrix (Sus scrofa)
Cytoslic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)
Authored
Jassal, B  (2013-05-09)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-05-09)
Cite Us!