Cytosolic carboxylases translocate to mitochondrial matrix

Stable Identifier
R-HSA-3323111
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, mitochondrial matrix
ReviewStatus
5/5
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Cytosolic carboxylases translocate to mitochondrial matrix
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Once biotinylated, three halocarboxylases (hCBXs) are localised to the mitochondrial matrix. The mechanism of transfer is still unclear. Pyruvate carboxylase (PC) is required for gluconeogenesis, lipogenesis, neurotransmitter synthesis and insulin secretion; Methylcrotonyl-CoA carboxylase (MCC) is required for amino acid metabolism; propionyl-CoA carboxylase (PCC) is required for odd-chain fatty acid oxidation (Ingaramo & Beckett 2012, Hiratsuka et al. 1998, Bailey et al. 2010).
Literature References
PubMed ID Title Journal Year
20153287 Holocarboxylase synthetase: correlation of protein localisation with biological function

Bailey, LM, Wallace, JC, Polyak, SW

Arch. Biochem. Biophys. 2010
9630604 Identification of holocarboxylase synthetase (HCS) proteins in human placenta

Hiratsuka, M, Sakamoto, O, Li, X, Suzuki, Y, Aoki, Y, Narisawa, K

Biochim. Biophys. Acta 1998
22123817 Selectivity in post-translational biotin addition to five human carboxylases

Ingaramo, M, Beckett, D

J. Biol. Chem. 2012
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Output
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Event Information
Go Biological Process
protein import into mitochondrial matrix (0030150)
Orthologous Events
Cytosolic carboxylases translocate to mitochondrial matrix (Bos taurus)
Cytosolic carboxylases translocate to mitochondrial matrix (Caenorhabditis elegans)
Cytosolic carboxylases translocate to mitochondrial matrix (Canis familiaris)
Cytosolic carboxylases translocate to mitochondrial matrix (Danio rerio)
Cytosolic carboxylases translocate to mitochondrial matrix (Dictyostelium discoideum)
Cytosolic carboxylases translocate to mitochondrial matrix (Drosophila melanogaster)
Cytosolic carboxylases translocate to mitochondrial matrix (Gallus gallus)
Cytosolic carboxylases translocate to mitochondrial matrix (Mus musculus)
Cytosolic carboxylases translocate to mitochondrial matrix (Rattus norvegicus)
Cytosolic carboxylases translocate to mitochondrial matrix (Saccharomyces cerevisiae)
Cytosolic carboxylases translocate to mitochondrial matrix (Schizosaccharomyces pombe)
Cytosolic carboxylases translocate to mitochondrial matrix (Sus scrofa)
Cytosolic carboxylases translocate to mitochondrial matrix (Xenopus tropicalis)
Authored
Jassal, B  (2013-05-09)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-05-09)
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