CYP11B2 oxidises 18HCORST to ALDO

Stable Identifier
R-HSA-193965
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
18-hydroxycorticosterone + NADPH + H+ => aldosterone + NADP+ + 2H2O
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18-Hydroxycorticosterone and NADPH + H+ react to form aldosterone, NADP+, and H2O. This reaction is catalyzed by CYP11B2 associated with the inner mitochondrial membrane.

Literature References
PubMed ID Title Journal Year
2592361 Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta)

Mornet, E, Dupont, J, Vitek, A, White, PC

J Biol Chem 1989
2256920 Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism

Kawainoto, T, Mitsuuchi, Y, Ohnishi, T, Ichikawa, Y, Yokoyama, Y, Sumimoto, H, Toda, K, Miyahara, K, Kuribayashi, I, Nakao, K, Hosoda, K, Yamamoto, Y, Imura, H, Shizuta, Y

Biochem Biophys Res Commun 1990
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid hydroxylase activity of CYP11B2 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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