Reactome | CYP11B2 oxidises 18HCORST to ALDO

CYP11B2 oxidises 18HCORST to ALDO

Stable Identifier

R-HSA-193965

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial matrix, mitochondrial inner membrane

Synonyms

18-hydroxycorticosterone + 2 H(+) + O2 + 2 reduced (adrenodoxin) => aldosterone + 2 H2O + 2 oxidized (adrenodoxin), 18-hydroxycorticosterone + NADPH + H+ => aldosterone + NADP+ + 2H2O

ReviewStatus

5/5

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Metabolism (Homo sapiens)

- Biological oxidations (Homo sapiens)
  - Phase I - Functionalization of compounds (Homo sapiens)
    - Cytochrome P450 - arranged by substrate type (Homo sapiens)
      - Endogenous sterols (Homo sapiens)
        
        CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)
- Metabolism of lipids (Homo sapiens)
  - Metabolism of steroids (Homo sapiens)
    - Metabolism of steroid hormones (Homo sapiens)
      - Mineralocorticoid biosynthesis (Homo sapiens)
        
        CYP11B2 oxidises 18HCORST to ALDO (Homo sapiens)

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18-Hydroxycorticosterone and NADPH + H+ react to form aldosterone, NADP+, and H2O. This reaction is catalyzed by CYP11B2 associated with the inner mitochondrial membrane.

Literature References

PubMed ID	Title	Journal	Year
2256920	Cloning and expression of a cDNA for human cytochrome P-450aldo as related to primary aldosteronism Kawainoto, T, Mitsuuchi, Y, Ohnishi, T, Ichikawa, Y, Yokoyama, Y, Sumimoto, H, Toda, K, Miyahara, K, Kuribayashi, I, Nakao, K, Hosoda, K, Yamamoto, Y, Imura, H, Shizuta, Y	Biochem Biophys Res Commun	1990
2592361	Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta) Mornet, E, Dupont, J, Vitek, A, White, PC	J Biol Chem	1989