Reactome | HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

Stable Identifier

R-HSA-193073

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, endoplasmic reticulum membrane

Synonyms

DHA isomerizes to 4-Androstene3,17-dione

ReviewStatus

5/5

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HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

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In this two-step reaction catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane, the 3-hydroxyl group of DHA is oxidized to a keto group and the double bond in the steroid nucleus is then isomerized from the five to the 4 position. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References

PubMed ID	Title	Journal	Year
9536209	A critical review of the origin and control of adrenal androgens McKenna, TJ, Fearon, U, Clarke, D, Cunningham, SK	Baillieres Clin Obstet Gynaecol	1997
2243100	Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells Lachance, Y, Luu-The, V, Labrie, C, Simard, J, Dumont, M, de Launoit, Y, Guerin, S, Leblanc, G, Labrie, F	J Biol Chem	1990