HSD2B1 dimer, HSD3B2 dimer isomerise DHA to ANDST

Stable Identifier
Reaction [transition]
Homo sapiens
DHA isomerizes to 4-Androstene3,17-dione
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In this two-step reaction catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane, the 3-hydroxyl group of DHA is oxidized to a keto group and the double bond in the steroid nucleus is then isomerized from the five to the 4 position. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).

Literature References
PubMed ID Title Journal Year
9536209 A critical review of the origin and control of adrenal androgens

Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK

Baillieres Clin Obstet Gynaecol 1997
2243100 Characterization of human 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase gene and its expression in mammalian cells

Simard, J, de Launoit, Y, Lachance, Y, Luu-The, V, Labrie, F, Leblanc, G, Dumont, M, Labrie, C, Guerin, S

J Biol Chem 1990
Catalyst Activity

steroid delta-isomerase activity of HSD2B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]

This event is regulated
Positively by
Orthologous Events
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