In this two-step reaction catalyzed by 3beta-HSD associated with the endoplasmic reticulum membrane, the 3-hydroxyl group of DHA is oxidized to a keto group and the double bond in the steroid nucleus is then isomerized from the five to the 4 position. Corticotropin (Adrenocorticotropic hormone, ACTH) acts through the ACTH receptor called melanocortin receptor type 2 (MC2R) to stimulate steroidogenesis, increasing the production of androgens (McKenna et al, 1997).
Fearon, U, Clarke, D, McKenna, TJ, Cunningham, SK
Simard, J, de Launoit, Y, Lachance, Y, Luu-The, V, Labrie, F, Leblanc, G, Dumont, M, Labrie, C, Guerin, S
steroid delta-isomerase activity of HSD2B1 dimer, HSD3B2 dimer [endoplasmic reticulum membrane]
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