CYP27A1 27-hydroxylates CHOL

Stable Identifier
R-HSA-192123
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+
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Cholesterol CHOL), NADPH + H+, and O2 react to form 27-hydroxycholesterol (27OH-CHOL), H2O, and NADP+, in the mitochondrial matrix, catalysed by CYP27A1. 27OH-CHOL is the most abundant oxysterol in human plasma. Its formation is thought to play a central role in the mobilization of CHOL from non-hepatic tissues (Cali et al. 1991).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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