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CYP27A1 27-hydroxylates CHOL
Stable Identifier
R-HSA-192123
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
cholesterol + NADPH + H+ + O2 => 27-hydroxycholesterol + H2O + NADP+
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Biological oxidations (Homo sapiens)
Phase I - Functionalization of compounds (Homo sapiens)
Cytochrome P450 - arranged by substrate type (Homo sapiens)
Endogenous sterols (Homo sapiens)
CYP27A1 27-hydroxylates CHOL (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Bile acid and bile salt metabolism (Homo sapiens)
Synthesis of bile acids and bile salts (Homo sapiens)
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
CYP27A1 27-hydroxylates CHOL (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Cholesterol CHOL), NADPH + H+, and O2 react to form 27-hydroxycholesterol (27OH-CHOL), H2O, and NADP+, in the mitochondrial matrix, catalysed by CYP27A1. 27OH-CHOL is the most abundant oxysterol in human plasma. Its formation is thought to play a central role in the mobilization of CHOL from non-hepatic tissues (Cali et al. 1991).
Literature References
PubMed ID
Title
Journal
Year
1708392
Characterization of human sterol 27-hydroxylase. A mitochondrial cytochrome P-450 that catalyzes multiple oxidation reaction in bile acid biosynthesis.
Cali, JJ
,
Russell, DW
J Biol Chem
1991
Participants
Input
CHOL [mitochondrial matrix]
H+ [mitochondrial matrix]
NADPH [mitochondrial matrix]
O2 [mitochondrial matrix]
Output
27OH-CHOL [mitochondrial matrix]
H2O [mitochondrial matrix]
NADP+ [mitochondrial matrix]
Participates
as an event of
Synthesis of bile acids and bile salts via 27-hydroxycholesterol (Homo sapiens)
Endogenous sterols (Homo sapiens)
Catalyst Activity
steroid hydroxylase activity of CYP27A1 [mitochondrial matrix]
Physical Entity
CYP27A1 [mitochondrial matrix]
(Homo sapiens)
Activity
steroid hydroxylase activity (GO:0008395)
Orthologous Events
CYP27A1 27-hydroxylates CHOL (Bos taurus)
CYP27A1 27-hydroxylates CHOL (Canis familiaris)
CYP27A1 27-hydroxylates CHOL (Mus musculus)
CYP27A1 27-hydroxylates CHOL (Rattus norvegicus)
CYP27A1 27-hydroxylates CHOL (Sus scrofa)
Cross References
Rhea
43837
Authored
Jassal, B (2008-05-19)
Reviewed
D'Eustachio, P (2008-05-28)
Created
Jassal, B (2007-01-26)
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