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PIK3CD:PIK3R1 [cytosol]
Stable Identifier
R-HSA-1806213
Type
Complex
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF1 (M-CSF) in myeloid cells (Homo sapiens)
CSF1R-associated phosphatidylinositol 3-kinase (PI3K) phosphorylates PI(4,5)P2 (Homo sapiens)
PIK3CA,B,D:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PIK3R1:PIK3CA,B,D (PI3K), PLCG2 (PLCgamma2), SHC1 (SHC), PTPN11 (SHP2), GRB2:GAB2, GRB2:GAB3, GRAP2 (MONA), CBL:GRB2, INPP5D (SHIP1), INPPL1 (SHIP2) bind PolyUb,p-8Y-CSF1R and are activated (Homo sapiens)
PIK3CA,B,D:PIK3R1 [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI(4,5)P2 is phosphorylated to PI(3,4,5)P3 by PIK3C[1] at the plasma membrane (Homo sapiens)
PIK3C(1) [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:phospho-IRS2 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-Y-IRS2:PI3K [plasma membrane] (Homo sapiens)
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CD:PIK3R1 [cytosol] (Homo sapiens)
Participants
components
PIK3CD [cytosol]
(Homo sapiens)
PIK3R1 [cytosol]
(Homo sapiens)
Participates
as a member of
PI3K alpha, gamma [cytosol] (Homo sapiens)
PIK3CA,B,D:PIK3R1 [cytosol] (Homo sapiens)
PIK3C(1) [cytosol] (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
as an input of
p-PIK3AP1 (p-BCAP) binds PIK3CD:PIK3R1 (PI3K delta) (Homo sapiens)
p-CD19:VAV binds PI3K and GRB2 (Homo sapiens)
Inferred To
PIK3CD:PIK3R1 [cytosol]
(Bos taurus)
PIK3CD:PIK3R1 [cytosol]
(Canis familiaris)
PIK3CD:PIK3R1 [cytosol]
(Danio rerio)
PIK3CD:PIK3R1 [cytosol]
(Drosophila melanogaster)
PIK3CD:PIK3R1 [cytosol]
(Gallus gallus)
PIK3CD:PIK3R1 [cytosol]
(Mus musculus)
PIK3CD:PIK3R1 [cytosol]
(Rattus norvegicus)
PIK3CD:PIK3R1 [cytosol]
(Sus scrofa)
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