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SRP-dependent cotranslational protein targeting to membrane
Stable Identifier
R-HSA-1799339
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
,
endoplasmic reticulum lumen
,
endoplasmic reticulum membrane
ReviewStatus
5/5
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
General
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The process for translation of a protein destined for the endoplasmic reticulum (ER) branches from the canonical cytoslic translation process at the point when a nascent polypeptide containing a hydrophobic signal sequence is exposed on the surface of the cytosolic ribosome:mRNA:peptide complex. The signal sequence mediates the interaction of this complex with a cytosolic signal recognition particle (SRP) to form a complex which in turn docks with an SRP receptor complex on the ER membrane. There the ribosome complex is transferred from the SRP complex to a translocon complex embedded in the ER membrane and reoriented so that the nascent polypeptide protrudes through a pore in the translocon into the ER lumen. Translation, which had been halted by SRP binding, now resumes, the signal peptide is cleaved from the polypeptide, and elongation proceeds, with the growing polypeptide oriented into the ER lumen.
Participants
Events
Synthesis of nascent polypeptide containing signal sequence
(Homo sapiens)
Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
(Homo sapiens)
The SRP receptor binds the SRP:nascent peptide:ribosome complex
(Homo sapiens)
Signal-containing nascent peptide translocates to endoplasmic reticulum
(Homo sapiens)
Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
(Homo sapiens)
Participates
as an event of
Translation (Homo sapiens)
Event Information
Go Biological Process
SRP-dependent cotranslational protein targeting to membrane (0006614)
Orthologous Events
SRP-dependent cotranslational protein targeting to membrane (Bos taurus)
SRP-dependent cotranslational protein targeting to membrane (Caenorhabditis elegans)
SRP-dependent cotranslational protein targeting to membrane (Canis familiaris)
SRP-dependent cotranslational protein targeting to membrane (Danio rerio)
SRP-dependent cotranslational protein targeting to membrane (Dictyostelium discoideum)
SRP-dependent cotranslational protein targeting to membrane (Drosophila melanogaster)
SRP-dependent cotranslational protein targeting to membrane (Gallus gallus)
SRP-dependent cotranslational protein targeting to membrane (Mus musculus)
SRP-dependent cotranslational protein targeting to membrane (Plasmodium falciparum)
SRP-dependent cotranslational protein targeting to membrane (Rattus norvegicus)
SRP-dependent cotranslational protein targeting to membrane (Saccharomyces cerevisiae)
SRP-dependent cotranslational protein targeting to membrane (Schizosaccharomyces pombe)
SRP-dependent cotranslational protein targeting to membrane (Sus scrofa)
SRP-dependent cotranslational protein targeting to membrane (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000293
Authored
May, B (2008-11-20)
Gopinathrao, G (2008-11-20)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Created
D'Eustachio, P (2011-10-23)
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