The SRP receptor binds the SRP:nascent peptide:ribosome complex

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The SRP receptor in the the endoplasmic reticulum (ER) membrane binds via its alpha subunit to the the SRP54 subunit of the Signal Recognition Particle (SRP), which itself is bound to a ribosome:mRNA:polypeptide complex. This interaction tethers the ribosome to the ER membrane, oriented so that the nacent polypeptide will traverse the ER membrane and enter the ER lumen. This process has been characterized in detail in cultured canine cells; this human event is inferred by homology from its canine counterpart.

Literature References
PubMed ID Title Journal Year
12853463 Structure, function and evolution of the signal recognition particle

Nagai, K, Oubridge, C, Kuglstatter, A, Menichelli, E, Isel, C, Jovine, L

EMBO J 2003
9631292 The role of assembly in insulin's biosynthesis

Dodson, G, Steiner, D

Curr Opin Struct Biol 1998
Participant Of
Inferred From