Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein

Stable Identifier
R-HSA-1799329
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol, endoplasmic reticulum membrane, endoplasmic reticulum lumen
ReviewStatus
5/5
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Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein
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As the signal peptide of the nascent protein enters the lumen of the endoplasmic reticulum (ER), the signal peptide is recognized and cleaved by the ER membrane-associated Signal Peptidase. Translation of the protein then proceeds to completion.

Participants
Input
Output
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as an event of
Catalyst Activity

serine-type endopeptidase activity of Signal Peptidase [endoplasmic reticulum membrane]

Physical Entity
Signal Peptidase [endoplasmic reticulum membrane] (Homo sapiens)
Activity
serine-type endopeptidase activity (GO:0004252)
Inferred From
Signal Peptidase (Canis) hydrolyzes the signal peptide of Preprolactin (Bos taurus)
Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
D'Eustachio, P  (2011-10-23)
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