Signal-containing nascent peptide translocates to endoplasmic reticulum

Stable Identifier
R-HSA-1799326
Type
Reaction [dissociation]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen, endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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Signal-containing nascent peptide translocates to endoplasmic reticulum
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The Signal Recognition Particle (SRP) receptor mediates transfer of the ribosome:mRNA:nascent protein complex to the Translocon Complex. A coupled reaction (not annotated here) in which GTP molecules are hydrolyzed by the alpha subunit of the SRP Receptor and the SRP54 subunit of the SRP is thought to ensure release of the SRP only after the ribosome is properly reoriented. At the end of this process, the ribosome is attached to the endoplasmic reticulum (ER) membrane with its associated nascent polypeptide protruding through the Translocon Complex into the ER lumen.
Literature References
PubMed ID Title Journal Year
11964406 Endoplasmic reticulum-bound ribosomes reside in stable association with the translocon following termination of protein synthesis

Nicchitta, CV, Potter, MD

J Biol Chem 2002
9631292 The role of assembly in insulin's biosynthesis

Steiner, D, Dodson, G

Curr Opin Struct Biol 1998
18166647 The expanding role of the ER translocon in membrane protein folding

Skach, WR

J Cell Biol 2007
Participants
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Output
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as an event of
Inferred From
Translocon (canine) translocates Preprolactin (bovine) (Bos taurus)
Authored
May, B  (2008-11-20)
Gopinathrao, G  (2008-11-20)
Reviewed
Gillespie, ME  (2008-12-02)
D'Eustachio, P  (2008-12-02)
Matthews, L  (2008-12-02)
Created
D'Eustachio, P  (2011-10-23)
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