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Synthesis of nascent polypeptide containing signal sequence
Stable Identifier
R-HSA-1799335
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Synthesis of nascent polypeptide containing signal sequence (Homo sapiens)
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The synthesis of a protein destined for the endoplasmic reticulum starts with the canonical events of cytosolic translation initiation and proceeds to the point where a nascent polypeptide chain containing a signal sequence protrudes from the mRNA:ribosome complex. Merrick (2010) provides an overview of these events.
Literature References
PubMed ID
Title
Journal
Year
20444697
Eukaryotic protein synthesis: still a mystery
Merrick, WC
J Biol Chem
2010
Participants
Input
80S ribosome [cytosol]
(Homo sapiens)
mRNA [cytosol]
(Homo sapiens)
Output
ribosome:mRNA:polypeptide+signal [cytosol]
(Homo sapiens)
Participates
as an event of
SRP-dependent cotranslational protein targeting to membrane (Homo sapiens)
Authored
May, B (2008-11-20)
Gopinathrao, G (2008-11-20)
Reviewed
Gillespie, ME (2008-12-02)
D'Eustachio, P (2008-12-02)
Matthews, L (2008-12-02)
Created
D'Eustachio, P (2011-10-23)
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