The PPP1R15A (GADD34) mRNA is translated to yield PPP1R15A protein which then associates with the cytosolic faces of the endoplasmic reticulum membrane and the mitochondrial outer membrane (inferred from the mouse homolog). The PPP1R15A mRNA contains 2 upstream ORFs (uORFs) that limit translation of the downstream PPP1R15A coding region (inferred from the mouse homolog). During certain stresses, EIF2S1 (eIF2-alpha) is phosphorylated, causing a reduction in initiation at the uORFs and increased translation of the PPP1R15A coding region (inferred from mouse homologs).
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