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LPL [extracellular region]
Stable Identifier
R-HSA-174605
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
lipoprotein lipase monomer
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of white adipocyte differentiation (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Epigenetic regulation by WDR5-containing histone modifying complexes (Homo sapiens)
Epigenetic regulation of gene expression by MLL3 and MLL4 complexes (Homo sapiens)
Epigenetic regulation of adipogenesis genes by MLL3 and MLL4 complexes (Homo sapiens)
MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis (Homo sapiens)
LPL gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of fat-soluble vitamins (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LPL hydrolyses TGs from mature CMs (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
Sensory Perception (Homo sapiens)
Visual phototransduction (Homo sapiens)
Retinoid metabolism and transport (Homo sapiens)
LPL hydrolyses TGs from mature CMs (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
Transport of small molecules (Homo sapiens)
Plasma lipoprotein assembly, remodeling, and clearance (Homo sapiens)
Plasma lipoprotein remodeling (Homo sapiens)
Assembly of active LPL and LIPC lipase complexes (Homo sapiens)
GPIHBP1 binds HSPG:LPL dimer (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
HSPG binds LPL dimer (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
Chylomicron remodeling (Homo sapiens)
chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols (Homo sapiens)
GPIHBP1:HSPG:LPL dimer [plasma membrane] (Homo sapiens)
HSPG:LPL dimer [plasma membrane] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
LPL dimer [extracellular region] (Homo sapiens)
LPL [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06858 LPL
Gene Names
LPL, LIPD
Chain
signal peptide:1-27, chain:28-475
Reference Genes
BioGPS Gene:4023 LPL
COSMIC (genes):LPL LPL
CTD Gene:4023 LPL
dbSNP Gene:4023 LPL
ENSEMBL:ENSG00000175445 LPL
HGNC:6677 LPL
KEGG:hsa:4023 LPL
Monarch:4023 LPL
NCBI Gene:4023 LPL
OMIM:609708 LPL
UCSC:P06858 LPL
Reference Transcript
RefSeq:NM_000237.2 LPL
Other Identifiers
11718972_at
11718973_at
11718974_at
17066278
203548_PM_s_at
203548_s_at
203549_PM_s_at
203549_s_at
3088485
3088487
3088489
3088490
3088491
3088496
3088497
3088498
3088499
3088500
3088501
3088502
3088503
3088507
3088509
3088510
3088511
3088512
3088513
4023
41209_at
8144917
A_23_P146233
GE79485
GO:0003824
GO:0004465
GO:0004620
GO:0004806
GO:0005102
GO:0005509
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0006629
GO:0006631
GO:0006633
GO:0006641
GO:0006644
GO:0008201
GO:0008970
GO:0009617
GO:0009749
GO:0009986
GO:0010744
GO:0010884
GO:0010886
GO:0010890
GO:0016042
GO:0016298
GO:0016787
GO:0019433
GO:0031670
GO:0032722
GO:0032731
GO:0032755
GO:0032760
GO:0034185
GO:0034361
GO:0034371
GO:0034372
GO:0034375
GO:0042627
GO:0042632
GO:0042803
GO:0043395
GO:0043495
GO:0045600
GO:0046872
GO:0050729
GO:0052689
GO:0052739
GO:0052740
GO:0055096
GO:0060090
GO:0070328
GO:0071398
GO:0071813
GO:1902494
GO:1904179
GO:2000343
HMNXSV003003336
Hs.180878.0.A1_3p_a_at
ILMN_1786444
M15856_at
PH_hs_0010704
TC08000149.hg
g4557726_3p_a_at
Participates
as an output of
LPL gene expression is stimulated by PPARG:RXRA:MLL4,(MLL3)-ASCOM complex (Homo sapiens)
Expression of Lipoprotein lipase (LPL) (Homo sapiens)
PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer (Homo sapiens)
as a component of
LPL dimer [extracellular region] (Homo sapiens)
Inferred To
Dmel\CG10163 [extracellular region]
(Drosophila melanogaster)
Dmel\CG18641 [extracellular region]
(Drosophila melanogaster)
anon-SAGE:Wang-122 [extracellular region]
(Drosophila melanogaster)
Dmel\CG10357 [extracellular region]
(Drosophila melanogaster)
CG31686 [extracellular region]
(Drosophila melanogaster)
Dmel\CG17191 [extracellular region]
(Drosophila melanogaster)
CG9966 [extracellular region]
(Drosophila melanogaster)
Dmel\CG6675 [extracellular region]
(Drosophila melanogaster)
LPL [extracellular region]
(Bos taurus)
LPL [extracellular region]
(Canis familiaris)
LPL [extracellular region]
(Danio rerio)
LPL [extracellular region]
(Drosophila melanogaster)
LPL [extracellular region]
(Gallus gallus)
LPL [extracellular region]
(Mus musculus)
LPL [extracellular region]
(Rattus norvegicus)
LPL [extracellular region]
(Sus scrofa)
LPL [extracellular region]
(Xenopus tropicalis)
sxe2 [extracellular region]
(Drosophila melanogaster)
Homologues of LPL [extracellular region]
(Drosophila melanogaster)
DmelL2 [extracellular region]
(Drosophila melanogaster)
Dmel\CG5162 [extracellular region]
(Drosophila melanogaster)
Dmel\CG6295 [extracellular region]
(Drosophila melanogaster)
Dmel\CG7367 [extracellular region]
(Drosophila melanogaster)
Dmel\CG6283 [extracellular region]
(Drosophila melanogaster)
cg5665 [extracellular region]
(Drosophila melanogaster)
Dmel\CG4582 [extracellular region]
(Drosophila melanogaster)
chr2L_10724193_10724543.0 [extracellular region]
(Drosophila melanogaster)
Dmel\CG6472 [extracellular region]
(Drosophila melanogaster)
DmelL7 [extracellular region]
(Drosophila melanogaster)
Dmel\CG10116 [extracellular region]
(Drosophila melanogaster)
Dmel\CG17192 [extracellular region]
(Drosophila melanogaster)
Dmel\CG17292 [extracellular region]
(Drosophila melanogaster)
Dmel\CG6847 [extracellular region]
(Drosophila melanogaster)
CT41369 [extracellular region]
(Drosophila melanogaster)
Dmel\CG13282 [extracellular region]
(Drosophila melanogaster)
DmelL1 [extracellular region]
(Drosophila melanogaster)
Dmel\CG1986 [extracellular region]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000650287
,
ENSP00000497642
OpenTargets
ENSG00000175445
HPA
ENSG00000175445-LPL
ZINC - Substances
LIPL_HUMAN
ZINC target
P06858
PRO
P06858
Pharos - Targets
P06858
GlyGen
P06858
Orphanet
LPL
ZINC - Predictions - Purchasable
LIPL_HUMAN
HMDB Protein
HMDBP00310
PDB
6OAZ
,
6E7K
,
6OAU
,
6WN4
,
6OB0
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IV16 GPIHBP1
3
cleaved GPI-GPIHBP1 [extracellular region]
(R-HSA-8941062)
GPI-GPIHBP1 [plasma membrane]
(R-HSA-8940783)
GPIHBP1 [plasma membrane]
(R-HSA-5216067)
0.744
7
ChEBI:91111 1,2-DI-O-LAURYL-RAC-GLYCERO-3-GLUTARIC ACID 6'-METHYLRESORUFIN ESTER
0.623
6
UniProt:Q9UMY4 SNX12
0.556
3
UniProt:Q9UI10 EIF2B4
1
EIF2B4 [cytosol]
(R-HSA-72521)
0.556
3
UniProt:O43493-5 O434935
0.556
3
UniProt:C9J082 C9J082
0.556
3
UniProt:O00746 NME4
1
NME4 [mitochondrial inner membrane]
(R-HSA-60026)
0.556
3
UniProt:Q8IYM2 SLN12
0.556
3
UniProt:CCDC26 A0A024R9H7
0.556
3
UniProt:Q8TAS3 Q8TAS3
0.556
3
UniProt:Q8NFB2 T185A
0.556
3
UniProt:Q8N0U8 VKORC1L1
1
VKORC1L1 [endoplasmic reticulum membrane]
(R-HSA-2980944)
0.556
3
UniProt:O14744 PRMT5
3
PRMT5 [cytosol]
(R-HSA-191876)
PRMT5 [nucleoplasm]
(R-HSA-5205609)
p-Y297,304,307-PRMT5 [nucleoplasm]
(R-HSA-5211300)
0.556
3
UniProt:O00233 PSMD9
1
PSMD9 [cytosol]
(R-HSA-68810)
0.556
3
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