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EIF2B4 [cytosol]
Stable Identifier
R-HSA-72521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2B-delta, translation initiation factor 2B delta subunit , eIF-2B GDP-GTP exchange factor, delta subunit, Translation initiation factor eIF-2B delta subunit, eIF-2B GDP-GTP exchange factor
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UI10 EIF2B4
Gene Names
EIF2B4, EIF2BD
Chain
initiator methionine:1, chain:2-523
Reference Genes
BioGPS Gene:8890 EIF2B4
COSMIC (genes):EIF2B4 EIF2B4
CTD Gene:8890 EIF2B4
dbSNP Gene:8890 EIF2B4
ENSEMBL:ENSG00000115211.17 EIF2B4
HGNC:3260 EIF2B4
KEGG Gene (Homo sapiens):8890 EIF2B4
Monarch:8890 EIF2B4
NCBI Gene:8890 EIF2B4
OMIM:606687 EIF2B4
UCSC:Q9UI10 EIF2B4
Reference Transcript
RefSeq:NM_001318967.1 EIF2B4
RefSeq:NM_172195.3 EIF2B4
RefSeq:NM_015636.3 EIF2B4
RefSeq:NM_001034116.1 EIF2B4
RefSeq:NM_001318966.1 EIF2B4
RefSeq:NM_001318965.1 EIF2B4
RefSeq:NM_001318968.1 EIF2B4
Other Identifiers
11749414_a_at
11755415_a_at
16895807
209429_PM_x_at
209429_x_at
215482_PM_s_at
215482_s_at
2545751
2545752
2545753
2545756
2545758
2545759
2545762
2545764
2545766
2545767
2545771
2545774
2545776
2545777
2545778
2545779
2545780
2545781
2545782
2545783
2545784
32659_at
8051097
8890
A_23_P154058
GE55198
GO:0001541
GO:0002376
GO:0003743
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005851
GO:0006412
GO:0006413
GO:0006417
GO:0009408
GO:0009749
GO:0014003
GO:0022414
GO:0023052
GO:0030154
GO:0031369
GO:0042552
GO:0043434
GO:0044237
GO:0045182
GO:0048856
GO:0050852
GO:0098772
HMNXSV003011029
Hs.169474.2.S1_3p_a_at
ILMN_1687430
ILMN_1748157
ILMN_2356672
PH_hs_0010106
TC02001683.hg
Participates
as a component of
eIF2B subunits complex [cytosol] (Homo sapiens)
Inferred To
EIF2B4 [cytosol]
(Bos taurus)
EIF2B4 [cytosol]
(Canis familiaris)
EIF2B4 [cytosol]
(Gallus gallus)
EIF2B4 [cytosol]
(Plasmodium falciparum)
EIF2B4 [cytosol]
(Sus scrofa)
eif-2bdelta [cytosol]
(Caenorhabditis elegans)
tif224 [cytosol]
(Schizosaccharomyces pombe)
eIF2Bdelta [cytosol]
(Drosophila melanogaster)
GCD2 [cytosol]
(Saccharomyces cerevisiae)
eif2b4 [cytosol]
(Danio rerio)
eif2b4 [cytosol]
(Dictyostelium discoideum)
eif2b4 [cytosol]
(Xenopus tropicalis)
Eif2b4 [cytosol]
(Mus musculus)
Eif2b4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001029288.1
,
NP_751945.2
,
NP_001305897.1
,
NP_001305894.1
,
NP_001305896.1
,
NP_001305895.1
,
NP_056451.3
OpenTargets
ENSG00000115211
HPA
ENSG00000115211-EIF2B4
GeneCards
Q9UI10
Ensembl
ENSG00000115211
,
ENST00000451130
,
ENSP00000233552
,
ENST00000347454
,
ENSP00000394869
,
ENSP00000394397
,
ENST00000445933
PRO
Q9UI10
Pharos - Targets
Q9UI10
Orphanet
15923
HMDB Protein
HMDBP08376
PDB
6O81
,
6O9Z
,
7L70
,
7F66
,
7D43
,
7RLO
,
6K72
,
6CAJ
,
6EZO
,
7TRJ
,
7D45
,
7KMF
,
6O85
,
7F64
,
6K71
,
7D44
,
7F67
,
7D46
,
7VLK
,
7L7G
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
UniProt:P03952 KLKB1
5
KLKB1(20-390) [extracellular region]
(R-HSA-158239)
KLKB1(20-638) [plasma membrane]
(R-HSA-158385)
KLKB1(20-390) [plasma membrane]
(R-HSA-158213)
KLKB1(391-638) [plasma membrane]
(R-HSA-158277)
KLKB1(391-638) [extracellular region]
(R-HSA-158181)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:P01019 AGT
9
AGT(36-41) [cytosol]
(R-HSA-8852193)
AGT(35-41) [cytosol]
(R-HSA-8852195)
AGT(36-41) [extracellular region]
(R-HSA-2022355)
AGT(35-41) [extracellular region]
(R-HSA-2022354)
AGT(34-40) [extracellular region]
(R-HSA-2022351)
AGT(34-42) [extracellular region]
(R-HSA-2022348)
AGT [extracellular region]
(R-HSA-1998759)
AGT(34-43) [extracellular region]
(R-HSA-2022346)
AGT(34-41) [extracellular region]
(R-HSA-374187)
0.556
3
UniProt:P06858 LPL
1
LPL [extracellular region]
(R-HSA-174605)
0.556
3
UniProt:P06821 M
8
palmitylated M2 [Golgi membrane]
(R-FLU-195741)
M2 [Golgi membrane]
(R-FLU-195770)
M2 [endoplasmic reticulum membrane]
(R-FLU-195756)
palmitylated M2 [plasma membrane]
(R-FLU-195729)
palmitylated M2 [extracellular region]
(R-FLU-196491)
M2 [endocytic vesicle membrane]
(R-FLU-195773)
M2 [endosome lumen]
(R-FLU-189151)
M2 [cytosol]
(R-FLU-169089)
0.499
3
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