Reactome | EIF2B4 [cytosol]

EIF2B4 [cytosol]

Stable Identifier

R-HSA-72521

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF2B-delta, translation initiation factor 2B delta subunit , eIF-2B GDP-GTP exchange factor, delta subunit, Translation initiation factor eIF-2B delta subunit, eIF-2B GDP-GTP exchange factor

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UI10 EIF2B4

Gene Names

EIF2B4, EIF2BD

Chain

initiator methionine:, chain:2-523

Reference Genes

BioGPS Gene:8890 EIF2B4

COSMIC (genes):EIF2B4 EIF2B4

CTD Gene:8890 EIF2B4

dbSNP Gene:8890 EIF2B4

ENSEMBL:ENSG00000115211 EIF2B4

HGNC:3260 EIF2B4

KEGG:hsa:8890 EIF2B4

Monarch:8890 EIF2B4

NCBI Gene:8890 EIF2B4

OMIM:606687 EIF2B4

UCSC:Q9UI10 EIF2B4

Reference Transcript

Other Identifiers

11749414_a_at

11755415_a_at

16895807

209429_PM_x_at

209429_x_at

215482_PM_s_at

215482_s_at

2545751

2545752

2545753

2545754

2545755

2545756

2545757

2545758

2545759

2545760

2545761

2545762

2545763

2545764

2545765

2545766

2545767

2545768

2545769

2545770

2545771

2545772

2545773

2545774

2545775

2545776

2545777

2545778

2545779

2545780

2545781

2545782

2545783

2545784

2545785

2545787

2545788

32659_at

8051097

8890

A_23_P154058

GE55198

GO:0001541

GO:0002183

GO:0002376

GO:0003743

GO:0005085

GO:0005515

GO:0005737

GO:0005829

GO:0005851

GO:0006412

GO:0006413

GO:0006417

GO:0009408

GO:0009749

GO:0014003

GO:0031369

GO:0042552

GO:0043434

GO:0045182

GO:0048856

GO:0050852

GO:0098772

HMNXSV003011029

Hs.169474.2.S1_3p_a_at

ILMN_1687430

ILMN_1748157

ILMN_2356672

PH_hs_0010106

TC02001683.hg

Participates

as a component of

eIF2B subunits complex [cytosol] (Homo sapiens)

Inferred To

EIF2B4 [cytosol] (Bos taurus)

EIF2B4 [cytosol] (Canis familiaris)

EIF2B4 [cytosol] (Gallus gallus)

EIF2B4 [cytosol] (Plasmodium falciparum)

EIF2B4 [cytosol] (Sus scrofa)

Ghost homologue of EIF2B4 [cytosol] (Danio rerio)

eif-2bdelta [cytosol] (Caenorhabditis elegans)

tif224 [cytosol] (Schizosaccharomyces pombe)

eIF2Bdelta [cytosol] (Drosophila melanogaster)

GCD2 [cytosol] (Saccharomyces cerevisiae)

eif2b4 [cytosol] (Dictyostelium discoideum)

eif2b4 [cytosol] (Xenopus tropicalis)

Eif2b4 [cytosol] (Mus musculus)

Eif2b4 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001305894.1, NP_001305895.1, NP_751945.2, NP_056451.3, NP_001029288.1, NP_001305897.1, NP_001305896.1

OpenTargets

ENSG00000115211

ENSEMBL

ENST00000347454, ENST00000451130, ENST00000445933, ENSP00000394869, ENSP00000394397, ENSP00000233552, ENSG00000115211

HPA

ENSG00000115211-EIF2B4

GeneCards

EIF2B4

PRO

Q9UI10

Pharos - Targets

Q9UI10

Orphanet

EIF2B4

GlyGen

Q9UI10

HMDB Protein

HMDBP08376

PDB

7F67, 6K72, 6EZO, 7L7G, 7L70, 7D45, 6O81, 7D46, 6O9Z, 7D43, 8TQZ, 6K71, 8TQO, 7D44, 6CAJ, 7F66, 6O85, 7F64, 7VLK, 7TRJ, 7KMF, 7RLO

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P03952 KLKB1	5	KLKB1(391-638) [extracellular region] (R-HSA-158181) KLKB1(20-390) [extracellular region] (R-HSA-158239) KLKB1(20-638) [plasma membrane] (R-HSA-158385) KLKB1(20-390) [plasma membrane] (R-HSA-158213) KLKB1(391-638) [plasma membrane] (R-HSA-158277)	0.556	3
UniProt:P31930 UQCRC1	1	UQCRC1 [mitochondrial inner membrane] (R-HSA-164284)	0.556	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.556	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.556	3
UniProt:P06858 LPL	1	LPL [extracellular region] (R-HSA-174605)	0.556	3
UniProt:P01019 AGT	7	AGT(25-32) [extracellular region] (R-HSA-374187) AGT(25-34) [extracellular region] (R-HSA-2022346) AGT [extracellular region] (R-HSA-1998759) AGT(25-31) [extracellular region] (R-HSA-2022351) AGT(25-33) [extracellular region] (R-HSA-2022348) AGT(26-32) [extracellular region] (R-HSA-2022354) AGT(27-32) [extracellular region] (R-HSA-2022355)	0.556	3
UniProt:Q15762 CD226	1	CD226 [plasma membrane] (R-HSA-197562)	0.527	2
UniProt:P21579 SYT1	7	SYT1 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-372508) SYT1 [plasma membrane] (R-HSA-168786) SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917741) SYT1 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-372514) SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane] (R-HSA-210536) SYT1 [synaptic vesicle membrane] (R-HSA-194789) SYT1 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869113)	0.527	3
UniProt:P06821 M	8	palmitylated M2 [Golgi membrane] (R-FLU-195741) M2 [Golgi membrane] (R-FLU-195770) M2 [endoplasmic reticulum membrane] (R-FLU-195756) palmitylated M2 [plasma membrane] (R-FLU-195729) palmitylated M2 [extracellular region] (R-FLU-196491) M2 [endocytic vesicle membrane] (R-FLU-195773) M2 [endosome lumen] (R-FLU-189151) M2 [cytosol] (R-FLU-169089)	0.499	3

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