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EIF2B4 [cytosol]
Stable Identifier
R-HSA-72521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF2B-delta, translation initiation factor 2B delta subunit , eIF-2B GDP-GTP exchange factor, delta subunit, Translation initiation factor eIF-2B delta subunit, eIF-2B GDP-GTP exchange factor
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Recycling of eIF2:GDP (Homo sapiens)
Formation of eIF2:GDP:eIF2B intermediate (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2 activation (Homo sapiens)
eIF2:GDP: eIF2B [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
eIF2B subunits complex [cytosol] (Homo sapiens)
EIF2B4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UI10 EIF2B4
Gene Names
EIF2B4, EIF2BD
Chain
initiator methionine:, chain:2-523
Reference Genes
BioGPS Gene:8890 EIF2B4
COSMIC (genes):EIF2B4 EIF2B4
CTD Gene:8890 EIF2B4
dbSNP Gene:8890 EIF2B4
ENSEMBL:ENSG00000115211 EIF2B4
HGNC:3260 EIF2B4
KEGG:hsa:8890 EIF2B4
Monarch:8890 EIF2B4
NCBI Gene:8890 EIF2B4
OMIM:606687 EIF2B4
UCSC:Q9UI10 EIF2B4
Reference Transcript
RefSeq:NM_001318966.1 EIF2B4
RefSeq:NM_001034116.2 EIF2B4
RefSeq:NM_001318965.1 EIF2B4
RefSeq:NM_172195.4 EIF2B4
RefSeq:NM_001318967.1 EIF2B4
RefSeq:NM_015636.3 EIF2B4
RefSeq:NM_001318968.1 EIF2B4
Other Identifiers
11749414_a_at
11755415_a_at
16895807
209429_PM_x_at
209429_x_at
215482_PM_s_at
215482_s_at
2545751
2545752
2545753
2545754
2545755
2545756
2545757
2545758
2545759
2545760
2545761
2545762
2545763
2545764
2545765
2545766
2545767
2545768
2545769
2545770
2545771
2545772
2545773
2545774
2545775
2545776
2545777
2545778
2545779
2545780
2545781
2545782
2545783
2545784
2545785
2545787
2545788
32659_at
8051097
8890
A_23_P154058
GE55198
GO:0001541
GO:0002183
GO:0002376
GO:0003743
GO:0005085
GO:0005515
GO:0005737
GO:0005829
GO:0005851
GO:0006412
GO:0006413
GO:0006417
GO:0009408
GO:0009749
GO:0014003
GO:0031369
GO:0042552
GO:0043434
GO:0045182
GO:0048856
GO:0050852
GO:0098772
HMNXSV003011029
Hs.169474.2.S1_3p_a_at
ILMN_1687430
ILMN_1748157
ILMN_2356672
PH_hs_0010106
TC02001683.hg
Participates
as a component of
eIF2B subunits complex [cytosol] (Homo sapiens)
Inferred To
EIF2B4 [cytosol]
(Bos taurus)
EIF2B4 [cytosol]
(Canis familiaris)
EIF2B4 [cytosol]
(Gallus gallus)
EIF2B4 [cytosol]
(Plasmodium falciparum)
EIF2B4 [cytosol]
(Sus scrofa)
Ghost homologue of EIF2B4 [cytosol]
(Danio rerio)
eif-2bdelta [cytosol]
(Caenorhabditis elegans)
tif224 [cytosol]
(Schizosaccharomyces pombe)
eIF2Bdelta [cytosol]
(Drosophila melanogaster)
GCD2 [cytosol]
(Saccharomyces cerevisiae)
eif2b4 [cytosol]
(Dictyostelium discoideum)
eif2b4 [cytosol]
(Xenopus tropicalis)
Eif2b4 [cytosol]
(Mus musculus)
Eif2b4 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001305894.1
,
NP_001305895.1
,
NP_751945.2
,
NP_056451.3
,
NP_001029288.1
,
NP_001305897.1
,
NP_001305896.1
OpenTargets
ENSG00000115211
ENSEMBL
ENST00000347454
,
ENST00000451130
,
ENST00000445933
,
ENSP00000394869
,
ENSP00000394397
,
ENSP00000233552
,
ENSG00000115211
HPA
ENSG00000115211-EIF2B4
GeneCards
EIF2B4
PRO
Q9UI10
Pharos - Targets
Q9UI10
Orphanet
EIF2B4
GlyGen
Q9UI10
HMDB Protein
HMDBP08376
PDB
7F67
,
6K72
,
6EZO
,
7L7G
,
7L70
,
7D45
,
6O81
,
7D46
,
6O9Z
,
7D43
,
8TQZ
,
6K71
,
8TQO
,
7D44
,
6CAJ
,
7F66
,
6O85
,
7F64
,
7VLK
,
7TRJ
,
7KMF
,
7RLO
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03952 KLKB1
5
KLKB1(391-638) [extracellular region]
(R-HSA-158181)
KLKB1(20-390) [extracellular region]
(R-HSA-158239)
KLKB1(20-638) [plasma membrane]
(R-HSA-158385)
KLKB1(20-390) [plasma membrane]
(R-HSA-158213)
KLKB1(391-638) [plasma membrane]
(R-HSA-158277)
0.556
3
UniProt:P31930 UQCRC1
1
UQCRC1 [mitochondrial inner membrane]
(R-HSA-164284)
0.556
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.556
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
UniProt:P06858 LPL
1
LPL [extracellular region]
(R-HSA-174605)
0.556
3
UniProt:P01019 AGT
7
AGT(25-32) [extracellular region]
(R-HSA-374187)
AGT(25-34) [extracellular region]
(R-HSA-2022346)
AGT [extracellular region]
(R-HSA-1998759)
AGT(25-31) [extracellular region]
(R-HSA-2022351)
AGT(25-33) [extracellular region]
(R-HSA-2022348)
AGT(26-32) [extracellular region]
(R-HSA-2022354)
AGT(27-32) [extracellular region]
(R-HSA-2022355)
0.556
3
UniProt:Q15762 CD226
1
CD226 [plasma membrane]
(R-HSA-197562)
0.527
2
UniProt:P21579 SYT1
7
SYT1 [clathrin-sculpted monoamine transport vesicle membrane]
(R-HSA-372508)
SYT1 [plasma membrane]
(R-HSA-168786)
SYT1 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-917741)
SYT1 [clathrin-sculpted glutamate transport vesicle membrane]
(R-HSA-372514)
SYT1 [clathrin-sculpted acetylcholine transport vesicle membrane]
(R-HSA-210536)
SYT1 [synaptic vesicle membrane]
(R-HSA-194789)
SYT1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869113)
0.527
3
UniProt:P06821 M
8
palmitylated M2 [Golgi membrane]
(R-FLU-195741)
M2 [Golgi membrane]
(R-FLU-195770)
M2 [endoplasmic reticulum membrane]
(R-FLU-195756)
palmitylated M2 [plasma membrane]
(R-FLU-195729)
palmitylated M2 [extracellular region]
(R-FLU-196491)
M2 [endocytic vesicle membrane]
(R-FLU-195773)
M2 [endosome lumen]
(R-FLU-189151)
M2 [cytosol]
(R-FLU-169089)
0.499
3
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