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Polymerase switching on the C-strand of the telomere
Stable Identifier
R-HSA-174411
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Chromosome Maintenance (Homo sapiens)
Telomere Maintenance (Homo sapiens)
Extension of Telomeres (Homo sapiens)
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Polymerase switching on the C-strand of the telomere (Homo sapiens)
General
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After the primers are synthesized on the G-Rich strand, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA.
Literature References
PubMed ID
Title
Journal
Year
1967833
Functions of replication factor C and proliferating-cell nuclear antigen: functional similarity of DNA polymerase accessory proteins from human cells and bacteriophage T4.
Stillman, B
,
Tsurimoto, T
Proc Natl Acad Sci U S A
1990
1670772
Studies on the activator 1 protein complex, an accessory factor for proliferating cell nuclear antigen-dependent DNA polymerase delta.
Hurwitz, J
,
Kwong, AD
,
Pan, ZQ
,
Lee, SH
J Biol Chem
1991
1671046
Replication factors required for SV40 DNA replication in vitro. II. Switching of DNA polymerase alpha and delta during initiation of leading and lagging strand synthesis.
Stillman, B
,
Tsurimoto, T
J Biol Chem
1991
Participants
Events
Formation of the CTF18 complex
(Homo sapiens)
Formation of the CTF18-RFC(7s) complex
(Homo sapiens)
RFC binding displaces Pol Alpha on the C-strand of the telomere
(Homo sapiens)
Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere
(Homo sapiens)
RFC dissociates after sliding clamp formation on the C-strand of the telomere
(Homo sapiens)
Formation of Processive Complex on the C-strand of the telomere
(Homo sapiens)
Participates
as an event of
Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
Polymerase switching on the C-strand of the telomere (Bos taurus)
Polymerase switching on the C-strand of the telomere (Caenorhabditis elegans)
Polymerase switching on the C-strand of the telomere (Canis familiaris)
Polymerase switching on the C-strand of the telomere (Drosophila melanogaster)
Polymerase switching on the C-strand of the telomere (Gallus gallus)
Polymerase switching on the C-strand of the telomere (Mus musculus)
Polymerase switching on the C-strand of the telomere (Rattus norvegicus)
Polymerase switching on the C-strand of the telomere (Sus scrofa)
Polymerase switching on the C-strand of the telomere (Xenopus tropicalis)
Authored
Blackburn, EH (2006-03-10)
Seidel, J (2006-03-10)
Reviewed
Hayashi, MT (2020-04-29)
Price, C (2006-07-13)
Created
Gillespie, ME (2006-02-17)
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