Formation of Processive Complex on the C-strand of the telomere

Stable Identifier
R-HSA-174448
Type
Reaction [binding]
Species
Homo sapiens
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The loading of proliferating cell nuclear antigen (PCNA) leads to recruitment of pol delta, the process of polymerase switching. Human PCNA is a homotrimer of 36 kDa subunits that form a toroidal structure. The loading of PCNA by RFC is a key event in the transition from the priming mode to the extension mode of DNA synthesis. The processive complex is composed of the pol delta holoenzyme and PCNA (Lee and Hurwitz 1990, Podust et al. 1998). While PCNA increases the processivity of the DNA polymerase delta during telomeric C-strand synthesis in a human telomere replication model, it does not eliminate the DNA polymerase delta stalling on the G-rich template (Lormand et al. 2013).

Literature References
PubMed ID Title Journal Year
24038470 DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation

Lormand, JD, Buncher, N, Murphy, CT, Kaur, P, Lee, MY, Burgers, P, Wang, H, Kunkel, TA, Opresko, PL

Nucleic Acids Res. 2013
9822671 Replication factor C disengages from proliferating cell nuclear antigen (PCNA) upon sliding clamp formation, and PCNA itself tethers DNA polymerase delta to DNA.

Podust, VN, Tiwari, N, Stephan, S

J Biol Chem 1998
1974050 Mechanism of elongation of primed DNA by DNA polymerase delta, proliferating cell nuclear antigen, and activator 1.

Lee, SH, Hurwitz, J

Proc Natl Acad Sci U S A 1990
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