Formation of Processive Complex on the C-strand of the telomere

Stable Identifier
R-HSA-174448
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Formation of Processive Complex on the C-strand of the telomere
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The loading of proliferating cell nuclear antigen (PCNA) leads to recruitment of pol delta, the process of polymerase switching. Human PCNA is a homotrimer of 36 kDa subunits that form a toroidal structure. The loading of PCNA by RFC is a key event in the transition from the priming mode to the extension mode of DNA synthesis. The processive complex is composed of the pol delta holoenzyme and PCNA (Murakami et al.2010).

Literature References
Participants
Input
Output
Participant Of
hasEvent
Event Information
Go Biological Process
telomere maintenance via semi-conservative replication (0032201)
Orthologous Events
Formation of Processive Complex on the C-strand of the telomere (Bos taurus)
Formation of Processive Complex on the C-strand of the telomere (Caenorhabditis elegans)
Formation of Processive Complex on the C-strand of the telomere (Canis familiaris)
Formation of Processive Complex on the C-strand of the telomere (Danio rerio)
Formation of Processive Complex on the C-strand of the telomere (Dictyostelium discoideum)
Formation of Processive Complex on the C-strand of the telomere (Mus musculus)
Formation of Processive Complex on the C-strand of the telomere (Rattus norvegicus)
Formation of Processive Complex on the C-strand of the telomere (Schizosaccharomyces pombe)
Formation of Processive Complex on the C-strand of the telomere (Sus scrofa)
Formation of Processive Complex on the C-strand of the telomere (Xenopus tropicalis)
Authored
Blackburn, EH  (2006-03-10)
Seidel, J  (2006-03-10)
Reviewed
Price, C  (2006-07-13)
Created
Gillespie, ME  (2006-02-18)