CHTF18 (CTF18), a homolog of the RFC complex subunit RFC1, binds to CHTF8 (CTF8) and DSCC1 (DCC1) to form the evolutionarily conserved CTF18 complex (Merkle et al. 2003, Bermudez et al. 2003). Formation of a heterodimer between DSCC1 and CHTF8 may precede formation of a heterotrimer (Bermudez et al. 2003).