Formation of the CTF18 complex

Stable Identifier
R-HSA-9668904
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Formation of the CTF18 complex
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CHTF18 (CTF18), a homolog of the RFC complex subunit RFC1, binds to CHTF8 (CTF8) and DSCC1 (DCC1) to form the evolutionarily conserved CTF18 complex (Merkle et al. 2003, Bermudez et al. 2003). Formation of a heterodimer between DSCC1 and CHTF8 may precede formation of a heterotrimer (Bermudez et al. 2003).
Literature References
PubMed ID Title Journal Year
12766176 Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment

Merkle, CJ, Karnitz, LM, Henry-Sánchez, JT, Chen, J

J. Biol. Chem. 2003
12930902 The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA

Bermudez, VP, Maniwa, Y, Tappin, I, Ozato, K, Yokomori, K, Hurwitz, J

Proc. Natl. Acad. Sci. U.S.A. 2003
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Orthologous Events
Formation of the CTF18 complex (Bos taurus)
Formation of the CTF18 complex (Caenorhabditis elegans)
Formation of the CTF18 complex (Danio rerio)
Formation of the CTF18 complex (Drosophila melanogaster)
Formation of the CTF18 complex (Gallus gallus)
Formation of the CTF18 complex (Mus musculus)
Formation of the CTF18 complex (Rattus norvegicus)
Authored
Orlic-Milacic, M  (2019-12-02)
Reviewed
Hayashi, MT  (2020-04-29)
Created
Orlic-Milacic, M  (2019-12-02)
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