Reactome | Formation of the CTF18 complex

Formation of the CTF18 complex

Stable Identifier

R-HSA-9668904

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Cell Cycle (Homo sapiens)

- Chromosome Maintenance (Homo sapiens)
  - Telomere Maintenance (Homo sapiens)
    - Extension of Telomeres (Homo sapiens)
      - Telomere C-strand (Lagging Strand) Synthesis (Homo sapiens)
        
        Polymerase switching on the C-strand of the telomere (Homo sapiens)
        
        Formation of the CTF18 complex (Homo sapiens)

General

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CHTF18 (CTF18), a homolog of the RFC complex subunit RFC1, binds to CHTF8 (CTF8) and DSCC1 (DCC1) to form the evolutionarily conserved CTF18 complex (Merkle et al. 2003, Bermudez et al. 2003). Formation of a heterodimer between DSCC1 and CHTF8 may precede formation of a heterotrimer (Bermudez et al. 2003).

Literature References

PubMed ID	Title	Journal	Year
12766176	Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment Karnitz, LM, Merkle, CJ, Henry-Sánchez, JT, Chen, J	J. Biol. Chem.	2003
12930902	The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA Hurwitz, J, Ozato, K, Yokomori, K, Maniwa, Y, Tappin, I, Bermudez, VP	Proc. Natl. Acad. Sci. U.S.A.	2003