Formation of the CTF18-RFC(7s) complex

Stable Identifier
Reaction [binding]
Homo sapiens
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The CTF18 complex, composed of RFC1 homolog CHTF18 (CTF18), CHTF8 (CTF8) and DSCC1 (DCC1) binds to RFC2, RFC3, RFC4 and RFC5 to form the evolutionarily conserved heteroheptameric CTF18-RFC complex (CTF18-RFC(7s)), in which the RFC1 subunit of the RFC complex is replaced with the CTF18 complex (Bermudez et al. 2003, Merkle et al. 2003). CHTF18 is able to form a heteropentameric CTF18-RFC complex (CTF18-RFC(5s)) with RFC2, RFC3, RFC4 and RFC5 in the absence of CHTF8 and DSCC1 (Bermudez et al. 2003, Shiomi et al. 2004).

Literature References
PubMed ID Title Journal Year
12930902 The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA

Bermudez, VP, Maniwa, Y, Tappin, I, Ozato, K, Yokomori, K, Hurwitz, J

Proc. Natl. Acad. Sci. U.S.A. 2003
12766176 Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment

Merkle, CJ, Karnitz, LM, Henry-Sánchez, JT, Chen, J

J. Biol. Chem. 2003
15066120 The reconstituted human Chl12-RFC complex functions as a second PCNA loader

Shiomi, Y, Shinozaki, A, Sugimoto, K, Usukura, J, Obuse, C, Tsurimoto, T

Genes Cells 2004
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