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INSIG [endoplasmic reticulum membrane]
Stable Identifier
R-HSA-1655749
Type
Set [DefinedSet]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Metabolism of steroids (Homo sapiens)
Regulation of cholesterol biosynthesis by SREBP (SREBF) (Homo sapiens)
SREBP1A,1C,2 binds SCAP:INSIG:oxysterol and is retained in the endoplasmic reticulum (Homo sapiens)
INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP:INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG [endoplasmic reticulum membrane] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12242332
Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins
Brown, MS
,
Goldstein, JL
,
Yabe, D
Proc Natl Acad Sci U S A
2002
Participants
members
INSIG1 [endoplasmic reticulum membrane]
(Homo sapiens)
INSIG2 [endoplasmic reticulum membrane]
(Homo sapiens)
Participates
as a component of
SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] (Cricetulus griseus)
SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] (Homo sapiens)
INSIG:oxysterol [endoplasmic reticulum membrane] (Homo sapiens)
as an input of
SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG (Cricetulus griseus)
SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum (Homo sapiens)
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