SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane]

Stable Identifier
R-NUL-1655727
Type
Complex
Species
Cricetulus griseus
Compartment
endoplasmic reticulum membrane
General
SCAP forms a homotetramer. The C-terminal domain of SCAP binds the C-terminal domain of SREBP1A/1C/2 (SREBF1A/1C/2). Each SCAP subunit can bind cholesterol. Models show 1 SCAP : 1 SREBP : 1 INSIG.
Literature References
PubMed ID Title Journal Year
12963821 Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles

Brown, MS, Adams, CM, Goldstein, JL

Proc Natl Acad Sci U S A 2003
12842885 Reconstitution of sterol-regulated endoplasmic reticulum-to-Golgi transport of SREBP-2 in insect cells by co-expression of mammalian SCAP and Insigs

Brown, MS, Rawson, RB, Goldstein, JL, Dobrosotskaya, IY

J Biol Chem 2003
15728349 Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

Brown, MS, Ikeda, Y, Reitz, J, Feramisco, JD, Radhakrishnan, A, Goldstein, JL

Proc Natl Acad Sci U S A 2005
15452130 Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs

Brown, MS, Adams, CM, De Brabander, JK, Feramisco, JD, Reitz, J, Li, L, Goldstein, JL

J Biol Chem 2004
12202038 Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER

Brown, MS, Aebersold, R, Wright, ME, Espenshade, PJ, Yang, T, Goldstein, JL, Gong, Y, Yabe, D

Cell 2002
15899885 Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro

Brown, MS, Sun, LP, Li, L, Goldstein, JL

J Biol Chem 2005
9242699 Identification of complexes between the COOH-terminal domains of sterol regulatory element-binding proteins (SREBPs) and SREBP cleavage-activating protein

Brown, MS, Cheng, D, Ho, YK, Nohturfft, A, Sakai, J, Goldstein, JL

J Biol Chem 1997
Participants
components
Participates
as an output of
Inferred To
SREBP1A,1C,2:SCAP:cholesterol:INSIG [endoplasmic reticulum membrane] (Homo sapiens)
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