SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum

Stable Identifier
R-HSA-2317530
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane
Synonyms
SREBF1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SREBP1A,1C,2 binds SCAP:cholesterol:INSIG and is retained in the endoplasmic reticulum
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
SREBPs (SREBP1A/1C/2, SREBFs) bind SCAP in the endoplasmic reticulum membrane. Luminal loop 1 of SCAP binds cholesterol which prevents SCAP from interacting with Sec24 in the CopII coat complex and allows SCAP to interact with INSIG instead. These interactions retain SCAP:SREBP1A/1C/2 in the endoplasmic reticulum. The order of assembly of the SREBP1A/1C/2:SCAP:cholesterol:INSIG complex is unknown.
Participants
Input
Output
Participates
as an event of
Inferred From
SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG (Cricetulus griseus)
Authored
May, B  (2012-06-10)
Reviewed
Liang, G  (2012-08-26)
Created
May, B  (2012-06-13)
Cite Us!