Reactome | NDUFA10 [mitochondrial inner membrane]

NDUFA10 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 42 kDa subunit

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Aerobic respiration and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport (Homo sapiens)
    - Complex I biogenesis (Homo sapiens)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
      - Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95299 NDUFA10

Gene Names

NDUFA10

Chain

transit peptide:1-35, chain:36-355

Reference Genes

BioGPS Gene:4705 NDUFA10

COSMIC - genes:NDUFA10 NDUFA10

CTD Gene:4705 NDUFA10

dbSNP Gene:4705 NDUFA10

ENSEMBL:ENSG00000130414 NDUFA10

HGNC:7684 NDUFA10

KEGG:hsa:4705 NDUFA10

Monarch:4705 NDUFA10

NCBI Gene:4705 NDUFA10

OMIM:603835 NDUFA10

UCSC:O95299 NDUFA10

Reference Transcript

RefSeq:NM_004544.4 NDUFA10

Other Identifiers

11748707_a_at

11753028_a_at

11754964_a_at

1554719_3p_at

1554719_PM_at

1554719_at

1555548_PM_at

1555548_at

16910081

217860_PM_at

217860_at

227206_PM_at

227206_at

2606573

2606575

2606576

2606581

2606582

2606583

2606584

2606585

2606586

2606587

2606588

2606589

2606593

2606597

2606599

2606600

2606603

2606604

2606605

2606606

2606607

2606609

2606610

2606611

2606612

2606613

2606614

2606615

2606616

2606617

2606618

2606619

2606620

2606621

2606622

4705

50715_at

63681_at

65759_at

75824_at

8060063

A_23_P120182

A_24_P316489

A_24_P396881

A_24_P396889

A_33_P3351914

A_33_P3416221

GE583837

GE638692

GE79581

GE86467

GE867342

GE87261

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0006091

GO:0006120

GO:0008137

GO:0009060

GO:0016491

GO:0042776

GO:0045271

GO:0055085

GO:0055086

GO:1901135

GO:1902600

HMNXSV003004932

HMNXSV003022199

HMNXSV003036866

HMNXSV003042638

Hs.108593.0.S1_3p_at

Hs2.198271.2.S1_3p_a_at

Hs2.198271.2.S1_3p_at

Hs2.198271.3.S1_3p_at

ILMN_1791119

ILMN_2225698

PH_hs_0011678

TC02004893.hg

g4758767_3p_at

Participates

as a component of

NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)

Inferred To

NDUFA10 [mitochondrial inner membrane] (Bos taurus)

NDUFA10 [mitochondrial inner membrane] (Canis familiaris)

NDUFA10 [mitochondrial inner membrane] (Gallus gallus)

NDUFA10 [mitochondrial inner membrane] (Sus scrofa)

nuo-4 [mitochondrial inner membrane] (Caenorhabditis elegans)

ndufa10 [mitochondrial inner membrane] (Danio rerio)

ndufa10 [mitochondrial inner membrane] (Xenopus tropicalis)

ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)

Ndufa10 [mitochondrial inner membrane] (Mus musculus)

Ndufa10 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004535.1

ENSEMBL

ENST00000678158, ENST00000676929, ENST00000307300, ENSP00000504765, ENSP00000503956, ENSP00000252711, ENSP00000302321, ENSG00000130414, ENST00000252711

OpenTargets

ENSG00000130414

GeneCards

NDUFA10

HPA

ENSG00000130414-NDUFA10

PRO

O95299

Pharos - Targets

O95299

HMDB Protein

HMDBP00144

PDB

5XTC, 5XTD, 5XTI, 5XTH

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6JQN1 ACAD10	1	ACAD10 [mitochondrial matrix] (R-HSA-5695955)	0.527	2
UniProt:Q5TEU4 NDUFAF5	1	NDUFAF5 [mitochondrial inner membrane] (R-HSA-5689127)	0.527	2
UniProt:P46199 MTIF2	1	MTIF2 [mitochondrial matrix] (R-HSA-5368271)	0.527	2
UniProt:P19404 NDUFV2	1	NDUFV2 [mitochondrial inner membrane] (R-HSA-163939)	0.527	2

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