Reactome | NDUFA10 [mitochondrial inner membrane]

NDUFA10 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 42 kDa subunit

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95299 NDUFA10

Gene Names

NDUFA10

Chain

transit peptide:1-35, chain:36-355

Reference Genes

BioGPS Gene:4705 NDUFA10

COSMIC (genes):NDUFA10 NDUFA10

CTD Gene:4705 NDUFA10

dbSNP Gene:4705 NDUFA10

ENSEMBL:ENSG00000130414 NDUFA10

ENSEMBL:ENSG00000281434 NDUFA10

HGNC:7684 NDUFA10

KEGG Gene (Homo sapiens):4705 NDUFA10

Monarch:4705 NDUFA10

NCBI Gene:4705 NDUFA10

OMIM:603835 NDUFA10

UCSC:O95299 NDUFA10

Reference Transcript

RefSeq:NM_004544.3 NDUFA10

Other Identifiers

0002850239

0103940048

11748707_a_at

11753028_a_at

11754964_a_at

1555548_at

16910081

217860_at

227206_at

2606584

2606585

2606586

2606587

2606588

2606589

2606603

2606604

2606606

2606607

2606609

2606612

2606613

2606614

2606617

2606618

2606619

2606620

2606621

2606622

4705

50715_at

59529

5XTC

5XTD

5XTH

5XTI

65759_at

67045

70846

8060063

A0A024R4B3

A0A087WXC5

A_24_P316489

A_24_P396881

A_24_P396889

A_33_P3351914

AAD09755

AAH03417

AAL50984

AC013469

AC114750

AC233275

AF087661

AF453834

BC003417

C9J6X0

CAB070846

CCDS2531

CH471063

E7ESZ7

EAW71173

EAW71175

ENSG00000130414

ENSP00000252711

ENSP00000302321

ENST00000252711

ENST00000252711.6

ENST00000307300

ENST00000307300.8

EntrezGene:4705

EntrezGene:NDUFA10

F8WEH0

g4758767_3p_at

GE638692

GE79581

GE87261

GO:0003674

GO:0005575

GO:0005622

GO:0005623

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0008150

GO:0016491

GO:0022607

GO:0032981

GO:0032991

GO:0043226

GO:0055114

GO:0065003

GO:0070469

H7C2W5

H7C2X4

HGNC:7684

HPA059529

HPA067045

Hs.108593.0.S1_3p_at

Hs2.198271.2.S1_3p_a_at

Hs2.198271.3.S1_3p_at

ILMN_1758640

ILMN_1791119

ILMN_2225698

IPR015828

IPR027417

IPR031314

MIM:603835

MIM:618243

NDUFA10

NDUFA10-201

NDUFA10-202

NM_004544

NP_004535

NR_136155

NR_136156

NR_136157

PF01712

PH_hs_0011678

Q8N1B9

UPI000006FC2B

UPI000013090A

Participant Of

hasComponent

NDUFA10:FAD [mitochondrial inner membrane]

Inferred To

NDUFA10 [mitochondrial inner membrane] (Bos taurus)

NDUFA10 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFA10 [mitochondrial inner membrane] (Danio rerio)

NDUFA10 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFA10 [mitochondrial inner membrane] (Gallus gallus)

NDUFA10 [mitochondrial inner membrane] (Mus musculus)

NDUFA10 [mitochondrial inner membrane] (Rattus norvegicus)

NDUFA10 [mitochondrial inner membrane] (Sus scrofa)

NDUFA10 [mitochondrial inner membrane] (Xenopus tropicalis)

Ghost homologue of NDUFA10 [mitochondrial inner membrane] (Canis familiaris)

Cross References

RefSeq

NP_004535.1

OpenTargets

ENSG00000130414

GeneCards

O95299

PRO

O95299

Orphanet

20138

HMDB Protein

HMDBP00144

PDB

5XTI, 5XTC, 5XTH, 5XTD