Reactome | NDUFA10 [mitochondrial inner membrane]

NDUFA10 [mitochondrial inner membrane]

Stable Identifier

R-HSA-163937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH-ubiquinone oxidoreductase 42 kDa subunit

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Complex I biogenesis (Homo sapiens)
        
        Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
        
        980kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)
      - Complex I oxidises NADH to NAD+, reduces CoQ to QH2 (Homo sapiens)
        
        Complex I [mitochondrial inner membrane] (Homo sapiens)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
        
        HP subcomplex [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)
        
        NDUFA10 [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95299 NDUFA10

Gene Names

NDUFA10

Chain

transit peptide:1-35, chain:36-355

Reference Genes

BioGPS Gene:4705 NDUFA10

COSMIC (genes):NDUFA10 NDUFA10

CTD Gene:4705 NDUFA10

dbSNP Gene:4705 NDUFA10

ENSEMBL:ENSG00000130414.13 NDUFA10

HGNC:7684 NDUFA10

KEGG Gene (Homo sapiens):4705 NDUFA10

Monarch:4705 NDUFA10

NCBI Gene:4705 NDUFA10

OMIM:603835 NDUFA10

UCSC:O95299 NDUFA10

Reference Transcript

RefSeq:NM_004544.3 NDUFA10

Other Identifiers

0002850239

0103940048

11748707_a_at

11753028_a_at

11754964_a_at

1555548_PM_at

1555548_at

16910081

217860_PM_at

217860_at

227206_PM_at

227206_at

2606584

2606585

2606586

2606587

2606588

2606589

2606603

2606604

2606606

2606607

2606609

2606612

2606613

2606614

2606617

2606618

2606619

2606620

2606621

2606622

4705

50715_at

65759_at

8060063

A_24_P396881

A_24_P396889

A_33_P3351914

GE638692

GE79581

GE87261

GO:0005215

GO:0005622

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0006091

GO:0006120

GO:0007005

GO:0008137

GO:0009060

GO:0016491

GO:0032981

GO:0032991

GO:0042776

GO:0043226

GO:0055086

GO:0065003

GO:0070469

GO:1901135

HMNXSV003022199

HMNXSV003042638

Hs.108593.0.S1_3p_at

Hs2.198271.2.S1_3p_a_at

Hs2.198271.3.S1_3p_at

ILMN_1758640

ILMN_1791119

PH_hs_0011678

g4758767_3p_at

Participates

as a component of

NDUFA10:FAD [mitochondrial inner membrane] (Homo sapiens)

Inferred To

NDUFA10 [mitochondrial inner membrane] (Bos taurus)

NDUFA10 [mitochondrial inner membrane] (Canis familiaris)

NDUFA10 [mitochondrial inner membrane] (Danio rerio)

NDUFA10 [mitochondrial inner membrane] (Gallus gallus)

NDUFA10 [mitochondrial inner membrane] (Sus scrofa)

nuo-4 [mitochondrial inner membrane] (Caenorhabditis elegans)

Ghost homologue of NDUFA10 [mitochondrial inner membrane] (Xenopus tropicalis)

ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)

Ndufa10 [mitochondrial inner membrane] (Mus musculus)

Ndufa10 [mitochondrial inner membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_004535.1

OpenTargets

ENSG00000130414

HPA

ENSG00000130414-NDUFA10

GeneCards

O95299

Ensembl

ENST00000307300, ENSG00000130414, ENSP00000302321, ENSP00000504765, ENSP00000252711, ENST00000676929, ENST00000678158, ENSP00000503956, ENST00000252711

PRO

O95299

Pharos - Targets

O95299

Orphanet

20138

HMDB Protein

HMDBP00144

PDB

5XTH, 5XTD, 5XTI, 5XTC

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