Reactome | ND-42 [mitochondrial inner membrane]

ND-42 [mitochondrial inner membrane]

Stable Identifier

R-DME-163937

Type

Protein [EntityWithAccessionedSequence]

Species

Drosophila melanogaster

Compartment

mitochondrial inner membrane

Synonyms

NDUFA10, P91929

Locations in the PathwayBrowser

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Metabolism (Drosophila melanogaster)

- Aerobic respiration and respiratory electron transport (Drosophila melanogaster)
  - Respiratory electron transport (Drosophila melanogaster)
    - Complex I biogenesis (Drosophila melanogaster)
      - Intermediate 1 binds HP subcomplex to form Intermediate 2 (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
      - The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Drosophila melanogaster)
        
        315kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        315kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
      - The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Drosophila melanogaster)
        
        980kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        315kDa subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Complex I [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)
    - Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Drosophila melanogaster)
      - Complex I [mitochondrial inner membrane] (Drosophila melanogaster)
        
        815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Drosophila melanogaster)
        
        HP subcomplex [mitochondrial inner membrane] (Drosophila melanogaster)
        
        NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)
        
        ND-42 [mitochondrial inner membrane] (Drosophila melanogaster)

External Reference Information

External Reference

UniProt:P91929

Gene Names

ND-42

Reference Genes

BioGPS Gene:42591 ND-42

ENSEMBL:FBgn0019957

FlyBase:FBgn0019957

KEGG:dme:Dmel_CG6343 ND-42

Monarch:42591 ND-42

NCBI Gene:42591 ND-42

UCSC:P91929 ND-42

Reference Transcript

Other Identifiers

154477_at

1639585_a_at

42591

GO:0005515

GO:0005737

GO:0005739

GO:0005743

GO:0005747

GO:0005759

GO:0006091

GO:0006120

GO:0016491

GO:0045271

Participates

as a component of

NDUFA10:FAD [mitochondrial inner membrane] (Drosophila melanogaster)

Inferred From

NDUFA10 [mitochondrial inner membrane] (Homo sapiens)

Cross References

RefSeq

NP_732692.1, NP_524445.1, NP_001262821.1

ENSEMBL

FBtr0335194, FBpp0307181, FBpp0083570, FBpp0083571, FBtr0084172, FBtr0084173, FBgn0019957

FlyBase

FBgn0019957

PRO

P91929

PDB

8BA0, 8B9Z, 8ESZ, 8ESW

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