Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HES5 [nucleoplasm]
Stable Identifier
R-HSA-1606739
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Transcription factor HES-5, Class B basic helix-loop-helix protein 38, Hairy and enhancer of split 5, BHLHB38
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by NOTCH1 in Cancer (Homo sapiens)
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH1 PEST Domain Mutants in Cancer (Homo sapiens)
Constitutive Signaling by NOTCH1 PEST Domain Mutants (Homo sapiens)
NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH1 (Homo sapiens)
NOTCH1 Intracellular Domain Regulates Transcription (Homo sapiens)
NOTCH1 stimulates HES5 transcription (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH2 (Homo sapiens)
NOTCH2 intracellular domain regulates transcription (Homo sapiens)
NOTCH2 stimulates transcription of HES5 (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Intracellular Domain Regulates Transcription (Homo sapiens)
HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
Signaling by NOTCH4 (Homo sapiens)
NOTCH4 Intracellular Domain Regulates Transcription (Homo sapiens)
HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)
HES5 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5TA89 HES5
Gene Names
HES5, BHLHB38
Chain
chain:1-166
Reference Genes
BioGPS Gene:388585 HES5
COSMIC (genes):HES5 HES5
CTD Gene:388585 HES5
dbSNP Gene:388585 HES5
ENSEMBL:ENSG00000197921 HES5
HGNC:19764 HES5
KEGG:hsa:388585 HES5
Monarch:388585 HES5
NCBI Gene:388585 HES5
OMIM:607348 HES5
UCSC:Q5TA89 HES5
Reference Transcript
RefSeq:NM_001010926.3 HES5
Other Identifiers
11728973_at
16680690
239230_PM_at
239230_at
2392572
2392573
2392574
2392575
2392576
2392577
2392578
2392579
2392580
2392581
2392582
2392583
388585
46007_at
7911750
A_32_P234184
GE822526
GO:0000122
GO:0000785
GO:0000978
GO:0000981
GO:0001227
GO:0003677
GO:0003682
GO:0003690
GO:0005575
GO:0005634
GO:0005654
GO:0006355
GO:0006357
GO:0007155
GO:0007163
GO:0007219
GO:0007224
GO:0007399
GO:0007420
GO:0008284
GO:0009952
GO:0014003
GO:0021537
GO:0021781
GO:0021861
GO:0021915
GO:0022010
GO:0030154
GO:0030182
GO:0030509
GO:0030513
GO:0031641
GO:0042491
GO:0042531
GO:0043010
GO:0043226
GO:0045595
GO:0045608
GO:0045664
GO:0045665
GO:0045747
GO:0045892
GO:0045893
GO:0045944
GO:0046427
GO:0046983
GO:0048469
GO:0048661
GO:0048708
GO:0048709
GO:0048712
GO:0048715
GO:0048856
GO:0050678
GO:0050767
GO:0051216
GO:0060122
GO:0065003
GO:0072049
GO:0072050
GO:0072086
GO:0072282
GO:0090162
GO:0097150
GO:0140110
GO:1990837
GO:2000737
GO:2000974
GO:2000978
GO:2000981
HMNXSV003029543
Hs.57971.0.A1_3p_at
ILMN_1794742
PH_hs_0003722
PH_hs_0034290
TC01002121.hg
Participates
as an output of
NOTCH1 PEST domain mutants stimulate HES5 transcription (Homo sapiens)
NOTCH2 stimulates transcription of HES5 (Homo sapiens)
HES5 gene expression is stimulated by NOTCH3 (Homo sapiens)
HES5 gene transcription is stimulated by Notch4 (Homo sapiens)
HES5 gene expression is stimulated by NOTCH4 (Homo sapiens)
NOTCH1 stimulates HES5 transcription (Homo sapiens)
Cross References
ENSEMBL
ENST00000378453
,
ENST00000612705
,
ENSP00000367714
,
ENSP00000482150
OpenTargets
ENSG00000197921
HPA
ENSG00000197921-HES5
PRO
Q5TA89
Pharos - Targets
Q5TA89
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text