NOTCH1 PEST domain mutants stimulate HES5 transcription

Stable Identifier
R-HSA-2220966
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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NOTCH1 PEST domain mutants stimulate HES5 transcription
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NICD1 PEST domain mutants are expected to stimulate HES5 transcription in a similar manner to wild-type NICD1 (Arnett et al. 2010).
Literature References
PubMed ID Title Journal Year
20972443 Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes

McArthur, DG, Kopan, R, Blacklow, SC, Arnett, KL, Hass, M, Aster, JC, Ilagan, MXG

Nat Struct Mol Biol 2010
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm] (Homo sapiens)
Active Unit
NOTCH1 PEST Domain Mutants Coactivator Complex [nucleoplasm]
Normal reaction
NOTCH1 stimulates HES5 transcription (Homo sapiens)
Functional status

Gain of function of NOTCH1 PEST Domain Mutants Coactivator Complex:HES5 Gene [nucleoplasm]

Normal Entity
Disease Entity
Status
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
T-cell acute lymphoblastic leukemia DOID:5603
Authored
Orlic-Milacic, M  (2013-01-04)
Reviewed
Haw, R  (2013-02-10)
Created
Orlic-Milacic, M  (2012-05-03)
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