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GM2A(32-193) [lysosomal lumen]
Stable Identifier
R-HSA-1605614
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
GM2A, Ganglioside GM2 activator, SAP3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Glycosphingolipid catabolism (Homo sapiens)
Beta-galactosidases hydrolyse mobilized GM1 to mobilized GM2 (Homo sapiens)
mobilized GM1 [lysosomal lumen] (Homo sapiens)
GM2A:GM1 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
mobilized GM2 [lysosomal lumen] (Homo sapiens)
GM2A:GM2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
Beta-galactosidases hydrolyze GM2A:GA1 to GM2A:GA2 (Homo sapiens)
GM2A:GA1 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:GA2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A binds and mobilizes ligands (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:Ligands [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:GM2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
bHEXA,bHEXB hydrolyze GM2A:GA2 to GM2A:LacCer (Homo sapiens)
GM2A:GA2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:LacCer [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
bHEXA,bHEXS hydrolyze GM2A:SM2 (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:SM2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17900 GM2A
Gene Names
GM2A
Chain
signal peptide:1-23, propeptide:24-31, chain:32-193, chain:34-193
Reference Genes
BioGPS Gene:2760 GM2A
COSMIC (genes):GM2A GM2A
CTD Gene:2760 GM2A
dbSNP Gene:2760 GM2A
ENSEMBL:ENSG00000196743 GM2A
ENSEMBL_homo_sapiens_GENE:ENSG00000196743.9 GM2A
HGNC:4367 GM2A
KEGG Gene (Homo sapiens):2760 GM2A
Monarch:2760 GM2A
NCBI Gene:2760 GM2A
OMIM:613109 GM2A
UCSC:P17900 GM2A
Reference Transcript
RefSeq:NM_000405.4 GM2A
Other Identifiers
11719921_s_at
11719922_a_at
11719923_at
11747178_x_at
1559776_PM_at
1559776_at
16991210
209727_PM_at
209727_at
212737_PM_at
212737_at
215891_PM_s_at
215891_s_at
235678_PM_at
235678_at
2760
2835801
2835806
2835808
2835810
2835811
2835812
2835813
2835814
2835815
2835816
2835817
2835818
2835819
2835820
33646_PM_g_at
33646_g_at
33647_s_at
3381028
35820_PM_at
35820_at
64651_at
79200_at
8109344
A_23_P144866
A_23_P144872
A_24_P114936
A_24_P925314
A_33_P3405334
GE59878
GO:0001573
GO:0003824
GO:0004563
GO:0005215
GO:0005319
GO:0005576
GO:0005615
GO:0005764
GO:0005773
GO:0005829
GO:0005886
GO:0005975
GO:0006629
GO:0006665
GO:0006689
GO:0006869
GO:0007611
GO:0008047
GO:0009313
GO:0009898
GO:0016004
GO:0016323
GO:0016324
GO:0016787
GO:0019915
GO:0030290
GO:0031410
GO:0032428
GO:0035578
GO:0043202
GO:0043226
GO:0043231
GO:0046479
GO:0050877
GO:0050885
GO:0051651
GO:0070062
GO:0098772
GO:1901135
HMNXSV003023427
Hs.278242.3.S1_3p_s_at
Hs.39972.0.A1_3p_at
Hs2.191285.1.A1_3p_at
ILMN_2221046
PH_hs_0024412
PH_hs_0040465
TC05000839.hg
X62078_at
g183356_3p_s_at
Participates
as a component of
GM2A:LacCer [lysosomal lumen] (Homo sapiens)
GM2A:GA2 [lysosomal lumen] (Homo sapiens)
GM2A:GA1 [lysosomal lumen] (Homo sapiens)
GM2A:SM2 [lysosomal lumen] (Homo sapiens)
GM2A:Ligands [lysosomal lumen] (Homo sapiens)
GM2A:GM1 [lysosomal lumen] (Homo sapiens)
GM2A:GM2 [lysosomal lumen] (Homo sapiens)
as an output of
bHEXA,bHEXS hydrolyze GM2A:SM2 (Homo sapiens)
bHEXA hydrolyzes GM2A:GM2 to GM2A:GM3 (Homo sapiens)
as an input of
GM2A binds and mobilizes ligands (Homo sapiens)
Other forms of this molecule
GM2A(32-193) [extracellular region]
GM2A(32-193) [azurophil granule lumen]
Inferred To
mlt-8 [lysosomal lumen]
(Caenorhabditis elegans)
GM2A [lysosomal lumen]
(Bos taurus)
GM2A [lysosomal lumen]
(Canis familiaris)
GM2A [lysosomal lumen]
(Sus scrofa)
gm2a [lysosomal lumen]
(Xenopus tropicalis)
Gm2a [lysosomal lumen]
(Mus musculus)
Gm2a [lysosomal lumen]
(Rattus norvegicus)
Cross References
RefSeq
NP_000396.2
OpenTargets
ENSG00000196743
GeneCards
P17900
HPA
ENSG00000196743-GM2A
Ensembl
ENST00000357164
,
ENSG00000196743
,
ENSP00000349687
PRO
P17900
Pharos - Targets
P17900
Orphanet
16146
HMDB Protein
HMDBP01719
PDB
1PU5
,
2AF9
,
2AG9
,
2AG4
,
2AG2
,
1PUB
,
1TJJ
,
1G13
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62736 ACTA2
1
ACTA2 [cytosol]
(R-HSA-445792)
0.589
2
UniProt:Q9NP50 SHCAF
0.527
2
UniProt:Q9NU19 TB22B
0.527
2
UniProt:O95498 VNN2
3
VNN2 [plasma membrane]
(R-HSA-2980905)
GPI-VNN2 [plasma membrane]
(R-HSA-8940753)
cleaved GPI-VNN2 [extracellular region]
(R-HSA-8941027)
0.527
2
UniProt:Q96ER9 MITOK
0.527
2
UniProt:Q14943 KIR3DS1
1
KIR3DS1 [plasma membrane]
(R-HSA-2159806)
0.527
2
UniProt:Q15459 SF3A1
1
SF3A1 [nucleoplasm]
(R-HSA-71962)
0.527
2
UniProt:O43918 AIRE
0.527
2
UniProt:Q9BWG4 SSBP4
0.527
2
UniProt:Q15915 ZIC1
1
ZIC1 [nucleoplasm]
(R-HSA-9731648)
0.527
2
UniProt:Q9NWU2 GID8
1
GID8 [cytosol]
(R-HSA-9861665)
0.508
2
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