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GM2A(32-193) [lysosomal lumen]
Stable Identifier
R-HSA-1605614
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
lysosomal lumen
Synonyms
GM2A, Ganglioside GM2 activator, SAP3_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Sphingolipid metabolism (Homo sapiens)
Glycosphingolipid metabolism (Homo sapiens)
Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:GM2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
Hexosaminidase A cleaves GalNAc from GM2 to form GM3 (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
GM2A:GM2 [lysosomal lumen] (Homo sapiens)
GM2A(32-193) [lysosomal lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17900 GM2A
Gene Names
GM2A
Chain
signal peptide:1-23, propeptide:24-31, chain:32-193, chain:34-193
Reference Genes
BioGPS Gene:2760 GM2A
COSMIC (genes):GM2A GM2A
CTD Gene:2760 GM2A
dbSNP Gene:2760 GM2A
ENSEMBL:ENSG00000196743 GM2A
HGNC:4367 GM2A
KEGG Gene (Homo sapiens):2760 GM2A
Monarch:2760 GM2A
NCBI Gene:2760 GM2A
OMIM:613109 GM2A
UCSC:P17900 GM2A
Reference Transcript
RefSeq:NM_000405.4 GM2A
Other Identifiers
0004560687
11719921_s_at
11719922_a_at
11719923_at
11747178_x_at
1559776_at
16991210
209727_at
212737_at
215891_s_at
235678_at
2760
2835801
2835806
2835808
2835810
2835811
2835812
2835813
2835814
2835815
2835816
2835817
2835818
2835819
2835820
33646_g_at
33647_s_at
3381028
35820_at
64651_at
79200_at
8109344
A_23_P144866
A_23_P144872
A_24_P114936
A_24_P925314
A_33_P3405334
GE59878
GO:0001573
GO:0002376
GO:0003674
GO:0004563
GO:0005319
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005773
GO:0005886
GO:0005975
GO:0006629
GO:0006665
GO:0006687
GO:0006689
GO:0006810
GO:0006869
GO:0007611
GO:0008047
GO:0008150
GO:0009056
GO:0009313
GO:0009898
GO:0016004
GO:0016192
GO:0016323
GO:0016324
GO:0016787
GO:0016798
GO:0019915
GO:0030234
GO:0030290
GO:0031410
GO:0032428
GO:0034641
GO:0035578
GO:0043202
GO:0043226
GO:0043312
GO:0050877
GO:0050885
GO:0051345
GO:0070062
Hs.278242.3.S1_3p_s_at
Hs.39972.0.A1_3p_at
Hs2.191285.1.A1_3p_at
ILMN_1673325
ILMN_2221046
PH_hs_0024412
PH_hs_0040465
TC05000839.hg
X62078_at
g183356_3p_s_at
Participant Of
input
Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage
output
Hexosaminidase A cleaves GalNAc from GM2 to form GM3
hasComponent
GM2A:GM2 [lysosomal lumen]
Other forms of this molecule
GM2A(32-193) [extracellular region]
GM2A(32-193) [azurophil granule lumen]
Inferred To
mlt-8 [lysosomal lumen] (Caenorhabditis elegans)
GM2A [lysosomal lumen] (Bos taurus)
GM2A [lysosomal lumen] (Canis familiaris)
GM2A [lysosomal lumen] (Sus scrofa)
gm2a [lysosomal lumen] (Danio rerio)
gm2a [lysosomal lumen] (Xenopus tropicalis)
Gm2a [lysosomal lumen] (Mus musculus)
Gm2a [lysosomal lumen] (Rattus norvegicus)
Cross References
RefSeq
NP_000396.2
OpenTargets
ENSG00000196743
HPA
ENSG00000196743-GM2A
GeneCards
P17900
Ensembl
ENST00000357164
,
ENSP00000349687
,
ENSG00000196743
PRO
P17900
Orphanet
16146
HMDB Protein
HMDBP01719
PDB
2AG2
,
2AF9
,
2AG4
,
1TJJ
,
1PUB
,
2AG9
,
1G13
,
1PU5
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWU2 GID8
0.508
2
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