Reactome | cleaved GPI-VNN2 [extracellular region]

cleaved GPI-VNN2 [extracellular region]

Stable Identifier

R-HSA-8941027

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

GPI-VNN2, Vascular non-inflammatory molecule 2, VNN2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O95498 VNN2

Gene Names

VNN2

Chain

signal peptide:1-22, chain:23-493, propeptide:494-520

Reference Genes

BioGPS Gene:8875 VNN2

COSMIC (genes):VNN2 VNN2

CTD Gene:8875 VNN2

dbSNP Gene:8875 VNN2

ENSEMBL:ENSG00000112303 VNN2

ENSEMBL_homo_sapiens_GENE:ENSG00000112303.14 VNN2

HGNC:12706 VNN2

KEGG Gene (Homo sapiens):8875 VNN2

Monarch:8875 VNN2

NCBI Gene:8875 VNN2

OMIM:603571 VNN2

UCSC:O95498 VNN2

Reference Transcript

Other Identifiers

11741768_a_at

11746356_a_at

11756793_a_at

17023736

205922_PM_at

205922_at

2974636

2974637

2974638

2974641

2974643

2974644

2974646

2974647

2974648

2974649

2974650

2974654

2974655

2974656

2974657

2974658

2974659

2974660

2974664

34498_at

8129637

8875

A_23_P122724

GE56100

GO:0003824

GO:0005515

GO:0005576

GO:0005886

GO:0006575

GO:0006766

GO:0006807

GO:0015939

GO:0016020

GO:0016787

GO:0016811

GO:0017159

GO:0098552

HMNXSV003000742

ILMN_1678939

ILMN_1692546

ILMN_1758864

PH_hs_0023550

TC06002121.hg

TC06003855.hg

Participates

as a member of

proteins with cleaved GPI-anchors [extracellular region] (Homo sapiens)

Other forms of this molecule

VNN2 [plasma membrane]

GPI-VNN2 [plasma membrane]

Inferred To

cleaved GPI-VNN2 [extracellular region] (Dictyostelium discoideum)

cleaved GPI-VNN2 [extracellular region] (Gallus gallus)

VNN2 [extracellular region] (Bos taurus)

vnn2 [extracellular region] (Xenopus tropicalis)

Modified Residues

Name

L-cysteine amide (6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group) at 493

Coordinate

493

Modification

6-O-(2-aminoethylphosphono)-alpha-D-Man-(1->2)-alpha-D-Man-(1->6)-alpha-D-Man-(1->4)-alpha-D-GlcN-(1->6)-D-myo-inositol group

PsiMod Name

L-cysteine amide

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to L-cysteine amide.

Cross References

RefSeq

NP_511043.1, XP_006715656.1, NP_004656.2, NP_001229279.1, XP_016866896.1

OpenTargets

ENSG00000112303

HPA

ENSG00000112303-VNN2

GeneCards

O95498

Ensembl

ENSP00000436822, ENSP00000322276, ENST00000532053, ENST00000525270, ENSP00000436863, ENST00000525289, ENSG00000112303, ENST00000326499, ENST00000525674, ENSP00000436935, ENSP00000434077

PRO

O95498

Pharos - Targets

O95498

HMDB Protein

HMDBP12002

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292) PRKCA [plasma membrane] (R-HSA-156469)	0.556	3
UniProt:Q8N8Q8 COX18	1	COX18 [mitochondrial inner membrane] (R-HSA-5216190)	0.527	2
UniProt:Q96K12 FAR2	1	FAR2 [peroxisomal membrane] (R-HSA-390430)	0.527	2
UniProt:Q9NPG1 FZD3	1	FZD3 [plasma membrane] (R-HSA-443948)	0.527	2
UniProt:Q9NWM8 FKBP14 gene	1	FKBP14 [endoplasmic reticulum lumen] (R-HSA-535607)	0.527	2
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.527	2
UniProt:P17900 GM2A	3	GM2A(32-193) [extracellular region] (R-HSA-6806181) GM2A(32-193) [azurophil granule lumen] (R-HSA-6799160) GM2A(32-193) [lysosomal lumen] (R-HSA-1605614)	0.527	2

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