Reactome | factor X light chain propeptide [Golgi lumen]

factor X light chain propeptide [Golgi lumen]

Stable Identifier

R-HSA-159824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

F10(32-40)

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Gamma carboxylation, hypusine formation and arylsulfatase activation (Homo sapiens)
    - Gamma-carboxylation, transport, and amino-terminal cleavage of proteins (Homo sapiens)
      - Removal of aminoterminal propeptides from gamma-carboxylated proteins (Homo sapiens)
        
        Furin cleaves pro-factor X to factor X (Homo sapiens)
        
        factor X light chain propeptide [Golgi lumen] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
6871167	Complete amino acid sequence of the light chain of human blood coagulation factor X: evidence for identification of residue 63 as beta-hydroxyaspartic acid Kisiel, W, Fujikawa, K, Howald, WN, McMullen, BA, Sasagawa, T, Weinstein, B, Kwa, EY	Biochemistry	1983
836809	A comparison of human prothrombin, factor IX (Christmas factor), factor X (Stuart factor), and protein S DiScipio, RG, Yates, SG, Hermodson, MA, Davie, EW	Biochemistry	1977

External Reference Information

External Reference

UniProt:P00742 F10

Gene Names

F10

Chain

signal peptide:1-31, propeptide:32-40, chain:41-488, chain:41-179, chain:183-488, propeptide:183-234, chain:235-488

Reference Genes

BioGPS Gene:2159 F10

COSMIC (genes):F10 F10

CTD Gene:2159 F10

dbSNP Gene:2159 F10

ENSEMBL:ENSG00000126218 F10

HGNC:3528 F10

KEGG Gene (Homo sapiens):2159 F10

Monarch:2159 F10

NCBI Gene:2159 F10

OMIM:613872 F10

Reference Transcript

Other Identifiers

0005890056

11723802_at

16776798

205620_at

2159

3502440

3502441

3502444

3502447

3502450

3502452

3502453

3502455

3502456

3502457

3502458

3502459

39979_at

7970241

A_23_P205177

GE60493

GO:0003674

GO:0004252

GO:0005509

GO:0005515

GO:0005543

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0006508

GO:0006810

GO:0006888

GO:0006950

GO:0007165

GO:0007596

GO:0007598

GO:0007599

GO:0008150

GO:0008233

GO:0008236

GO:0008289

GO:0016192

GO:0016787

GO:0030335

GO:0031233

GO:0040011

GO:0043167

GO:0043226

GO:0048870

GO:0051897

GO:2000264

HMNXSV003031147

ILMN_1670708

L29433_at

PH_hs_0024025

TC13000417.hg

g9961350_3p_at

g9961350_3p_x_at

Participates

as an output of

Furin cleaves pro-factor X to factor X (Homo sapiens)

Other forms of this molecule

11xCbxE-3D-F10(41-179) [Golgi lumen]

11xCbxE-3D-F10(32-179) [Golgi lumen]

factor X heavy chain [Golgi lumen]

11xCbxE-3D-F10(32-179) [endoplasmic reticulum lumen]

factor X heavy chain [endoplasmic reticulum lumen]

3D-F10(32-179) [endoplasmic reticulum lumen]

factor X activation peptide [extracellular region]

factor X heavy chain [extracellular region]

11xCbxE-3D-F10(41-179) [extracellular region]

factor Xa heavy chain [extracellular region]

11xCbxE-3D-F10(41-179) [plasma membrane]

factor Xa heavy chain [plasma membrane]

Inferred To

Homologues of factor X light chain propeptide [Golgi lumen] (Drosophila melanogaster)

SPH161 [Golgi lumen] (Drosophila melanogaster)

f10 [Golgi lumen] (Danio rerio)

Dmel\CG33458 [Golgi lumen] (Drosophila melanogaster)

F10 [Golgi lumen] (Bos taurus)

F10 [Golgi lumen] (Canis familiaris)

F10 [Golgi lumen] (Gallus gallus)

F10 [Golgi lumen] (Mus musculus)

F10 [Golgi lumen] (Rattus norvegicus)

F10 [Golgi lumen] (Sus scrofa)

HDC06756 [Golgi lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_000495.1, NP_001299604.1, NP_001299603.1

ZINC - World Drugs

FA10_HUMAN

Guide to Pharmacology - Targets

2359

OpenTargets

ENSG00000126218

ZINC - FDA approved

FA10_HUMAN

ZINC - Substances

FA10_HUMAN

ZINC target

P00742

ZINC - Biogenic

FA10_HUMAN

PRO

P00742

GlyGen

P00742

PDB

4Y71, 1NFW, 7AHU, 2BQ6, 3LIW, 2XBV, 5JZU, 2BMG, 2XC0, 2XBW, 4Y7A, 2Y82, 2XC4, 2Y7X, 2Y7Z, 1LQD, 2J2U, 2J34, 1LPZ, 1V3X, 3SW2, 4A7I, 4Y6D, 2FZZ, 5JZ8, 2G00, 1XKB, 3FFG, 2VVC, 1EZQ, 2EI8, 1G2L, 1LPG, 5VOF, 3HPT, 5JTC, 2P16, 2P93, 2Y5F, 6Z6Q, 1IQJ, 6YYX, 3TK6, 2RA0, 4BTT, 1F0R, 3K9X, 7BMJ, 1IQH, 4BTU, 2BOH, 2PR3, 7BMI, 1P0S, 7E6J, 2CJI, 2UWP, 2P3T, 3KQC, 1MQ5, 1KSN, 2H9E, 2J94, 2J95, 1HCG, 2PHB, 3KQD, 2W26, 2VH0, 3CS7, 2VWN, 1IQL, 2VWO, 3TK5, 3ENS, 6YYW, 6Q9F, 1C5M, 2WYJ, 3M36, 4Y76, 3M37, 1NFU, 1F0S, 2VVU, 2P3F, 4Y79, 2BQ7, 2VVV, 2Y80, 2XBX, 2Y81, 2XBY, 1FXY, 3CEN, 1MQ6, 2J4I, 2XC5, 1IQF, 2W3I, 2W3K, 2GD4, 4ZH8, 1IQN, 2J38, 1IOE, 2JKH, 1XKA, 3KL6, 1NFY, 2EI6, 1FAX, 2EI7, 1Z6E, 1G2M, 2BQW, 2WYG, 4ZHA, 5JQY, 2Y5G, 1IQK, 6Z6R, 6YYY, 5VOE, 2P94, 2P95, 2Y5H, 1IQI, 1WU1, 2UWL, 2D1J, 1IQG, 2UWO, 2BOK, 1FJS, 4Y7B, 6RK9, 3KQB, 2P3U, 3Q3K, 3KQE, 1IQE, 3IIT, 2VWL, 2Q1J, 5K0H, 2VWM, 1IQM, 1LPK, 6Q9I, 2VH6, 4BTI, 1NFX

ZINC - Investigational

FA10_HUMAN

GeneCards

P00742

HPA

ENSG00000126218-F10

Ensembl

ENSP00000364709, ENSG00000126218, ENST00000375559

Pharos - Targets

P00742

Orphanet

16008

ZINC - Predictions - Purchasable

FA10_HUMAN

HMDB Protein

HMDBP02011

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UK55 SERPINA10	2	p-SERPINA10 [endoplasmic reticulum lumen] (R-HSA-8956990) SERPINA10 [endoplasmic reticulum lumen] (R-HSA-8956739)	0.558	2
UniProt:P0DPK4 NT2NC			0.556	3
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3

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