CL is hydrolyzed to MLCL by PLA2G6 (IM)

Stable Identifier
R-HSA-1482778
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
phospholipase A2 activity of PLA2G6 [mitochondrial inner membrane]
Physical Entity
Activity
Inferred From
Authored
Created