Reactome | CL is hydrolyzed to MLCL by PLA2G6 (IM)

CL is hydrolyzed to MLCL by PLA2G6 (IM)

Stable Identifier

R-HSA-1482778

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

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At the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (PLA2G6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL). This reaction is inferred from rats. PLA2G6 has also been characterized in humans (Larsson et al. 1998, Ma et al. 1999, Larsson Forsell et al. 1999).

Literature References

PubMed ID	Title	Journal	Year
9417066	Multiple splice variants of the human calcium-independent phospholipase A2 and their effect on enzyme activity Larsson, PK, Claesson, HE, Kennedy, BP	J Biol Chem	1998
10336645	The human calcium-independent phospholipase A2 gene multiple enzymes with distinct properties from a single gene Larsson Forsell, PK, Kennedy, BP, Claesson, HE	Eur J Biochem	1999
10092647	Human pancreatic islets express mRNA species encoding two distinct catalytically active isoforms of group VI phospholipase A2 (iPLA2) that arise from an exon-skipping mechanism of alternative splicing of the transcript from the iPLA2 gene on chromosome 22q13.1 Ma, Z, Wang, X, Nowatzke, W, Ramanadham, S, Turk, J	J Biol Chem	1999

Participants

Input

Output

Participant Of

hasEvent

Acyl chain remodeling of CL

Catalyst Activity

Title

phospholipase A2 activity of PLA2G6 [mitochondrial inner membrane]

Physical Entity

PLA2G6 [mitochondrial inner membrane]

Activity

phospholipase A2 activity (0004623)

Inferred From

CL is hydrolyzed to MLCL by Pla2g6 (IM) (Rattus norvegicus)

Authored

Williams, MG (2011-09-14)

Created

Williams, MG (2011-08-12)