CL is hydrolyzed to MLCL by Pla2g6 (IM)

Stable Identifier
R-RNO-1482836
Type
Reaction [transition]
Species
Rattus norvegicus
Compartment
mitochondrial inner membrane, mitochondrial matrix
ReviewStatus
5/5
General
SVG | 
PNG
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Medium
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 | PPTX  | SBGN
CL is hydrolyzed to MLCL by Pla2g6 (IM)
In rats at the inner mitochondrial membrane (IM), calcium-independent phospholipase A2 gamma (Pla2g6) hydrolyzes, removing one of the acyl chains, cardiolipin (CL) to form monolysocardiolipin (MLCL) (Zachman et al. 2010).
Literature References
PubMed ID Title Journal Year
19741254 The role of calcium-independent phospholipase A2 in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

Zachman, DK, Chicco, AJ, McCune, SA, Murphy, RC, Moore, RL, Sparagna, GC

J Lipid Res 2010
Participants
Input
Output
Catalyst Activity

A2-type glycerophospholipase activity of Pla2g6 [mitochondrial inner membrane]

Physical Entity
Pla2g6 [mitochondrial inner membrane] (Rattus norvegicus)
Activity
A2-type glycerophospholipase activity (GO:0004623)
Orthologous Events
CL is hydrolyzed to MLCL by PLA2G6 (IM) (Homo sapiens)
Authored
Williams, MG  (2011-09-14)
Created
Williams, MG  (2011-08-12)
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