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PalmC-F3 [plasma membrane]
Stable Identifier
R-HSA-140704
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
tissue factor
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Formation of Fibrin Clot (Clotting Cascade) (Homo sapiens)
Extrinsic Pathway of Fibrin Clot Formation (Homo sapiens)
TFPI + TF:F7a + factor Xa -> TFPI:TF:F7a:factor Xa (Homo sapiens)
TF:F7a [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
TFPI:TF:F7a:factor Xa [plasma membrane] (Homo sapiens)
TF:F7a [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst) (Homo sapiens)
TF:F7a [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst) (Homo sapiens)
TF:F7 [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst) (Homo sapiens)
TF:F7a [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
sequestered tissue factor -> tissue factor (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
TF:F7a [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
tissue factor (TF) + factor VII (F7) -> TF:F7 complex (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
TF:F7 [plasma membrane] (Homo sapiens)
PalmC-F3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13726 F3
Gene Names
F3
Chain
signal peptide:1-32, chain:33-295
Reference Genes
BioGPS Gene:2152 F3
COSMIC (genes):F3 F3
CTD Gene:2152 F3
dbSNP Gene:2152 F3
ENSEMBL:ENSG00000117525 TF
HGNC:3541 F3
KEGG Gene (Homo sapiens):2152 F3
Monarch:2152 F3
NCBI Gene:2152 F3
OMIM:134390 F3
UCSC:P13726 F3
Reference Transcript
RefSeq:NM_001993.4 F3
RefSeq:NM_001178096.1 F3
Other Identifiers
11721290_a_at
11721291_a_at
11755733_a_at
16689869
204363_at
2152
2423910
2423911
2423912
2423913
2423914
2423915
2423916
2423918
2423920
2423922
2423923
2423924
2423928
2423933
2423934
2423935
36543_at
7917875
A_23_P126782
A_33_P3226832
GE475336
GE57466
GO:0001938
GO:0002020
GO:0002541
GO:0002543
GO:0003674
GO:0004252
GO:0004896
GO:0005515
GO:0005543
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0006919
GO:0006950
GO:0007165
GO:0007596
GO:0007598
GO:0007599
GO:0008150
GO:0008219
GO:0008233
GO:0008283
GO:0008289
GO:0009986
GO:0010628
GO:0010641
GO:0016020
GO:0016021
GO:0016485
GO:0019221
GO:0019899
GO:0030335
GO:0031012
GO:0031233
GO:0032757
GO:0032991
GO:0040011
GO:0043167
GO:0045766
GO:0048646
GO:0048856
GO:0048870
GO:0050927
GO:0051604
GO:0051897
GO:0062023
GO:1905286
ILMN_1797009
M27436_s_at
PH_hs_0003939
TC01002886.hg
g10518499_3p_at
Participant Of
input
tissue factor (TF) + activated factor VII (F7a) -> TF:F7a complex
tissue factor (TF) + factor VII (F7) -> TF:F7 complex
hasComponent
TF:F7 [plasma membrane]
TF:F7a [plasma membrane]
output
sequestered tissue factor -> tissue factor
Other forms of this molecule
sequestered tissue factor [plasma membrane]
Inferred To
PalmC-F3 [plasma membrane] (Gallus gallus)
PalmC-F3 [plasma membrane] (Xenopus tropicalis)
F3 [plasma membrane] (Bos taurus)
F3 [plasma membrane] (Mus musculus)
F3 [plasma membrane] (Rattus norvegicus)
F3 [plasma membrane] (Sus scrofa)
f3a [plasma membrane] (Danio rerio)
TF [plasma membrane] (Canis familiaris)
Modified Residues
Name
S-palmitoyl-L-cysteine at 277
Coordinate
277
PsiMod Name
S-palmitoyl-L-cysteine [MOD:00115]
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.
Cross References
RefSeq
NP_001171567.1
,
NP_001984.1
ZINC - Investigational
TF_HUMAN
OpenTargets
ENSG00000117525
HPA
ENSG00000117525-F3
ZINC - Substances
TF_HUMAN
GeneCards
P13726
Ensembl
ENST00000334047
,
ENSG00000117525
,
ENST00000370207
,
ENSP00000359226
,
ENSP00000334145
ZINC - Biogenic
TF_HUMAN
ZINC target
P13726
PRO
P13726
ZINC - Predictions - Purchasable
TF_HUMAN
PDB
2CEZ
,
2C4F
,
2AER
,
1WSS
,
2PUQ
,
1W2K
,
4Z6A
,
3ELA
,
2AEI
,
1TFH
,
1AHW
,
1WTG
,
2CEH
,
1NL8
,
2ZZU
,
2FLB
,
2B7D
,
2CFJ
,
2HFT
,
5W06
,
4IBL
,
1JPS
,
1O5D
,
6R2W
,
2CEF
,
2ZWL
,
2ZP0
,
1FAK
,
4ZMA
,
3TH2
,
4M7L
,
1WQV
,
2FLR
,
2B8O
,
3TH3
,
1DAN
,
2F9B
,
2A2Q
,
2EC9
,
1UJ3
,
1W0Y
,
1J9C
,
4YLQ
,
1WUN
,
3TH4
,
1BOY
,
2FIR
,
1WV7
,
1Z6J
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08709 F7
11
factor VII [Golgi lumen]
(R-HSA-159808)
factor VII propeptide [Golgi lumen]
(R-HSA-159847)
pro-factor VII [Golgi lumen]
(R-HSA-159767)
10xCbxE-F7(21-466) [endoplasmic reticulum lumen]
(R-HSA-159722)
F7(21-466) [endoplasmic reticulum lumen]
(R-HSA-159848)
10xCbxE-F7(61-466) [plasma membrane]
(R-HSA-140774)
10xCbxE-F7(61-466) [extracellular region]
(R-HSA-140771)
10xCbxE-F7(61-212) [extracellular region]
(R-HSA-140749)
factor VIIa heavy chain [extracellular region]
(R-HSA-140750)
10xCbxE-F7(61-212) [plasma membrane]
(R-HSA-140715)
factor VIIa heavy chain [plasma membrane]
(R-HSA-140724)
0.886
7
UniProt:Q9UM19 HPCL4
0.556
3
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