Reactome | PalmC-F3 [plasma membrane]

PalmC-F3 [plasma membrane]

Stable Identifier

R-HSA-140704

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

tissue factor

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P13726 F3

Gene Names

Chain

signal peptide:1-32, chain:33-295

Reference Genes

BioGPS Gene:2152 F3

COSMIC (genes):F3 F3

CTD Gene:2152 F3

dbSNP Gene:2152 F3

ENSEMBL:ENSG00000117525 TF

HGNC:3541 F3

KEGG Gene (Homo sapiens):2152 F3

Monarch:2152 F3

NCBI Gene:2152 F3

OMIM:134390 F3

UCSC:P13726 F3

Reference Transcript

Other Identifiers

11721290_a_at

11721291_a_at

11755733_a_at

16689869

204363_at

2152

2423910

2423911

2423912

2423913

2423914

2423915

2423916

2423918

2423920

2423922

2423923

2423924

2423928

2423933

2423934

2423935

36543_at

7917875

A_23_P126782

A_33_P3226832

GE475336

GE57466

GO:0001938

GO:0002020

GO:0002541

GO:0002543

GO:0003674

GO:0004252

GO:0004896

GO:0005515

GO:0005543

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0006919

GO:0006950

GO:0007165

GO:0007596

GO:0007598

GO:0007599

GO:0008150

GO:0008233

GO:0008283

GO:0008289

GO:0009986

GO:0010628

GO:0010641

GO:0016020

GO:0016021

GO:0016485

GO:0019221

GO:0019899

GO:0030335

GO:0031012

GO:0031233

GO:0032757

GO:0032991

GO:0040011

GO:0043167

GO:0045766

GO:0048646

GO:0048856

GO:0048870

GO:0050927

GO:0051604

GO:0051897

GO:0062023

GO:1905286

GO:2000264

HMNXSV003048205

ILMN_1797009

M27436_s_at

PH_hs_0003939

TC01002886.hg

g10518499_3p_at

Participates

as an output of

sequestered tissue factor -> tissue factor (Homo sapiens)

as an input of

as a component of

Other forms of this molecule

sequestered tissue factor [plasma membrane]

Inferred To

PalmC-F3 [plasma membrane] (Gallus gallus)

F3 [plasma membrane] (Bos taurus)

F3 [plasma membrane] (Canis familiaris)

F3 [plasma membrane] (Mus musculus)

F3 [plasma membrane] (Rattus norvegicus)

F3 [plasma membrane] (Sus scrofa)

f3a [plasma membrane] (Danio rerio)

f3 [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

S-palmitoyl-L-cysteine at 277

Coordinate

277

PsiMod Name

S-palmitoyl-L-cysteine [MOD:00115]

PsiMod Definition

A protein modification that effectively converts an L-cysteine residue to S-palmitoyl-L-cysteine.

Cross References

RefSeq

NP_001984.1, NP_001171567.1

OpenTargets

ENSG00000117525

ZINC - Substances

TF_HUMAN

ZINC - Biogenic

TF_HUMAN

ZINC target

P13726

PRO

P13726

GlyGen

P13726

PDB

6R2W, 2CFJ, 2F9B, 1WTG, 2HFT, 2FIR, 1WQV, 2CEZ, 2B8O, 4M7L, 1FAK, 1W0Y, 4Z6A, 2FLR, 1J9C, 1AHW, 3ELA, 2CEH, 2FLB, 2PUQ, 1O5D, 1JPS, 1DAN, 1UJ3, 2A2Q, 5W06, 1NL8, 2CEF, 3TH4, 2B7D, 1WV7, 1Z6J, 2C4F, 1WSS, 2AER, 3TH3, 4IBL, 4ZMA, 3TH2, 1WUN, 2ZP0, 2AEI, 1W2K, 2ZWL, 2EC9, 1TFH, 1BOY, 2ZZU, 4YLQ

ZINC - Investigational

TF_HUMAN

HPA

ENSG00000117525-F3

GeneCards

P13726

Ensembl

ENSP00000359226, ENSP00000334145, ENST00000370207, ENST00000334047, ENSG00000117525

Pharos - Targets

P13726

Orphanet

29631

ZINC - Predictions - Purchasable

TF_HUMAN

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08709 F7	11	10xCbxE-F7(61-212) [extracellular region] (R-HSA-140749) pro-factor VII [Golgi lumen] (R-HSA-159767) 10xCbxE-F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159722) F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159848) factor VII [Golgi lumen] (R-HSA-159808) factor VIIa heavy chain [extracellular region] (R-HSA-140750) factor VIIa heavy chain [plasma membrane] (R-HSA-140724) factor VII propeptide [Golgi lumen] (R-HSA-159847) 10xCbxE-F7(61-212) [plasma membrane] (R-HSA-140715) 10xCbxE-F7(61-466) [plasma membrane] (R-HSA-140774) 10xCbxE-F7(61-466) [extracellular region] (R-HSA-140771)	0.881	7
UniProt:Q9UM19 HPCL4			0.556	3

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