Reactome | pro-factor VII [Golgi lumen]

pro-factor VII [Golgi lumen]

Stable Identifier

R-HSA-159767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

9xCbxE-F7(21-466)

Locations in the PathwayBrowser

Expand all

Literature References

PubMed ID	Title	Journal	Year
3264725	Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells Thim, L, Bjoern, S, Christensen, M, Nicolaisen, EM, Lund-Hansen, T, Pedersen, AH, Hedner, U	Biochemistry	1988
3486420	Characterization of a cDNA coding for human factor VII Hagen, FS, Gray, CL, O'Hara, P, Grant, FJ, Saari, GC, Woodbury, RG, Hart, CE, Insley, M, Kisiel, W, Kurachi, K	Proc Natl Acad Sci U S A	1986

External Reference Information

External Reference

UniProt:P08709 F7

Gene Names

Chain

signal peptide:1-20, propeptide:21-60, chain:61-212, chain:213-466

Reference Genes

BioGPS Gene:2155 F7

COSMIC (genes):F7 F7

CTD Gene:2155 F7

dbSNP Gene:2155 F7

ENSEMBL:ENSG00000057593 F7

HGNC:3544 F7

KEGG Gene (Homo sapiens):2155 F7

Monarch:2155 F7

NCBI Gene:2155 F7

OMIM:613878 F7

UCSC:P08709 F7

Reference Transcript

Other Identifiers

0001580685

0002360402

11732883_a_at

11732884_a_at

11741968_a_at

16776784

207300_s_at

2155

237414_at

33520_at

3502412

3502413

3502414

3502418

3502421

3502422

3502423

3502424

3502427

3502431

3502432

3502433

3502434

3502435

3502436

46361_at

7970232

A_23_P117298

A_24_P172738

GE57818

GO:0001666

GO:0002376

GO:0002690

GO:0003674

GO:0004175

GO:0004252

GO:0005102

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0006508

GO:0006810

GO:0006888

GO:0006950

GO:0007165

GO:0007596

GO:0007598

GO:0007599

GO:0007623

GO:0008150

GO:0008233

GO:0008236

GO:0009725

GO:0010037

GO:0010641

GO:0014070

GO:0016192

GO:0016485

GO:0016787

GO:0030194

GO:0030335

GO:0031012

GO:0031100

GO:0031667

GO:0031982

GO:0032355

GO:0032571

GO:0032991

GO:0033595

GO:0040011

GO:0043167

GO:0043226

GO:0043627

GO:0048856

GO:0048870

GO:0050927

GO:0051604

GO:0051897

GO:0060416

GO:0061476

GO:0062023

GO:0070723

GO:0097066

GO:0097068

GO:1904400

GO:1904612

GO:1905217

GO:1905225

GO:1905286

Hs.39156.0.A1_3p_at

ILMN_1740559

ILMN_2267025

ILMN_2358265

M13232_s_at

PH_hs_0002924

TC13000416.hg

g10518501_3p_a_at

Participant Of

input

Furin cleaves pro-factor VII to factor VII

output

Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus

Other forms of this molecule

factor VII propeptide [Golgi lumen]

factor VII [Golgi lumen]

10xCbxE-F7(21-466) [endoplasmic reticulum lumen]

F7(21-466) [endoplasmic reticulum lumen]

10xCbxE-F7(61-466) [plasma membrane]

10xCbxE-F7(61-466) [extracellular region]

10xCbxE-F7(61-212) [extracellular region]

factor VIIa heavy chain [extracellular region]

10xCbxE-F7(61-212) [plasma membrane]

factor VIIa heavy chain [plasma membrane]

Inferred To

F7 [Golgi lumen] (Bos taurus)

F7 [Golgi lumen] (Mus musculus)

F7 [Golgi lumen] (Rattus norvegicus)

F7 [Golgi lumen] (Sus scrofa)

pro-factor VII [Golgi lumen] (Gallus gallus)

f7 [Golgi lumen] (Danio rerio)

f7 [Golgi lumen] (Xenopus tropicalis)

F10 [Golgi lumen] (Canis familiaris)

HDC06756 [Golgi lumen] (Drosophila melanogaster)

Modified Residues

Name

L-gamma-carboxyglutamic acid at 95

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 89

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 86

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 85

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 80

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 79

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 76

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 74

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 67

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Cross References

RefSeq

NP_000122.1, NP_062562.1

OpenTargets

ENSG00000057593

ZINC - Substances

FA7_HUMAN

ZINC target

P08709

PRO

P08709

PDB

1FFM, 1WUN, 4ISH, 4ZXY, 4NGA, 1WQV, 5PAF, 1CVW, 4ZMA, 2FLB, 5TQE, 5PAU, 2B7D, 4NG9, 5PAB, 4ISI, 2ZZU, 4ZXX, 4YT6, 2ZWL, 3TH2, 2ZP0, 4X8T, 5PAT, 1JBU, 1W8B, 1O5D, 4JYU, 5PB0, 1QFK, 5PAG, 4JYV, 1W0Y, 5PAW, 2B8O, 1WSS, 5PB5, 5PAO, 5L2Y, 2F9B, 1F7M, 1NL8, 4JZF, 5PB4, 5PB2, 5PAJ, 4X8V, 1YGC, 5PAR, 4IBL, 3TH4, 5PA8, 4X8S, 5L2Z, 5PA9, 5TQG, 5PAE, 5L0S, 2AEI, 5U6J, 1W7X, 1Z6J, 1WV7, 4Z6A, 1KLI, 2AER, 5PAC, 5TQF, 5PAV, 5PAS, 2FLR, 1KLJ, 4JZD, 5PAM, 2EC9, 2A2Q, 5PAI, 5PAY, 5I46, 1BF9, 4YLQ, 2FIR, 4YT7, 5PB6, 5PAX, 5PB3, 2PUQ, 1WTG, 1FAK, 2C4F, 4JZE, 1F7E, 4NA9, 5PAN, 2BZ6, 4X8U, 5PB1, 3ELA, 5PAK, 5PAA, 1FF7, 1W2K, 5L30, 3TH3, 5PAQ, 1DAN, 1DVA, 1J9C

ZINC - Investigational

FA7_HUMAN

GeneCards

P08709

HPA

ENSG00000057593-F7

Ensembl

ENST00000375581, ENSP00000329546, ENSP00000364731, ENSG00000057593, ENST00000346342

ZINC - Predictions - Purchasable

FA7_HUMAN

Orphanet

16015

HMDB Protein

HMDBP02013

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13726 F3	2	sequestered tissue factor [plasma membrane] (R-HSA-140762) PalmC-F3 [plasma membrane] (R-HSA-140704)	0.886	7
UniProt:P08709 F7	11	factor VII [Golgi lumen] (R-HSA-159808) factor VII propeptide [Golgi lumen] (R-HSA-159847) pro-factor VII [Golgi lumen] (R-HSA-159767) 10xCbxE-F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159722) F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159848) 10xCbxE-F7(61-466) [plasma membrane] (R-HSA-140774) 10xCbxE-F7(61-466) [extracellular region] (R-HSA-140771) 10xCbxE-F7(61-212) [extracellular region] (R-HSA-140749) factor VIIa heavy chain [extracellular region] (R-HSA-140750) 10xCbxE-F7(61-212) [plasma membrane] (R-HSA-140715) factor VIIa heavy chain [plasma membrane] (R-HSA-140724)	0.589	2