Reactome | pro-factor VII [Golgi lumen]

pro-factor VII [Golgi lumen]

Stable Identifier

R-HSA-159767

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi lumen

Synonyms

9xCbxE-F7(21-466)

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
3264725	Amino acid sequence and posttranslational modifications of human factor VIIa from plasma and transfected baby hamster kidney cells Thim, L, Bjoern, S, Christensen, M, Nicolaisen, EM, Lund-Hansen, T, Pedersen, AH, Hedner, U	Biochemistry	1988
3486420	Characterization of a cDNA coding for human factor VII Hagen, FS, Gray, CL, O'Hara, P, Grant, FJ, Saari, GC, Woodbury, RG, Hart, CE, Insley, M, Kisiel, W, Kurachi, K	Proc Natl Acad Sci U S A	1986

External Reference Information

External Reference

UniProt:P08709 F7

Gene Names

Chain

signal peptide:1-20, propeptide:21-60, chain:61-212, chain:213-466

Reference Genes

BioGPS Gene:2155 F7

COSMIC (genes):F7 F7

CTD Gene:2155 F7

dbSNP Gene:2155 F7

ENSEMBL:ENSG00000057593 F7

HGNC:3544 F7

KEGG Gene (Homo sapiens):2155 F7

Monarch:2155 F7

NCBI Gene:2155 F7

OMIM:613878 F7

UCSC:P08709 F7

Reference Transcript

Other Identifiers

0001580685

0002360402

11732883_a_at

11732884_a_at

11741968_a_at

16776784

1BF9

1CVW

1DAN

1DVA

1F7E

1F7M

1FAK

1FF7

1FFM

1J9C

1JBU

1KLI

1KLJ

1NL8

1O5D

1QFK

1W0Y

1W2K

1W7X

1W8B

1WQV

1WSS

1WTG

1WUN

1WV7

1YGC

1Z6J

207300_s_at

2155

237414_at

2A2Q

2AEI

2AER

2B7D

2B8O

2BZ6

2C4F

2EC9

2F9B

2FIR

2FLB

2FLR

2PUQ

2ZP0

2ZWL

2ZZU

33520_at

3502412

3502413

3502414

3502418

3502421

3502422

3502423

3502424

3502427

3502431

3502432

3502433

3502434

3502435

3502436

3ELA

3TH2

3TH3

3TH4

46361_at

4826

4IBL

4ISH

4ISI

4JYU

4JYV

4JZD

4JZE

4JZF

4NA9

4NG9

4NGA

4X8S

4X8T

4X8U

4X8V

4YLQ

4YT6

4YT7

4Z6A

4ZMA

4ZXX

4ZXY

5I46

5L0S

5L2Y

5L2Z

5L30

5PA8

5PA9

5PAA

5PAB

5PAC

5PAE

5PAF

5PAG

5PAI

5PAJ

5PAK

5PAM

5PAN

5PAO

5PAQ

5PAR

5PAS

5PAT

5PAU

5PAV

5PAW

5PAX

5PAY

5PB0

5PB1

5PB2

5PB3

5PB4

5PB5

5PB6

5TQE

5TQF

5TQG

5U6J

7970232

A_23_P117298

A_24_P172738

AAA51983

AAA88040

AAA88041

AAI30469

AAL66184

AAP33841

ABD17891

ACA06107

ACA06108

ACB87203

AF466933

AL137002

AY212252

BC130468

CCDS9528

CCDS9529

DQ142911

E9PH36

EF445049

ENSG00000057593

ENSP00000329546

ENSP00000364731

ENST00000346342

ENST00000346342.7

ENST00000375581

ENST00000375581.3

EntrezGene:2155

EntrezGene:F7

EU557239

F5H8B0

F7-201

F7-202

g10518501_3p_a_at

GE57818

GO:0001666

GO:0002376

GO:0002690

GO:0003674

GO:0004175

GO:0004252

GO:0005102

GO:0005509

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005783

GO:0005788

GO:0005794

GO:0005796

GO:0005886

GO:0006508

GO:0006810

GO:0006888

GO:0006950

GO:0007165

GO:0007596

GO:0007598

GO:0007599

GO:0007623

GO:0008150

GO:0008233

GO:0008236

GO:0009725

GO:0010037

GO:0010641

GO:0014070

GO:0016192

GO:0016485

GO:0016787

GO:0030194

GO:0030335

GO:0031012

GO:0031100

GO:0031667

GO:0031982

GO:0032355

GO:0032571

GO:0032991

GO:0033595

GO:0040011

GO:0043167

GO:0043226

GO:0043627

GO:0048856

GO:0048870

GO:0050927

GO:0051604

GO:0051897

GO:0060416

GO:0061476

GO:0062023

GO:0070723

GO:0097066

GO:0097068

GO:1904400

GO:1904612

GO:1905217

GO:1905225

GO:1905286

HGNC:3544

HPA004826

Hs.39156.0.A1_3p_at

ILMN_1740559

ILMN_2267025

ILMN_2358265

IPR000152

IPR000294

IPR000742

IPR001254

IPR001314

IPR001881

IPR009003

IPR012224

IPR013032

IPR017857

IPR018097

IPR018114

IPR033116

IPR033190

IPR035972

J02933

LRG_554

LRG_554t1

LRG_554t2

M13232

M13232_s_at

MIM:227500

MIM:608446

MIM:613878

NM_000131

NM_019616

NP_000122

NP_062562

PF00008

PF00089

PF00594

PH_hs_0002924

PR00001

PR00010

PR00722

SM00020

SM00069

SM00179

SM00181

TC13000416.hg

UPI000002A952

UPI000012A414

XM_006719963

XM_011537474

XP_006720026

XP_011535776

Participant Of

input

Furin cleaves pro-factor VII to factor VII

output

Gamma-carboxy pro-factor VII transport from the endoplasmic reticulum to the Golgi apparatus

Other forms of this molecule

factor VII propeptide [Golgi lumen]

factor VII [Golgi lumen]

10xCbxE-F7(21-466) [endoplasmic reticulum lumen]

F7(21-466) [endoplasmic reticulum lumen]

10xCbxE-F7(61-466) [plasma membrane]

10xCbxE-F7(61-466) [extracellular region]

10xCbxE-F7(61-212) [extracellular region]

factor VIIa heavy chain [extracellular region]

10xCbxE-F7(61-212) [plasma membrane]

factor VIIa heavy chain [plasma membrane]

Inferred To

pro-factor VII [Golgi lumen] (Bos taurus)

pro-factor VII [Golgi lumen] (Canis familiaris)

pro-factor VII [Golgi lumen] (Danio rerio)

pro-factor VII [Golgi lumen] (Drosophila melanogaster)

pro-factor VII [Golgi lumen] (Gallus gallus)

pro-factor VII [Golgi lumen] (Mus musculus)

pro-factor VII [Golgi lumen] (Rattus norvegicus)

pro-factor VII [Golgi lumen] (Sus scrofa)

pro-factor VII [Golgi lumen] (Xenopus tropicalis)

Homologues of pro-factor VII [Golgi lumen] (Drosophila melanogaster)

Modified Residues

Name

L-gamma-carboxyglutamic acid at 95

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 89

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 86

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 85

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 80

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 79

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 76

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 74

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Name

L-gamma-carboxyglutamic acid at 67

Coordinate

PsiMod Name

L-gamma-carboxyglutamic acid [MOD:00041]

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to L-gamma-carboxyglutamic acid.

Cross References

ZINC - Investigational

FA7_HUMAN

RefSeq

NP_062562.1, NP_000122.1

OpenTargets

ENSG00000057593

GeneCards

P08709

ZINC - Substances

FA7_HUMAN

ZINC target

P08709

PRO

P08709

Orphanet

16015

ZINC - Predictions - Purchasable

FA7_HUMAN

HMDB Protein

HMDBP02013

PDB

2F9B, 4JZD, 5PB0, 1WUN, 5PAF, 5PAW, 4Z6A, 4X8U, 5PB5, 2C4F, 5PAE, 5TQG, 5U6J, 4JYU, 1NL8, 5PAA, 2EC9, 5L0S, 5PAV, 4NG9, 5TQF, 5PB4, 1YGC, 1WQV, 2ZWL, 2B8O, 5PAS, 5PA9, 4ZXY, 2ZZU, 4X8S, 2A2Q, 5L30, 1CVW, 5PAR, 4ISI, 1FF7, 5PAN, 2FLR, 5L2Y, 1KLI, 3TH4, 2ZP0, 4NA9, 1WSS, 4IBL, 5PAM, 4YT6, 1J9C, 1W7X, 5PAI, 1FFM, 1FAK, 4JZE, 5PB2, 1W0Y, 5PAY, 3TH2, 4NGA, 2B7D, 5PAG, 4X8V, 1WV7, 5PAC, 4JYV, 2AEI, 2FIR, 5PAX, 5PB6, 1F7E, 5PAU, 1BF9, 1JBU, 5PB3, 5I46, 5PAB, 5TQE, 4X8T, 1KLJ, 1O5D, 5PAT, 5PA8, 1W2K, 2FLB, 1DAN, 2PUQ, 5PAQ, 5L2Z, 4YLQ, 4ZXX, 3ELA, 4ZMA, 1DVA, 5PAO, 1WTG, 4ISH, 2BZ6, 4YT7, 5PAK, 1QFK, 1Z6J, 4JZF, 1W8B, 5PAJ, 3TH3, 1F7M, 5PB1, 2AER

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13726 F3	2	PalmC-F3 [plasma membrane] (R-HSA-140704) sequestered tissue factor [plasma membrane] (R-HSA-140762)	0.886	7
UniProt:P08709 F7	11	factor VII [Golgi lumen] (R-HSA-159808) factor VII propeptide [Golgi lumen] (R-HSA-159847) pro-factor VII [Golgi lumen] (R-HSA-159767) 10xCbxE-F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159722) F7(21-466) [endoplasmic reticulum lumen] (R-HSA-159848) 10xCbxE-F7(61-466) [plasma membrane] (R-HSA-140774) 10xCbxE-F7(61-466) [extracellular region] (R-HSA-140771) 10xCbxE-F7(61-212) [extracellular region] (R-HSA-140749) factor VIIa heavy chain [extracellular region] (R-HSA-140750) 10xCbxE-F7(61-212) [plasma membrane] (R-HSA-140715) factor VIIa heavy chain [plasma membrane] (R-HSA-140724)	0.589	2