Elevation of cytosolic Ca2+ levels

Stable Identifier
R-HSA-139853
Type
Pathway
Species
Homo sapiens
Compartment
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Activation of non- excitable cells involves the agonist-induced elevation of cytosolic Ca2+, an essential process for platelet activation. It occurs through Ca2+ release from intracellular stores and Ca2+ entry through the plasma membrane. Ca2+ store release involves phospholipase C (PLC)-mediated production of inositol-1,4,5-trisphosphate (IP3), which in turn stimulates IP3 receptor channels to release Ca2+ from intracellular stores. This is followed by Ca2+ entry into the cell through plasma membrane calcium channels, a process referred to as store-operated calcium entry (SOCE). Stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and the four transmembrane channel protein Orai1 are the key players in platelet SOCE. Other major Ca2+ entry mechanisms are mediated by the direct receptor-operated calcium (ROC) channel, P2X1 and transient receptor potential channels (TRPCs).

Literature References
PubMed ID Title Journal Year
17703229 Calcium signalling in lymphocyte activation and disease

Feske, S

Nat Rev Immunol 2007
19422456 Calcium signaling in platelets

Varga-Szabo, D, Braun, A, Nieswandt, B

J Thromb Haemost 2009
18308196 Intracellular calcium release from human platelets: different messengers for multiple stores

Jardin, I, López, JJ, Rosado, JA, Salido, GM, Pariente, JA

Trends Cardiovasc Med 2008
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Orthologous Events
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BioModels Database
GlyCosmos
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