STIM1 activation of CRAC

Stable Identifier
R-HSA-434700
Type
Reaction
Species
Homo sapiens
Compartment
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Sustained calcium signalling in lymphocytes and platelets requires the uptake of extracellular calcium when intracellular stores are depleted. The process whereby intracellular calcium depletion stimulates calcium uptake is often referred to as Store-operated calcium entry (SOCE). Store depletion is sensed by stromal interaction molecule 1 (STIM1), which then translocates to the plasma membrane and associates with 2 dimers of Orai to form a calcium-release activated calcium (CRAC) channel.

Literature References
PubMed ID Title Journal Year
17452328 Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels

Smyth, JT, Putney, JW, Boyles, RR, DeHaven, WI

J. Biol. Chem. 2007
18187424 Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation

Gruber, H, Frischauf, I, Romanin, C, Derler, I, Fahrner, M, Madl, J, Schindl, R, Eder, P, Polzinger, B, Hesch, C, Kahr, H, Muik, M, Fritsch, R, Bergsmann, J, Groschner, K

J Biol Chem 2008
19249086 STIM1 clusters and activates CRAC channels via direct binding of a cytosolic domain to Orai1

Bachhawat, P, Dolmetsch, RE, Hoover, PJ, Raunser, S, Park, CY, Covington, ED, Garcia, KC, Lewis, RS, Mullins, FM, Walz, T

Cell 2009
18596693 Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

Prakriya, M, Wu, MM, Wang, B, Lewis, RS, Luik, RM

Nature 2008
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