Cation influx mediated by TRPC3/6/7

Stable Identifier
R-HSA-426223
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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TRP channels are non-selectively permeable to cations, allowing enty into the cell via concentration gradients. All mammalian TRPCs require PLC for activation.

Literature References
PubMed ID Title Journal Year
11805119 Cloning and functional expression of human short TRP7, a candidate protein for store-operated Ca2+ influx

Riccio, A, Mattei, C, Kelsell, RE, Medhurst, AD, Calver, AR, Randall, AD, Davis, JB, Benham, CD, Pangalos, MN

J Biol Chem 2002
8646775 trp, a novel mammalian gene family essential for agonist-activated capacitative Ca2+ entry

Zhu, X, Jiang, M, Peyton, M, Boulay, G, Hurst, R, Stefani, E, Birnbaumer, L

Cell 1996
9930701 Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol

Hofmann, T, Obukhov, AG, Schaefer, M, Harteneck, C, Gudermann, T, Schultz, G

Nature 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cation channel activity of DAG-activated TRPC3/6/7 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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