betaKlotho-mediated ligand binding

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R-HSA-1307965
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Pathway
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Homo sapiens
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FGF21 and FGF19 require betaKlotho for efficient signaling through FGFR1c and FGFR3c. betaKlotho does not interact with 'b' receptor isoforms, and only weakly with FGFR2c. In addition, FGF19, but not FGF21, signals through FGFR4 in a betaKlotho-dependent fashion

Literature References
PubMed ID Title Journal Year
17623664 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Kurosu, H, Choi, M, Ogawa, Y, Dickson, AS, Goetz, R, Eliseenkova, AV, Mohammadi, M, Rosenblatt, KP, Kliewer, SA, Kuro-O, M

J Biol Chem 2007
19063940 The Klotho gene family as a regulator of endocrine fibroblast growth factors

Kurosu, H, Kuro-O, M

Mol Cell Endocrinol 2009
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