betaKlotho-mediated ligand binding

Stable Identifier
R-HSA-1307965
Type
Pathway
Species
Homo sapiens
Compartment
cytosol, extracellular region, plasma membrane
ReviewStatus
5/5
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betaKlotho-mediated ligand binding
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FGF21 and FGF19 require betaKlotho for efficient signaling through FGFR1c and FGFR3c. betaKlotho does not interact with 'b' receptor isoforms, and only weakly with FGFR2c. In addition, FGF19, but not FGF21, signals through FGFR4 in a betaKlotho-dependent fashion
Literature References
PubMed ID Title Journal Year
19063940 The Klotho gene family as a regulator of endocrine fibroblast growth factors

Kuro-O, M, Kurosu, H

Mol Cell Endocrinol 2009
17623664 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Kuro-O, M, Eliseenkova, AV, Goetz, R, Kliewer, SA, Ogawa, Y, Dickson, AS, Kurosu, H, Mohammadi, M, Choi, M, Rosenblatt, KP

J Biol Chem 2007
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Authored
Rothfels, K  (2011-08-15)
Reviewed
Gotoh, N  (2011-08-26)
Created
Rothfels, K  (2011-05-30)
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