FGFR4 binds HS:KLB:FGF19

Stable Identifier
R-HSA-1307955
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
FGFR4 binds BetaKlotho-bound FGF19
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BetaKlotho (KLB) and heparan sulfate (HS) are required for fibroblast growth factor 19 (FGF19)-dependent signaling through fibroblast growth factor receptor 4 (FGFR4) .

Literature References
PubMed ID Title Journal Year
17623664 Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21

Kurosu, H, Choi, M, Ogawa, Y, Dickson, AS, Goetz, R, Eliseenkova, AV, Mohammadi, M, Rosenblatt, KP, Kliewer, SA, Kuro-O, M

J Biol Chem 2007
19063940 The Klotho gene family as a regulator of endocrine fibroblast growth factors

Kurosu, H, Kuro-O, M

Mol Cell Endocrinol 2009
20080590 Relevant use of Klotho in FGF19 subfamily signaling system in vivo

Tomiyama, K, Maeda, R, Urakawa, I, Yamazaki, Y, Tanaka, T, Ito, S, Nabeshima, Y, Tomita, T, Odori, S, Hosoda, K, Nakao, K, Imura, A, Nabeshima, Y

Proc Natl Acad Sci U S A 2010
17339340 Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members

Goetz, R, Beenken, A, Ibrahimi, OA, Kalinina, J, Olsen, SK, Eliseenkova, AV, Xu, C, Neubert, TA, Zhang, F, Linhardt, RJ, Yu, X, White, KE, Inagaki, T, Kliewer, SA, Yamamoto, M, Kurosu, H, Ogawa, Y, Kuro-O, M, Lanske, B, Razzaque, MS, Mohammadi, M

Mol Cell Biol 2007
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