Reactome | Ca2+ activated K+ channels

Ca2+ activated K+ channels

Stable Identifier

R-HSA-1296052

Type

Pathway

Species

Homo sapiens

Compartment

cytosol, extracellular region, plasma membrane

Synonyms

Ca activated K+ channels

ReviewStatus

5/5

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Ca2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the Ca2+ ion concentration increased, The efflux of K+ via these channels leads to repolarization/hyperpolarization of the membrane potential which limits the Ca2+ influx though voltage activated Ca2+ channels (VGCC) thereby regulating the influx of Ca2+ flow via VGCC.

Literature References

PubMed ID	Title	Journal	Year
19074509	Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation Sheng, JZ, Ella, S, Davis, MJ, Hill, MA, Braun, AP	FASEB J	2009
20178789	Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling Hill, MA, Yang, Y, Ella, SR, Davis, MJ, Braun, AP	FEBS Lett	2010
20859064	Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel ?2-subunit in human and rodent pancreas Ohya, S, Fujimori, T, Kimura, T, Yamamura, H, Imaizumi, Y	J Pharmacol Sci	2010
19149539	The intermediate-conductance Ca2+ -activated K+ channel (KCa3.1) in vascular disease Tharp, DL, Bowles, DK	Cardiovasc Hematol Agents Med Chem	2009