Ca2+ activated K+ channels

Stable Identifier
R-HSA-1296052
Type
Pathway
Species
Homo sapiens
Compartment
Synonyms
Ca activated K+ channels
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Ca2+ activated potassium channels are expressed in neuronal and non-neuronal tissue such as smooth muscle, epithelial cell and sensory cells. Ca2+ activated potassium channels are activated when the Ca2+ ion concentration increased, The efflux of K+ via these channels leads to repolarization/hyperpolarization of the membrane potential which limits the Ca2+ influx though voltage activated Ca2+ channels (VGCC) thereby regulating the influx of Ca2+ flow via VGCC.

Literature References
PubMed ID Title Journal Year
19074509 Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

Hill, MA, Ella, S, Braun, AP, Sheng, JZ, Davis, MJ

FASEB J 2009
20178789 Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

Hill, MA, Ella, SR, Braun, AP, Yang, Y, Davis, MJ

FEBS Lett 2010
20859064 Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel ?2-subunit in human and rodent pancreas

Yamamura, H, Kimura, T, Ohya, S, Fujimori, T, Imaizumi, Y

J Pharmacol Sci 2010
19149539 The intermediate-conductance Ca2+ -activated K+ channel (KCa3.1) in vascular disease

Bowles, DK, Tharp, DL

Cardiovasc Hematol Agents Med Chem 2009
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