Increase in intracellular concentration of Ca2+ ions and membrane depolarization cooperatively activates BKca, which exhibit large unitary conductance. Ca2+ activated potassium channels. Activation leads to K+ efflux which changes the membrane potential, which leads to inactivation voltage activated Ca2+ channels. BKca are involved in regulation of smooth muscle tone, microbial killing in leukocytes and modulation of neurotransmitter release. Activation of BKca channel with increase in intracellular concentration of Ca2+ leads to efflux of K+ into the extracellular space, which contributes to hyperpolarization of the membrane potential.
Hill, MA, Ella, SR, Braun, AP, Yang, Y, Davis, MJ
Yamamura, H, Kimura, T, Ohya, S, Fujimori, T, Imaizumi, Y
potassium channel activity of BK channel [plasma membrane]
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