Activation of Ca2+ activated Potassium channels with large conductance

Stable Identifier
R-HSA-1296037
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of Ca2+ activated Potassium channels with large conductance
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Increase in intracellular concentration of Ca2+ ions and membrane depolarization cooperatively activates BKca, which exhibit large unitary conductance. Ca2+ activated potassium channels. Activation leads to K+ efflux which changes the membrane potential, which leads to inactivation voltage activated Ca2+ channels. BKca are involved in regulation of smooth muscle tone, microbial killing in leukocytes and modulation of neurotransmitter release. Activation of BKca channel with increase in intracellular concentration of Ca2+ leads to efflux of K+ into the extracellular space, which contributes to hyperpolarization of the membrane potential.
Literature References
PubMed ID Title Journal Year
20178789 Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

Hill, MA, Ella, SR, Braun, AP, Yang, Y, Davis, MJ

FEBS Lett 2010
20859064 Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel ?2-subunit in human and rodent pancreas

Yamamura, H, Kimura, T, Ohya, S, Fujimori, T, Imaizumi, Y

J Pharmacol Sci 2010
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activity of BK channel [plasma membrane]

Physical Entity
BK channel [plasma membrane] (Homo sapiens)
Activity
potassium channel activity (GO:0005267)
Orthologous Events
Activation of Ca2+ activated Potassium channels with large conductance (Bos taurus)
Activation of Ca2+ activated Potassium channels with large conductance (Canis familiaris)
Activation of Ca2+ activated Potassium channels with large conductance (Gallus gallus)
Activation of Ca2+ activated Potassium channels with large conductance (Mus musculus)
Activation of Ca2+ activated Potassium channels with large conductance (Rattus norvegicus)
Activation of Ca2+ activated Potassium channels with large conductance (Sus scrofa)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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