Activation of Ca2+ activated Potassium channels with large conductance

Stable Identifier
R-HSA-1296037
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Increase in intracellular concentration of Ca2+ ions and membrane depolarization cooperatively activates BKca, which exhibit large unitary conductance. Ca2+ activated potassium channels. Activation leads to K+ efflux which changes the membrane potential, which leads to inactivation voltage activated Ca2+ channels. BKca are involved in regulation of smooth muscle tone, microbial killing in leukocytes and modulation of neurotransmitter release. Activation of BKca channel with increase in intracellular concentration of Ca2+ leads to efflux of K+ into the extracellular space, which contributes to hyperpolarization of the membrane potential.

Literature References
PubMed ID Title Journal Year
20859064 Novel spliced variants of large-conductance Ca(2+)-activated K(+)-channel ?2-subunit in human and rodent pancreas

Ohya, S, Fujimori, T, Kimura, T, Yamamura, H, Imaizumi, Y

J Pharmacol Sci 2010
20178789 Large conductance, Ca2+-activated K+ channels (BKCa) and arteriolar myogenic signaling

Hill, MA, Yang, Y, Ella, SR, Davis, MJ, Braun, AP

FEBS Lett 2010
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
potassium channel activity of BK channel [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
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Created
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