Activation of Ca2+ activated Potassium channels with small conductance

Stable Identifier
R-HSA-1296039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
plasma membrane, cytosol, extracellular region
ReviewStatus
5/5
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Activation of Ca2+ activated Potassium channels with small conductance
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Small conductance Ca2+ activated potassium channels (SKca) are solely activated by intracellular Ca2+ concentration. SKca channels form functional tetramers. SKca channels control the contractility of uterus, maintian vascular tone, modulate hormone secretion, control cell volume in red blood cells and activation of microglia and lymphocytes. Actiavtion of SKca channels is triggered by increase in the intracellular Ca2+ ion concentration. Activation of Skca channels leads to relatively small K+ ion effluxes.

Literature References
PubMed ID Title Journal Year
19074509 Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

Hill, MA, Ella, S, Braun, AP, Sheng, JZ, Davis, MJ

FASEB J 2009
Participants
Input
Output
Participates
as an event of
Catalyst Activity

potassium channel activity of Small conductance Ca2+ activated potassium channel [plasma membrane]

Physical Entity
Small conductance Ca2+ activated potassium channel [plasma membrane] (Homo sapiens)
Activity
potassium channel activity (GO:0005267)
Orthologous Events
Activation of Ca2+ activated Potassium channels with small conductance (Bos taurus)
Activation of Ca2+ activated Potassium channels with small conductance (Caenorhabditis elegans)
Activation of Ca2+ activated Potassium channels with small conductance (Canis familiaris)
Activation of Ca2+ activated Potassium channels with small conductance (Danio rerio)
Activation of Ca2+ activated Potassium channels with small conductance (Dictyostelium discoideum)
Activation of Ca2+ activated Potassium channels with small conductance (Drosophila melanogaster)
Activation of Ca2+ activated Potassium channels with small conductance (Gallus gallus)
Activation of Ca2+ activated Potassium channels with small conductance (Mus musculus)
Activation of Ca2+ activated Potassium channels with small conductance (Rattus norvegicus)
Activation of Ca2+ activated Potassium channels with small conductance (Sus scrofa)
Activation of Ca2+ activated Potassium channels with small conductance (Xenopus tropicalis)
Cross References
Rhea
Authored
Mahajan, SS  (2011-05-19)
Reviewed
Jassal, B  (2010-09-23)
Created
Mahajan, SS  (2011-05-19)
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