Activation of Ca2+ activated Potassium channels with small conductance

Stable Identifier
R-HSA-1296039
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Small conductance Ca2+ activated potassium channels (SKca) are solely activated by intracellular Ca2+ concentration. SKca channels form functional tetramers. SKca channels control the contractility of uterus, maintian vascular tone, modulate hormone secretion, control cell volume in red blood cells and activation of microglia and lymphocytes. Actiavtion of SKca channels is triggered by increase in the intracellular Ca2+ ion concentration. Activation of Skca channels leads to relatively small K+ ion effluxes.

Literature References
PubMed ID Title Journal Year
19074509 Openers of SKCa and IKCa channels enhance agonist-evoked endothelial nitric oxide synthesis and arteriolar vasodilation

Sheng, JZ, Ella, S, Davis, MJ, Hill, MA, Braun, AP

FASEB J 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
potassium channel activity of Small conductance Ca2+ activated potassium channel [plasma membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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